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G-quadruplexes: prediction, characterization, and biological application

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Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure and function. Accumulating knowledge about the structural properties of G-quadruplexes has helped to design and develop a repertoire of molecular and chemical tools for biological applications. This review highlights how these exciting methods and findings have opened new doors to investigate the potential functions and applications of G-quadruplexes in basic and applied biosciences.

Acceptance Date Jun 16, 2017
Publication Date Jul 26, 2017
Journal Trends in Biotechnology
Print ISSN 0167-7799
Publisher Elsevier
Pages 997-1013
Keywords Nucleic acid structure; G-quadruplex; cell imaging; next-generation sequencing; aptamer; biosensing
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