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Outputs (205)

Use of fibrates in the Metabolic Syndrome and Diabetics: practical tips (2018)
Book Chapter
(2018). Use of fibrates in the Metabolic Syndrome and Diabetics: practical tips. In RSSDI Diabetes Update 2018 (356-361). https://doi.org/10.5005/jp/books/18092_73

Cardiovascular disease (CVD), a cause of mortality worldwide, accounted for 28% of United Kingdom deaths in 20121. Risk reduction is based on improving modifiable risk factors with lipid lowering therapy being particularly useful2. Because of the imp... Read More about Use of fibrates in the Metabolic Syndrome and Diabetics: practical tips.

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents (2018)
Journal Article
Mbye, H., Richardson, A., Li, W., Horrocks, P., Johnson-Ajinwo, O., & Ullah, I. (2018). The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2018.02.051

Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the human malarial para... Read More about The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.

Perceptions by Adult Patients With Type 1 and 2 Diabetes of Current and Advanced Technologies of Blood Glucose Monitoring: A Prospective Study (2018)
Journal Article
Al-Tamimi, N., Slater, N., Kayyali, R., & ElShaer, A. (2019). Perceptions by Adult Patients With Type 1 and 2 Diabetes of Current and Advanced Technologies of Blood Glucose Monitoring: A Prospective Study. Canadian Journal of Diabetes, 43(1), 27-33. https://doi.org/10.1016/j.jcjd.2018.02.005

Objective
Intensive self-monitoring of blood glucose levels by patients with diabetes achieves optimal glucose control, hence reducing the likelihood of complications.

Methods
This is a prospective, cross-sectional study targeting adults with di... Read More about Perceptions by Adult Patients With Type 1 and 2 Diabetes of Current and Advanced Technologies of Blood Glucose Monitoring: A Prospective Study.

Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis (2018)
Journal Article
Mamas. (2018). Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis. BMC Medicine, https://doi.org/10.1186/s12916-017-0996-0

Background
Primary care provides the foundation for most modern health-care systems, and in the interests of equity, it should be resourced according to local need. We aimed to describe spatially the burden of chronic conditions and primary medical... Read More about Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis.

Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc? (2018)
Journal Article
Brown, S., Matta, A., Gruber, H., Hanley, E., Erwin, M., Roberts, S., …Melrose, J. (2018). Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?. Stem Cells and Development, 147 -165. https://doi.org/10.1089/scd.2017.0213

The aim of this study was to examine the complexity of the stem cell populations in the intervertebral disc (IVD) and understand their role in disc degeneration, with a view of determining whether the resident stem cells could be developed for therap... Read More about Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?.

The twin peg Oxford knee — Medium term survivorship and surgical principles (2018)
Journal Article
Kuiper. (2018). The twin peg Oxford knee — Medium term survivorship and surgical principles. https://doi.org/10.1016/j.knee.2018.01.001

A multicentre study of single peg Oxford knees reported failure associated with osteoarthritis progression, femoral component loosening, unexplained pain and meniscal bearing dislocation. Suboptimally positioned femoral components and intraoperative... Read More about The twin peg Oxford knee — Medium term survivorship and surgical principles.

Pin-site Care And Innovations In Practice: The Royal Stoke University Hospital Experience. (2018)
Journal Article
Ogrodnik, P., & McBride, A. (2018). Pin-site Care And Innovations In Practice: The Royal Stoke University Hospital Experience. Orthopaedic and Trauma Times, 19 - 27

This paper presents the Royal Stoke University Hospital pin-site care protocol. It has evolved during 25 years of fracture management research at the centre and has been developed in accordance with the RCN Consensus Guidelines on Pin-Site Care. Howe... Read More about Pin-site Care And Innovations In Practice: The Royal Stoke University Hospital Experience..

A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells. (2018)
Journal Article
Al-Mayyahi, R. S., Sterio, L. D., Connolly, J. B., Adams, C., Al-Tumah, W. A., Sen, J., …Chari, D. (2018). A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells. Molecular and Cellular Neuroscience, 86, 30-40. https://doi.org/10.1016/j.mcn.2017.11.006

Corticosteroids (CSs) are widely used clinically, for example in pediatric respiratory distress syndrome, and immunosuppression to prevent rejection of stem cell transplant populations in neural cell therapy. However, such treatment can be associated... Read More about A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells..

Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy (2018)
Journal Article
(2018). Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy. Scientific reports, 8:1898 - 8:1898. https://doi.org/10.1038/s41598-018-20287-3

It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000?CpGs) and gene expression analysis after muscle hypertrophy (loadin... Read More about Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy.