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Outputs (4)

Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases (2013)
Journal Article
Fuller, H. R., Humphrey, E. L., & Morris, G. E. (2013). Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases. Future Medicinal Chemistry, 5(17), 2091-2101. https://doi.org/10.4155/fmc.13.165

There are several lines of laboratory-based evidence emerging to suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the... Read More about Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases.

The gemin2-binding site on SMN protein: Accessibility to antibody (2013)
Journal Article
Lam, L. T., Fuller, H. R., & Morris, G. E. (2013). The gemin2-binding site on SMN protein: Accessibility to antibody. Biochemical and Biophysical Research Communications, 438(4), 624-627. https://doi.org/10.1016/j.bbrc.2013.08.005

Reduced levels of SMN (survival-of-motor-neurons) protein are the cause of spinal muscular atrophy, an inherited disorder characterised by loss of motor neurons in early childhood. SMN associates with more than eight other proteins to form an RNA-bin... Read More about The gemin2-binding site on SMN protein: Accessibility to antibody.

Valproate reduces collagen and osteonectin in cultured bone cells (2013)
Journal Article
Humphrey, E. L., Morris, G. E., & Fuller, H. R. (2013). Valproate reduces collagen and osteonectin in cultured bone cells. Epilepsy Research, 106(3), 446-450. https://doi.org/10.1016/j.eplepsyres.2013.06.011

Valproate is a histone deacetylase (HDAC) inhibitor that was introduced more than 40 years ago and is commonly used to treat epilepsy and mood disorders. Its long-term side effects can include bone loss, although the exact mechanism for this is curre... Read More about Valproate reduces collagen and osteonectin in cultured bone cells.