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Derivation and validation of a risk score predicting early-onset risk of peritonitis among patients initialising peritoneal dialysis: a cohort study

Ma, S; Cai, Y; Wang, Z; Zhao, Z; Xiao, J; Yu, D

Derivation and validation of a risk score predicting early-onset risk of peritonitis among patients initialising peritoneal dialysis: a cohort study Thumbnail


Authors

S Ma

Y Cai

Z Wang

Z Zhao

J Xiao



Abstract

Objectives
Early onset peritonitis (EOP) increases risk of clinical complications in patients initialising peritoneal dialysis (PD). This study aimed to develop and validate a risk prediction model for EOP among patients initialising PD.

Methods
3,772 patients registered with the Henan Peritoneal Dialysis Registry (HPDR) between 2007-2015 were included. The main outcome, EOP was defined as the incident peritonitis occurred within 6 months since the initialisation of PD. Multivariable logistic regression modelling was applied to derive the risk score. All accessible clinical measurements were screened as potential predictors. Assessment of the developed model regarding model discrimination and calibration was performed by C statistics and calibration slope, respectively, and validated internally through bootstrapping (1000-fold)
method to adjust for over-fitting.

Results
The absolute risk of EOP was 14.5%. Age, cardiac function measurements, serum electrolyte test items, lipid profiles, liver function test items, blood urea nitrogen, and white cell count were significant predictors of EOP in the final risk score. Good model discrimination with C statistics above 0.70 and calibration of agreed observed and predicted risks were identified in the model.

Conclusion
The prediction model that quantify risks of EOP has been developed and validated. It is based on a small number of clinical metabolic measurements that are available for patients initialising PD in many developing countries and could serve as the tools to screen the population at high risk of EOP.

Journal Article Type Article
Acceptance Date Aug 4, 2020
Online Publication Date Aug 8, 2020
Publication Date 2020-10
Journal International Journal of Infectious Diseases
Print ISSN 1201-9712
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 99
Pages 301-306
DOI https://doi.org/10.1016/j.ijid.2020.08.009
Keywords Early-onset peritonitis, Peritoneal dialysis, Prognostic model, Cohort
Publisher URL https://doi.org/10.1016/j.ijid.2020.08.009

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