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Disparities in the age at osteoarthritis diagnosis: an indicator for equity-focused prevention

Peat, George; Kiadaliri, Ali; Yu, Dahai

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Authors

George Peat

Ali Kiadaliri



Abstract

Objectives: To investigate the association between vaccination against COVID-19 and inflammatory bowel disease (IBD) flare.
Methods: Patients with IBD vaccinated against COVID-19 who consulted for disease flare between 01/12/2020 and 31/12/2021 were ascertained from the Clinical Practice Research Datalink (CPRD). IBD flares were identified using consultation and corticosteroid prescription records. Vaccinations were identified using product codes and vaccination dates. The study period was partitioned into vaccine-exposed (vaccination date and 21-days immediately after), pre-vaccination (7-days immediately before vaccination), and the remaining vaccine-unexposed periods. Participants contributed data with multiple vaccinations and IBD flares. Season adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI) were calculated using self-controlled case-series analysis.
Results: Data for 1911 IBD cases, 52% female, mean age 49 years, and 63% with ulcerative colitis (UC) were included. COVID-19 vaccination was not associated with increased IBD flares in the vaccine-exposed period when all vaccinations were considered (aIRR (95%CI) 0.89 (0.77-1.02), 0.79 (0.66-0.95), and 1.00 (0.79–1.27) in IBD overall, UC, and Crohn’s disease respectively). Analyses stratified to include only first, second or third COVID-19 vaccinations found no significant association between vaccination and IBD flares in the vaccine exposed period (aIRR (95%CI) 0.87 (0.71-1.06), 0.93 (0.75-1.15) and 0.86 (0.63-1.17) respectively). Similarly, stratification by COVID-19 before vaccination, and by vaccination with vectored DNA or mRNA vaccine did not reveal an increased risk of flare in any of these subgroups.
Conclusion: Vaccination against COVID-19 was not associated with IBD flares regardless of prior COVID-19 infection and whether mRNA or DNA vaccines were used.

Citation

Peat, G., Kiadaliri, A., & Yu, D. (2023). Disparities in the age at osteoarthritis diagnosis: an indicator for equity-focused prevention. Rheumatology, 62(8), e240-e241. https://doi.org/10.1093/rheumatology/kead080

Journal Article Type Letter
Acceptance Date Feb 10, 2023
Online Publication Date Feb 20, 2023
Publication Date Aug 1, 2023
Publicly Available Date Feb 21, 2024
Journal Rheumatology
Print ISSN 1462-0324
Publisher Oxford University Press
Volume 62
Issue 8
Pages e240-e241
DOI https://doi.org/10.1093/rheumatology/kead080
Keywords Pharmacology (medical), Rheumatology
Publisher URL https://academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/kead080/7048658

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