Outputs (108)

Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology (2013)
Journal Article
Guan, J., Han, J., Zhang, D., Chu, C., Liu, H., Sun, J., …Zhang, T. (2014). Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology. European Journal of Pharmaceutics and Biopharmaceutics, 86(3), 376-382. https://doi.org/10.1016/j.ejpb.2013.10.008

The aim of this study was to design a silica-supported solid dispersion of a water-insoluble drug, glyburide, to increase its dissolution rate and oral absorption using supercritical fluid (SCF) technology. DSC and PXRD results indicated that the enc... Read More about Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology.

Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls (2013)
Journal Article
(2013). Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls. BMC Public Health, https://doi.org/10.1186/1471-2458-13-1003

Background
Many children do not meet current UK physical activity (PA) guidelines. Girls are less active than boys throughout childhood, and the age-related decline in PA, particularly from early adolescence, is steeper for girls than for boys. Danc... Read More about Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls.

A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation (2013)
Journal Article
McCarthy, H., & Roberts, S. (2013). A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation. Osteoarthritis and Cartilage, 21(12), 2048-2057. https://doi.org/10.1016/j.joca.2013.10.004

Objective
In this study, we compare the clinical and histological outcome between periosteum and Chondrogide® during autologous chondrocyte implantation (ACI).

Method
This study consisted of 88 patients having received ACI in the knee; 33 treate... Read More about A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation.

Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model (2013)
Journal Article
El Haj, A., Kehoe, O., Morris, R., & Markides, H. (2013). Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model. Stem Cell Research and Therapy, 126 -?. https://doi.org/10.1186/scrt337

INTRODUCTION: The application of mesenchymal stem cells (MSCs) in treating rheumatoid arthritis (RA) has been made possible by the immunosuppressive and differentiation abilities of these cells. A non-invasive means of assessing cell integration and... Read More about Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model.

Disadvantaged former miners’ perspectives on smoking cessation: A qualitative study (2013)
Journal Article
White, S., & Baird, W. (2013). Disadvantaged former miners’ perspectives on smoking cessation: A qualitative study. Health Education Journal, 72(6), 755-760. https://doi.org/10.1177/0017896912468817

Objective:
To explore disadvantaged former miners’ perspectives in north Derbyshire, United Kingdom (UK) on smoking and smoking cessation.
Methods:
In-depth, audiotaped interviews with 16 disadvantaged former miners who smoked or had stopped smoki... Read More about Disadvantaged former miners’ perspectives on smoking cessation: A qualitative study.

Abstract A085: miR-222/221 in aggressive breast cancer (2013)
Journal Article
Di Leva, G., Piovan, C., Cheung, D., Briskin, D., Kumar, A., Nuovo, G., …Croce, C. (2013). Abstract A085: miR-222/221 in aggressive breast cancer. Molecular Cancer Research, 11(10_Supplement), A085-A085. https://doi.org/10.1158/1557-3125.advbc-a085

MicroRNAs (miRNAs) are small non coding RNAs that regulate gene expression at post-transcriptional level through translational inhibition and/or degradation of mRNA target genes. Recent evidence points to a widespread role for miRNAs in the initiatio... Read More about Abstract A085: miR-222/221 in aggressive breast cancer.

Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury (2013)
Journal Article
Weightman, A., Jenkins, S., Pickard, M., Chari, D., & Yang, Y. (2014). Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 291-295. https://doi.org/10.1016/j.nano.2013.09.001

Non-neuronal cells of the central nervous system (CNS), termed “neuroglia,” play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a prom... Read More about Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury.

Association of glycation gap with mortality and vascular complications in diabetes (2013)
Journal Article
(2013). Association of glycation gap with mortality and vascular complications in diabetes. Diabetes Care, 3247 -3253. https://doi.org/10.2337/dc12-1040

OBJECTIVE: The "glycation gap" (G-gap), an essentially unproven concept, is an empiric measure of disagreement between HbA1c and fructosamine, the two indirect estimates of glycemic control. Its association with demographic features and key clinical... Read More about Association of glycation gap with mortality and vascular complications in diabetes.

Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets. (2013)
Journal Article
Sage, S., Pugh, N., Farndale, R., & Harper, A. (2013). Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets. https://doi.org/10.1002/phy2.85

We have previously demonstrated that Na(+)/Ca(2+) exchangers (NCXs) potentiate Ca(2+) signaling evoked by thapsigargin in human platelets, via their ability to modulate the secretion of autocoids from dense granules. This link was confirmed in platel... Read More about Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets..

Teaching clinical reasoning to medical students (2013)
Journal Article
(2013). Teaching clinical reasoning to medical students. Clinical Teacher, 308 - 312. https://doi.org/10.1111/tct.12043

BACKGROUND: Keele Medical School's new curriculum includes a 5-week course to extend medical students' consultation skills beyond those historically required for competent inductive diagnosis. CONTEXT: Clinical reasoning is a core skill for the pract... Read More about Teaching clinical reasoning to medical students.