X-ray diffraction from bone employing annular and semi-annular beams

Dicken, AJ; Evans, JPO; Rogers, KD; Stone, N; Greenwood, CE; Godber, SX; Prokopiou, D; Clement, JG; Lyburn, ID; Martin, RM; Zioupos, P

Abstract

There is a compelling need for accurate, low cost diagnostics to identify osteotissues that are associated with a high risk of fracture within an individual. To satisfy this requirement the quantification of bone characteristics such as ‘bone quality’ need to exceed that provided currently by densitometry. Bone mineral chemistry and microstructure can be determined from coherent x-ray scatter signatures of bone specimens. Therefore, if these signatures can be measured, in vivo, to an appropriate accuracy it should be possible by extending terms within a fracture risk model to improve fracture risk prediction.
In this preliminary study we present an examination of a new x-ray diffraction technique that employs hollow annular and semi-annular beams to measure aspects of ‘bone quality’. We present diffractograms obtained with our approach from ex vivo bone specimens at Mo Ka and W Ka energies.
Primary data is parameterized to provide estimates of bone characteristics and to indicate the precision with which these can be determined.

Citation

Dicken, A., Evans, J., Rogers, K., Stone, N., Greenwood, C., Godber, S., …Zioupos, P. (2015). X-ray diffraction from bone employing annular and semi-annular beams. Physics in Medicine and Biology, 60(15), 5803 - 5812. https://doi.org/10.1088/0031-9155/60/15/5803

• Journal Article Type: Article
• Acceptance Date: Jun 8, 2015
• Publication Date: Jul 10, 2015
• Journal: Physics in Medicine and Biology
• Print ISSN: 0031-9155
• Publisher: IOP Publishing
• Peer Reviewed: Peer Reviewed
• Volume: 60
• Issue: 15
• Pages: 5803 - 5812
• DOI: https://doi.org/10.1088/0031-9155/60/15/5803
• Keywords: x-ray diffraction, diagnostics, osteoporosis, annular beam
• Publisher URL: https://iopscience.iop.org/article/10.1088/0031-9155/60/15/5803