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1150-P: Ethnic Differences in 25-Year Risk of Incident Chronic Kidney Disease among People with Type 2 Diabetes in New Zealand

PICKERING, KA; Yu, D; OSUAGWU, UL; BAKER, J; CUTFIELD, RG; ORR-WALKER, BJ; ZHAO, Z; JAYANATHA, K; SIMMONS, D

Authors

KA PICKERING

UL OSUAGWU

J BAKER

RG CUTFIELD

BJ ORR-WALKER

Z ZHAO

K JAYANATHA

D SIMMONS



Abstract

<jats:p>Background: Ethnic differences exist in the risk of end stage kidney disease in type 2 diabetes (T2DM) . We compared the risk of developing CKD stages II-V between Maori, Pasifika, and NZ Europeans (NZE) with T2DM in NZ over a 25-year period.</jats:p> <jats:p>Methods: We linked a large primary care audit program to national registration databases. Those with CKD II-V were excluded. A tapered matching method was used to balance potential confounders. Comparative cohorts were formed separately between NZE and Maori, and between NZE and Pasifika. Cox regression tested for ethnic group differences in future risk of any and each CKD stage between 1994 and 2018.</jats:p> <jats:p>Results: Compared with NZE (n=2028) , the hazard ratios (HR) for developing any CKD, CKD stages II thru V for Maori (n=2215) were 1.18 (95% CI: 0.99-1.41) , 1. (0.91-1.32) , 1.70 (1.19-2.43) , 3.93 (2.16-7.14) and 3.74 (1.74-8.05) respectively. The HR for Pasifika (n=3101) compared with NZE (n=2474) for developing any CKD, CKD stages II thru V were 1.31 (1.09-1.57) , 1.26 (1.05-1.52) , 1.71 (1.14-2.57) , 3.75 (1.40-10.05) and 4.96 (1.56-15.75) respectively. Figures A-D show the risks of CKD II and CKD IV/V among NZE (blue) and Maori/Pasifika over time.</jats:p> <jats:p>Conclusion: Significant ethnic differences exist in the risk of progressing to each stage of CKD (especially stage V) among people with T2DM in NZ. Research into the mechanisms underlying these differences are warranted.</jats:p> <jats:p /> <jats:sec> <jats:title>Disclosure</jats:title> <jats:p>D.Yu: None. U.L.Osuagwu: None. J.Baker: n/a. R.G.Cutfield: None. B.J.Orr-walker: None. Z.Zhao: None. K.A.Pickering: None. K.Jayanatha: None. D.Simmons: Other Relationship; Elsevier, Research Support; Abbott, Hitachi, Ltd., Novo Nordisk, Speaker's Bureau; Sanofi.</jats:p> </jats:sec>

Citation

PICKERING, K., Yu, D., OSUAGWU, U., BAKER, J., CUTFIELD, R., ORR-WALKER, B., …SIMMONS, D. 1150-P: Ethnic Differences in 25-Year Risk of Incident Chronic Kidney Disease among People with Type 2 Diabetes in New Zealand. Presented at 82nd Scientific sessions

Presentation Conference Type Speech
Conference Name 82nd Scientific sessions
Publicly Available Date May 30, 2023
Publisher American Diabetes Association
DOI https://doi.org/10.2337/db22-1150-p
Publisher URL https://diabetesjournals.org/diabetes/article/71/Supplement_1/1150-P/146113/1150-P-Ethnic-Differences-in-25-Year-Risk-of