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Ageing in the musculoskeletal system

Roberts, Sally; Colombier, Pauline; Sowman, Aneka; Mennan, Claire; Rölfing, Jan H D; Guicheux, Jérôme; Edwards, James R

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Sally Roberts

Pauline Colombier

Aneka Sowman

Jan H D Rölfing

Jérôme Guicheux

James R Edwards


The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.


Roberts, S., Colombier, P., Sowman, A., Mennan, C., Rölfing, J. H. D., Guicheux, J., & Edwards, J. R. (2016). Ageing in the musculoskeletal system. Acta orthopaedica, 87(S363), 15- 25.

Journal Article Type Article
Acceptance Date Jun 14, 2016
Online Publication Date Dec 16, 2016
Publication Date Oct 17, 2016
Journal Acta Orthopaedica
Print ISSN 1745-3674
Publisher Informa Healthcare
Peer Reviewed Peer Reviewed
Volume 87
Issue S363
Pages 15- 25
Publisher URL


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