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Triglyceride Glucose Index Predicting Cardiovascular Mortality in Chinese Initiating Peritoneal Dialysis: A Cohort Study




Insulin resistance (IR) is increased among people with end-stage renal disease (ESRD). The Triglyceride glucose (TyG) index is a marker of IR and is also associated with the prognosis of cardiovascular disease among patients initiating peritoneal dialysis (PD). This study was aimed at examining the associations between TyG index and cardiovascular deaths in patients initiating PD.

Three thousand fifty-four patients initiating PD between 2007 and 2014 were included in a prospective cohort derived from Henan PD Registry, TyG index alongside other baseline characteristics were measured when ESRD patients initiated PD. Logistic regression adjusting for age, gender, and major cardiovascular risk factors estimated the association between TyG index and subsequent cardiovascular mortality within 2 years since the initiation of PD.

TyG index was positively associated with cardiovascular mortality: adjusted incidence rates ratio (95% CI) comparing the highest vs. lowest TyG index quartile was 2.32 (2.12–2.55) in all, 2.22 (2.01–2.46) in those with body mass index (BMI) <25 kg/m2, and 2.82 (2.24–3.54) in those with BMI =25 kg/m2, respectively. Linear dose-response relationships were revealed in all and by BMI.

TyG index might be a prognostic factor in predicting cardiovascular mortality among patients initiating PD.

Acceptance Date Apr 22, 2019
Publication Date Jul 17, 2019
Journal Kidney and Blood Pressure Research
Print ISSN 1420-4096
Publisher Karger Publishers
Pages 669-678
Keywords Triglyceride glucose index, Cardiovascular diseases, Mortality, Peritoneal dialysis, Prognostic factor
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