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RACK-1 overexpression protects against goniothalamin-induced cell death (2009)
Journal Article
Inayat-Hussain, S., Wong, L., Chan, K., Rajab, N., Din, L., Harun, R., …Williams, G. (2009). RACK-1 overexpression protects against goniothalamin-induced cell death. Toxicology Letters, 191(2-3), 118-122. https://doi.org/10.1016/j.toxlet.2009.08.012

Goniothalamin, a styryllactone, has been shown to induce cytotoxicity via apoptosis in several tumor cell lines. In this study, we have examined the potential role of several genes, which were stably transfected into T-cell lines and which regulate a... Read More about RACK-1 overexpression protects against goniothalamin-induced cell death.

Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells (2009)
Journal Article
Mourtada-Maarabouni, M., & Williams, G. T. (2009). Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells. Leukemia Research, 33(11), 1539-1551. https://doi.org/10.1016/j.leukres.2009.05.013

The control of T-cell survival is of overwhelming importance for preventing leukemia and lymphoma. The present report demonstrates that the serine/threonine protein phosphatase PP4 regulates the survival of both leukemic T-cells and untransformed hum... Read More about Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.

GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer (2008)
Journal Article
Mourtada-Maarabouni, M., Pickard, M. R., Hedge, V. L., Farzaneh, F., & Williams, G. T. (2009). GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene, 28, 195–208. https://doi.org/10.1038/onc.2008.373

Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional expression cloning, we have identified GAS5 (growth arrest-specific transcript 5) as critic... Read More about GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer.

Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5) (2008)
Journal Article
Mourtada-Maarabouni, M., Hedge, V. L., Kirkham, L., Farzaneh, F., & Williams, G. T. (2008). Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). Journal of Cell Science, 121(7), 939-946. https://doi.org/10.1242/jcs.024646

The control of growth of lymphocyte populations is crucial to the physiological regulation of the immune system, and to the prevention of both leukaemic and autoimmune disease. This control is mediated through modulation of the cell cycle and regulat... Read More about Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).

Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells (2008)
Journal Article
Mourtada-Maarabouni, M., & Williams, G. T. (2008). Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1783(8), 1490-1502. https://doi.org/10.1016/j.bbamcr.2008.03.005

The proteins which regulate apoptosis are of great importance both in normal cell biological processes and in the development of pathology in the diverse diseases which involve apoptosis dysfunction. The activity of many of these proteins is controll... Read More about Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells.

Isolation of genes controlling apoptosis through their effects on cell survival (2006)
Journal Article
Williams, G. T., Hughes, J. P., Stoneman, V., Anderson, C. L., McCarthy, N. J., Mourtada-Maarabouni, M., …Farzaneh, F. (2006). Isolation of genes controlling apoptosis through their effects on cell survival. Gene Therapy and Molecular Biology, 10(28), 255-262

The identification of the most suitable molecular targets for gene and drug therapy is the crucial first step in the development of new disease treatments. The rational identification of such targets depends on a detailed understanding of the patholo... Read More about Isolation of genes controlling apoptosis through their effects on cell survival.

The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update (2006)
Journal Article
Maarabouni, M. M., & Williams, G. T. (2006). The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update. Scientific World Journal, 1705 - 1712. https://doi.org/10.1100/tsw.2006.268

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis... Read More about The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update.

Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes (2006)
Journal Article
Mourtada-Maarabouni, M., Keen, J., Clark, J., Cooper, C. S., & Williams, G. T. (2006). Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. Experimental Cell Research, 312(10), 1745-1752. https://doi.org/10.1016/j.yexcr.2006.02.009

RBM5 (RNA-binding motif protein 5/LUCA-15/H37) is encoded at the lung cancer tumor suppressor locus 3p21.3 and itself has several important characteristics of a tumor suppressor, including both potentiation of apoptosis and inhibition of the cell cyc... Read More about Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes.