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Genetic overlap between type 2 diabetes and depression in a Sri Lankan population twin sample.

Genetic overlap between type 2 diabetes and depression in a Sri Lankan population twin sample. Thumbnail


Abstract

OBJECTIVES: Results from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-western populations. We aimed to examine whether there are common genetic factors between type 2 diabetes and depression in a Sri-Lankan population, using genetic model-fitting analysis. METHOD: The Colombo Twin and Singleton Study-Phase 2 consists of 2019 singletons, 842 monozygotic and 578 dizygotic twin-pairs. The primary outcomes were self-reported type 2 diabetes diagnosis and Beck Depression Inventory scores. Standard bivariate twin models were fitted to estimate the genetic and environmental (co)variance of type 2 diabetes and depression. RESULTS: In the best-fitting model, the phenotypic correlation between type 2 diabetes and depression was significant in females only (r=0.15 (0.08-0.21)). This association was primarily attributed to a significant genetic correlation between the traits (rA=0.53 (0.19-0.98)). CONCLUSIONS: In females, but not males, we found a significant genetic overlap between type 2 diabetes and depression in the context of a modest phenotypic correlation.

Citation

(2019). Genetic overlap between type 2 diabetes and depression in a Sri Lankan population twin sample. Psychosomatic Medicine, 247-253. https://doi.org/10.1097/PSY.0000000000000771

Acceptance Date Nov 27, 2019
Publication Date Feb 7, 2019
Journal Psychosomatic Medicine
Print ISSN 0033-3174
Publisher Lippincott, Williams & Wilkins
Pages 247-253
DOI https://doi.org/10.1097/PSY.0000000000000771
Keywords type 2 diabetes, depression, genetic, twin, structural equation modeling
Publisher URL https://journals.lww.com/psychosomaticmedicine/Abstract/publishahead/Genetic_overlap_between_type_2_diabetes_and.98579.aspx#pdf-link

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