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Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases

Paraskevaidi, M; Baker, MJ; Butler, HJ; Byrne, HJ; Chakkumpulakkal, TPV; Loren, C; St John, C; Gardner, P; Gassner, C; Kazarian, SG; Kochan, K; Kyrgiou, M; Lima, KMG; Martin-Hirsch, PL; Paraskevaidis, E; Pebotuwa, S; Adegoke, JA; Sala, A; Santos, M; Sule-Suso, J; Tyagi, G; Walsh, M; Wood, B

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Authors

M Paraskevaidi

MJ Baker

HJ Butler

HJ Byrne

TPV Chakkumpulakkal

C Loren

C St John

P Gardner

C Gassner

SG Kazarian

K Kochan

M Kyrgiou

KMG Lima

PL Martin-Hirsch

E Paraskevaidis

S Pebotuwa

JA Adegoke

A Sala

M Santos

G Tyagi

M Walsh

B Wood



Abstract

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the need for multiple tests before a definitive diagnosis. Spectroscopic techniques, including infrared (IR) and Raman, have attracted great interest in the medical field, with applications expanding from early disease detection to monitoring and real-time diagnosis. This review highlights applications of IR and Raman spectroscopy, with a focus on cancer and infectious diseases since 2015, and underscores the diverse sample types that can be analyzed, such as biofluids, cells and tissues. Studies involving more than 25 participants per group (disease and control group; if no control group >25 in disease group) were considered eligible, to retain the clinical focus of the paper. Following literature searches, we identified 94 spectroscopic studies on different cancers and 30 studies on infectious diseases. The review suggests that such technologies have the potential to develop into an objective, inexpensive, point-of-care test or facilitate disease diagnosis and monitoring. Up-to-date considerations for the implementation of spectroscopic techniques into a clinical setting, health economics and successful applications of vibrational spectroscopic tests in the clinical arena are also discussed.

Citation

Paraskevaidi, M., Baker, M., Butler, H., Byrne, H., Chakkumpulakkal, T., Loren, C., …Wood, B. (2021). Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases. Applied Spectroscopy Reviews, https://doi.org/10.1080/05704928.2021.1946076

Acceptance Date Oct 6, 2021
Publication Date Oct 6, 2021
Journal Applied Spectroscopy Reviews
Print ISSN 0570-4928
Publisher Taylor and Francis
DOI https://doi.org/10.1080/05704928.2021.1946076
Publisher URL https://doi.org/10.1080/05704928.2021.1946076

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