Ashim Gupta
Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence.
Gupta, Ashim; Migliorini, Filippo; Bardazzi, Tommaso; Maffulli, Nicola
Authors
Filippo Migliorini
Tommaso Bardazzi
Nicola Maffulli
Abstract
Elbow ailments are common, but conventional treatment modalities have shortcomings, offering only interim pain relief rather than targeting the underlying pathophysiology. The last two decades have seen a marked increase in the use of autologous peripheral blood-derived orthobiologics (APBOs), such as platelet-rich plasma (PRP), to manage elbow disorders. Platelet-rich plasma (PRP) is the most widely used APBO, but its efficacy remains debatable. Consequently, other APBOs, such as platelet lysate (PL), autologous conditioned serum (ACS), gold-induced cytokine (GOLDIC), plasma rich in growth factors (PRGF), autologous protein solution (APS), and hyperacute serum (HS), have been considered. Only a few reviews summarize the results of clinical studies investigating the efficacy of these APBOs in elbow disorders. This review documents the results of clinical studies involving APBOs in managing elbow disorders and summarizes the ongoing clinical studies on different clinical trial protocol repositories comprising these APBOs to manage elbow disorders. This systematic review adhered to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines. In December 2024, PubMed, Embase, and Web of Science were accessed with no additional filters or time constraints. All available clinical studies published in English, French, Spanish, German, or Italian concerning the management of elbow disorders by means of APBOs were considered. Only three clinical studies met our predefined search and inclusion criteria. In particular, two and one studies involving the use of PL and ACS, respectively, were included in this review. Data from 99 patients were obtained. Of them, 57.6% (57 of 99 patients) were women. The mean length of follow-up was 11.9 ± 0.6 months, and the mean age was 42.0 ± 3.5 years. No complications were reported in any of the studies included. The included studies have low to medium risk of bias, and a very low score on methodological quality. Finally, no clinical studies involving the use of GOLDIC, PRGF, APS or HS were identified, and only one ongoing clinical study involving the use of PL was registered. The current peer-reviewed published studies demonstrated that administering APBOs, including PL and ACS, might be safe and effective in reducing pain and improving function in patients with elbow disorders. Further, high-quality studies are required. [Abstract copyright: © 2025. The Author(s).]
Citation
Gupta, A., Migliorini, F., Bardazzi, T., & Maffulli, N. (2025). Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence. Pain and Therapy, https://doi.org/10.1007/s40122-025-00707-9
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 16, 2025 |
Online Publication Date | Jan 29, 2025 |
Publication Date | Jan 29, 2025 |
Deposit Date | Feb 17, 2025 |
Publicly Available Date | Feb 17, 2025 |
Journal | Pain and therapy |
Print ISSN | 2193-8237 |
Electronic ISSN | 2193-651X |
Publisher | Springer |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1007/s40122-025-00707-9 |
Keywords | Hyperacute serum, Regenerative medicine, Plasma rich in growth factors, Orthobiologics, Autologous protein solution, Autologous conditioned serum, Platelet lysate, Gold-induced cytokine, Elbow, Autologous peripheral blood-derived orthobiologics |
Public URL | https://keele-repository.worktribe.com/output/1076310 |
Publisher URL | https://link.springer.com/article/10.1007/s40122-025-00707-9 |
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Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence
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Copyright Statement
The version of record of this article, first published in Pain and Therapy, is available online at Springer Nature's website: https://doi.org/10.1007/s40122-025-00707-9
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