Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study

Dou, Yanna; Sun, Xiran; Liu, Dong; Zhang, Li; Xiao, Jing; Cheng, Genyang; Yu, Dahai; Zhao, Zhanzheng

Abstract

Background
Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR) and estimated GFR (eGFR). One of the mGFR was 99mTc-DTPA scintigraphy method and eGFR using GFR equations were used clinically. Equations were modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Chinese adapted MDRD (C-MDRD). This study assessed the accuracy of three different equations for estimated glomerular filtration rate (eGFR) with mGFR using DTPA scintigraphy method as the standard in a population of Chinese chronic kidney disease patients at the G3a stage.

Results
One hundred and twenty-two patients (age 52.0 ± 15.6 years, 69 were male) were determined as CKD stage 3 based on mGFR. Patients were divided into G3a (47 patients) and G3b (75 patients) subgroups. Bias between eGFR for CKD-EPI and reference mGFR was 0.92 mL/min and 95% limits of agreement was -38.82 to 40.67 mL/min. Bias between eGFR for C-MDRD and mGFR was 3.76 and 95% limits of agreement was -39.32 to 46.85 mL/min. Bias between eGFR for MDRD and mGFR was 3.53 and 95% limits of agreement was -43.35 to 50.4 mL/min. The CKD-EPI equation showed better diagnostic value with a greater area under the receiver operating characteristic curve (AUC: 0.763). AUC for MDRD and C-MDRD were 0.75 and 0.757, respectively.

Conclusions
There were no obvious advantages in accuracy, sensitivity, and specificity for the diagnosis of patients at the G3a stage using the CKD-EPI equation.

• Journal Article Type: Article
• Acceptance Date: Jan 24, 2017
• Publication Date: Feb 24, 2017
• Journal: BMC Research Notes
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Article Number: 107
• DOI: https://doi.org/10.1186/s13104-017-2400-8
• Keywords: G3a stage, Glomerular filtration rate equations, Accuracy, Chronic kidney disease, Biochemistry, Genetics, Molecular Biology, Medicine
• Publisher URL: https://doi.org/10.1186/s13104-017-2400-8
• PMID: 28235417