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The osmo-metabolic approach: a novel and tantalizing glucose-sparing strategy in peritoneal dialysis.

Bonomini, Mario; Zammit, Victor; Divino-Filho, José C.; Davies, Simon J.; Di Liberato, Lorenzo; Arduini, Arduino; Lambie, Mark

The osmo-metabolic approach: a novel and tantalizing glucose-sparing strategy in peritoneal dialysis. Thumbnail


Authors

Mario Bonomini

Victor Zammit

José C. Divino-Filho

Lorenzo Di Liberato

Arduino Arduini



Abstract

Peritoneal dialysis (PD) is a viable but under-prescribed treatment for uremic patients. Concerns about its use include the bio-incompatibility of PD fluids, due to their potential for altering the functional and anatomical integrity of the peritoneal membrane. Many of these effects are thought to be due to the high glucose content of these solutions, with attendant issues of products generated during heat treatment of glucose-containing solutions. Moreover, excessive intraperitoneal absorption of glucose from the dialysate has many potential systemic metabolic effects. This article reviews the efforts to develop alternative PD solutions that obviate some of these side effects, through the replacement of part of their glucose content with other osmolytes which are at least as efficient in removing fluids as glucose, but less impactful on patient metabolism. In particular, we will summarize clinical studies on the use of alternative osmotic ingredients that are commercially available (icodextrin and amino acids) and preclinical studies on alternative solutions under development (taurine, polyglycerol, carnitine and xylitol). In addition to the expected benefit of a glucose-sparing approach, we describe an 'osmo-metabolic' approach in formulating novel PD solutions, in which there is the possibility of exploiting the pharmaco-metabolic properties of some of the osmolytes to attenuate the systemic side effects due to glucose. This approach has the potential to ameliorate pre-existing co-morbidities, including insulin resistance and type-2 diabetes, which have a high prevalence in the dialysis population, including in PD patients.

Citation

Bonomini, M., Zammit, V., Divino-Filho, J. C., Davies, S. J., Di Liberato, L., Arduini, A., & Lambie, M. (2020). The osmo-metabolic approach: a novel and tantalizing glucose-sparing strategy in peritoneal dialysis. Journal of Nephrology, 34, Article 503–519. https://doi.org/10.1007/s40620-020-00804-2

Journal Article Type Article
Acceptance Date Jul 9, 2020
Publication Date Aug 7, 2020
Journal Journal of Nephrology
Print ISSN 1121-8428
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 34
Article Number 503–519
DOI https://doi.org/10.1007/s40620-020-00804-2
Keywords Peritoneal dialysis, Glucose-sparing, Solution, Carnitine, Xylitol
Publisher URL https://doi.org/10.1007/s40620-020-00804-2

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