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Gene drives to fight malaria: current state and future directions

Hammond, Andrew M.; Galizi, Roberto

Gene drives to fight malaria: current state and future directions Thumbnail


Andrew M. Hammond


Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining, these tools may be used to generate cost-effective interventions that benefit society without obvious bias related to wealth, age or education. Their species-specific design offers the potential to reduce environmental risks and aim to be compatible and complementary with other control strategies, potentially expediting the elimination and eradication of malaria. A number of strategies have been proposed for gene-drive based control of the malaria mosquito and recent demonstrations have shown proof-of-principle in the laboratory. Though several technical, ethical and regulatory challenges remain, none appear insurmountable if research continues in a step-wise and open manner.

Journal Article Type Article
Acceptance Date Feb 9, 2018
Publication Date Feb 19, 2018
Publicly Available Date May 26, 2023
Journal Pathogens and Global Health
Print ISSN 2047-7724
Publisher Taylor and Francis
Pages 412 - 423
Keywords Gene, Malaria, Directions
Publisher URL


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