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Outputs (91)

Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models (2019)
Thesis
Andoh, N. E. (2019). Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413819

During cerebral malaria (CM), sequestration of Plasmodium falciparum infected red blood cells (PRBC) to the blood-brain barrier (BBB) is associated with BBB disruption and long-term neurological sequelae in CM survivors, possibly linked to the activa... Read More about Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models.

Genetic and ecological processes of speciation in the Anopheles coluzzii and Anopheles gambiae sibling species (2019)
Thesis
Dawam, N. N. (2019). Genetic and ecological processes of speciation in the Anopheles coluzzii and Anopheles gambiae sibling species. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414328

Malaria is a leading cause of death, killing thousands every year. Sub-Saharan Africa has the highest mortality rate, with pregnant women and children under the age of five most affected. The culprits responsible for transmission of the disease are m... Read More about Genetic and ecological processes of speciation in the Anopheles coluzzii and Anopheles gambiae sibling species.

Through fog: An autoethnography of childhood emotional neglect. (2019)
Thesis
Blanchard, A. (2019). Through fog: An autoethnography of childhood emotional neglect. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413773

Childhood emotional neglect is increasingly recognised as significant and widespread, potentially linked to adult depression and anxiety, yet it remains hidden, poorly understood, ill-defined, foggy. Less widely researched than other forms of child m... Read More about Through fog: An autoethnography of childhood emotional neglect..

Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma (2019)
Journal Article
Tonge. (2019). Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma. Scientific reports, 9, Article 8912. https://doi.org/10.1038/s41598-019-45257-1

Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies greatly in terms of cause, development, severity, and response to medication, and thus the condition has been subdivided into a number of asthma phenotypes. There i... Read More about Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma.

Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells (2019)
Journal Article
Trent, S., Hall, J., Connelly, W. M., & Errington, A. C. (2019). Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells. eNeuro, 6(3), ENEURO.0364 - 18.2019. https://doi.org/10.1523/ENEURO.0364-18.2019

Copy number variation (CNV) at chromosomal region 15q11.2 is linked to increased risk of neurodevelopmental disorders including autism and schizophrenia. A significant gene at this locus is cytoplasmic fragile X mental retardation protein (FMRP) inte... Read More about Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells.

Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford. (2019)
Journal Article
(2019). Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph16122129

(1) Introduction:
Human exposure to aluminium is a burgeoning problem. In 1988, the population of the Cornish town of Camelford was exposed to exceedingly high levels of aluminium in their potable water supply. Herein we provide evidence that alumi... Read More about Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford..

Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity (2019)
Journal Article
Clifton, N. E., Trent, S., Thomas, K. L., & Hall, J. (2019). Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity. Molecular Neuropsychiatry, 5(3), 147 - 161. https://doi.org/10.1159/000500267

Alterations in synaptic signaling and plasticity occur during the refinement of neural circuits over the course of development and the adult processes of learning and memory. Synaptic plasticity requires the rearrangement of protein complexes in the... Read More about Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity.

Single arm phase II trial assessing the safety, compliance with and activity of Bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers. (2019)
Journal Article
(2019). Single arm phase II trial assessing the safety, compliance with and activity of Bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers. Contemporary Clinical Trials Communications, 100361 - ?. https://doi.org/10.1016/j.conctc.2019.100361

We previously reported the safety and efficacy of low dose BaP [Bezafibrate (Bez) and Medroxyprogesterone acetate (MPA)] in 20 acute myeloid leukaemia (AML) patients for whom chemotherapy was not an option. This study provided evidence that BaP had a... Read More about Single arm phase II trial assessing the safety, compliance with and activity of Bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers..

A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. (2019)
Journal Article
Mycroft-West, C., Cooper, L., Devlin, A., Procter, P., Guimond, S., Guerrini, M., …Skidmore, M. (2019). A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. Marine Drugs, 17, 293 -293. https://doi.org/10.3390/md17050293

Therapeutic options for Alzheimer's disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the Alzheim... Read More about A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease..