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Zoonotic Tuberculosis – The Changing Landscape

Kock, R; Michel, AL; Yeboah-Manu, D; Azhar, EI; Torrelles, JB; Cadmus, SI; Brunton, L; Chakaya, JM; Marais, B; Mboera, L; Rahim, Z; Haider, N; Zumla, A

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R Kock

AL Michel

D Yeboah-Manu

EI Azhar

JB Torrelles

SI Cadmus

L Brunton

JM Chakaya

B Marais

L Mboera

Z Rahim

A Zumla


Despite slow reductions in the annual burden of active human tuberculosis (TB) cases, zoonotic TB (zTB) remains a poorly monitored and an important unaddressed global problem. There is a higher incidence in some regions and countries, especially where close association exists between growing numbers of cattle (the major source of Mycobacterium bovis) and people, many suffering from poverty, and where dairy products are consumed unpasteurised. More attention needs to be focused on possible increased zTB incidence resulting from growth in dairy production globally and increased demand in low income countries in particular. Evidence of new zoonotic mycobacterial strains in South Asia and Africa (e.g. M. orygis), warrants urgent assessment of prevalence, potential drivers and risk in order to develop appropriate interventions. Control of M. bovis infection in cattle through detect and cull policies remain the mainstay of reducing zTB risk, whilst in certain circumstances animal vaccination is proving beneficial. New point of care diagnostics will help to detect animal infections and human cases. Given the high burden of human tuberculosis (caused by M. tuberculosis) in endemic areas, animals are affected by reverse zoonosis, including multi-drug resistant strains. This, may create drug resistant reservoirs of infection in animals. Like COVID-19, zTB is evolving in an ever-changing global landscape.


Kock, R., Michel, A., Yeboah-Manu, D., Azhar, E., Torrelles, J., Cadmus, S., …Zumla, A. (2021). Zoonotic Tuberculosis – The Changing Landscape. International Journal of Infectious Diseases, 113(S1), S68 - S72.

Journal Article Type Article
Acceptance Date Feb 23, 2021
Online Publication Date Mar 10, 2021
Publication Date 2021-12
Publicly Available Date May 30, 2023
Journal International Journal of Infectious Diseases
Print ISSN 1201-9712
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 113
Issue S1
Pages S68 - S72
Publisher URL
PMID 33713812


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