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Interaction between Mean Arterial Pressure and HbA1c in Prediction of Cardiovascular Disease Hospitalisation: A Population-Based Case-Control Study

Yu

Interaction between Mean Arterial Pressure and HbA1c in Prediction of Cardiovascular Disease Hospitalisation: A Population-Based Case-Control Study Thumbnail


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Abstract

Objective. To explore the relationship between mean arterial pressure (MAP), HbA1c, and cardiovascular (CV) hospitalisation risk in type 2 diabetes.

Design. Population-based case-control study.

Settings. Primary and secondary care level in Cambridgeshire, United Kingdom. Participants. 588 patients with type 2 diabetes from 18 English general practices recording a CV hospitalisation in 2009–2011 were included. Risk-set sampling was used to select 2920 gender, age, and practice matched control type 2 diabetes patients.

Main Outcome Measure. Conditional logistic regression was used to explore further dose-response relationships between MAP, HbA1c, and CV hospitalisation risk.

Results. The relationship between MAP and CV hospitalisation was nonlinear ( for linearity test). The MAP associated with the lowest CV hospitalisation risk was 97 (95% CI: 93–101)?mmHg. An interaction between MAP and HbA1c for increased risk of cardiovascular hospitalisation was observed among those with HbA1c < 7% (53?mmol/mol) and MAP < 97?mmHg.

Conclusions. In type 2 diabetes, MAP is a good predictor of CV hospitalisation risk. CV hospitalisation is lowest with a MAP between 93 and 101?mmHg. CV hospitalisation was particularly high among those with both a low MAP and a lower HbA1c.

Acceptance Date May 22, 2016
Publication Date Jun 13, 2016
Journal Journal of Diabetes Research
Print ISSN 2314-6745
Publisher Hindawi
Pages 1-7
DOI https://doi.org/10.1155/2016/8714745
Publisher URL http://www.hindawi.com/journals/jdr/2016/8714745/

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