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Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis.

Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis. Thumbnail


Abstract

BACKGROUND: Chronic infection with Burkholderia cepacia complex (BCC) has a detrimental effect on morbidity and mortality for patients with cystic fibrosis (CF). It is therefore logical to attempt to eradicate new isolates however there is a paucity of information to guide treatment. We report the successful eradication of new isolates of BCC in two children with CF. CASE PRESENTATION: Burkholderia cepacia was successfully eradicated in a 14 year old boy with CF and Burkholderia gladioli was successfully eradicated in a six year old girl with CF. In both children two weeks of intravenous (IV) tobramycin, ceftazidime and temocillin were used followed by three months of inhaled tobramycin. Bronchoalveolar lavage samples taken during flexible bronchoscopy were used prior to treatment to exclude spontaneous clearance as well as after treatment to confirm eradication. CONCLUSIONS: New isolates of BCC can be successfully eradicated in children with CF. More research is urgently required in this area to identify the best treatment regimen for BCC eradication.

Citation

(2016). Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis. BMC Pharmacology and Toxicology, 14 - ?. https://doi.org/10.1186/s40360-016-0054-0

Acceptance Date Feb 14, 2016
Publication Date Mar 28, 2016
Journal BMC Pharmacology and Toxicology
Publisher Springer Verlag
Pages 14 - ?
DOI https://doi.org/10.1186/s40360-016-0054-0
Keywords Burkholderia cepacia complex; Cystic fibrosis; Eradication; Paediatrics
Publisher URL https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-016-0054-0

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