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Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017

Mamas

Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017 Thumbnail


Authors



Abstract

Background and aims
There is limited data on temporal trends of cardiovascular hospitalizations and outcomes amongst cancer patients. We describe the distribution, trends of admissions, and in-hospital mortality associated with key cardiovascular diseases among cancer patients in the USA between 2004 and 2017.

Methods
Using the Nationwide Inpatient Sample we, identified admissions with five cardiovascular diseases of interest: acute myocardial infarction (AMI), pulmonary embolism (PE), ischaemic stroke, heart failure, atrial fibrillation (AF) or atrial flutter, and intracranial haemorrhage. Patients were stratified by cancer status and type. We estimated crude annual rates of hospitalizations and annual in-hospital all-cause mortality rates.

Results
From >42.5 million hospitalizations with a primary cardiovascular diagnosis, 1.9 million (4.5%) had a concurrent record of cancer. Between 2004 and 2017, cardiovascular admission rates increased by 23.2% in patients with cancer, whilst decreasing by 10.9% in patients without cancer. The admission rate increased among cancer patients across all admission causes and cancer types except prostate cancer. Patients with haematological (9.7–13.5), lung (7.4–8.9), and GI cancer (4.6–6.3) had the highest crude rates of cardiovascular hospitalizations per 100?000 US population. Heart failure was the most common reason for cardiovascular admission in patients across all cancer types, except GI cancer (crude admission rates of 13.6–16.6 per 100?000 US population for patients with cancer).

Conclusions
In contrast to declining trends in patients without cancer, primary cardiovascular admissions in patients with cancer is increasing. The highest admission rates are in patients with haematological cancer, and the most common cause of admission is heart failure.

Citation

Mamas. (2022). Impact of cancer diagnosis on distribution and trends of cardiovascular hospitalizations in the USA between 2004 to 2017. European Heart Journal, 787-797. https://doi.org/10.1093/ehjqcco/qcac045

Acceptance Date Jul 27, 2022
Online Publication Date Aug 1, 2022
Publication Date Nov 1, 2022
Publicly Available Date Aug 2, 2023
Journal European Heart Journal
Print ISSN 0195-668X
Publisher Oxford University Press
Pages 787-797
DOI https://doi.org/10.1093/ehjqcco/qcac045
Publisher URL https://academic.oup.com/ehjqcco/article-abstract/8/7/787/6652898?redirectedFrom=fulltext