Courtney J. Mycroft-West
Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1
Mycroft-West, Courtney J.; Devlin, Anthony J.; Cooper, Lynsay C.; Guimond, Scott E.; Procter, Patricia; Guerrini, Marco; Miller, Gavin J.; Fernig, David G.; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.
Authors
Anthony J. Devlin
Lynsay C. Cooper
Scott Guimond s.e.guimond@keele.ac.uk
Patricia Procter p.procter@keele.ac.uk
Marco Guerrini
Gavin Miller g.j.miller@keele.ac.uk
David G. Fernig
Edwin A. Yates
Marcelo Andrade De Lima m.andrade.de.lima@keele.ac.uk
Mark Skidmore m.a.skidmore@keele.ac.uk
Abstract
Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years. The widely used clinical anticoagulant heparin has been reported to exert beneficial effects through multiple pathophysiological pathways involved in the aetiology of Alzheimer’s Disease, for example, amyloid peptide production and clearance, tau phosphorylation, inflammation and oxidative stress. Despite the therapeutic potential of heparin as a multi-target drug for Alzheimer’s disease, the repurposing of pharmaceutical heparin is proscribed owing to the potent anticoagulant activity of this drug. Here, a heterogenous non-anticoagulant glycosaminoglycan extract, obtained from the shrimp Litopenaeus vannamei, was found to inhibit the key neuronal ß-secretase, BACE1, displaying a more favorable therapeutic ratio compared to pharmaceutical heparin when anticoagulant activity is considered.
Citation
Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Guimond, S. E., Procter, P., Guerrini, M., …Skidmore, M. A. (2021). Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1. Marine Drugs, 19(4), 203 -203. https://doi.org/10.3390/md19040203
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 26, 2021 |
Online Publication Date | Apr 3, 2021 |
Publication Date | Apr 3, 2021 |
Journal | Marine Drugs |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 19 |
Issue | 4 |
Pages | 203 -203 |
DOI | https://doi.org/10.3390/md19040203 |
Keywords | Alzheimer’s disease, amyloid-ß, BACE1, ß-secretase, glycosaminoglycan, chondroitin sulfate, heparin, heparan sulphate, Litopenaeus vannamei |
Public URL | https://keele-repository.worktribe.com/output/419710 |
Publisher URL | https://doi.org/10.3390/md19040203 |
Files
marinedrugs-19-00203.pdf
(4.5 Mb)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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