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Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019

Wei, Sunny; Miranda, J Jamie; Mamas, Mamas A; Zühlke, Liesl J; Kontopantelis, Evan; Thabane, Lehana; Van Spall, Harriette G C

Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019 Thumbnail


Authors

Sunny Wei

J Jamie Miranda

Liesl J Zühlke

Evan Kontopantelis

Lehana Thabane

Harriette G C Van Spall



Abstract

Background Heart failure (HF) is a global epidemic. Objective To assess global sex differences in HF epidemiology across country income levels. Methods and results Using Global Burden of Disease (GBD) data from 204 countries and territories 1990–2019, we assessed sex differences in HF prevalence, etiology, morbidity, and temporal trends across country sociodemographic index or gross national income. We derived age-standardized rates. Of 56.2 million (95% uncertainty interval [UI] 46.4–67.8 million) people with HF in 2019, 50.3% were females and 69.2% lived in low- and middle-income countries; age-standardized prevalence was greater in males and in high-income countries. Ischaemic and hypertensive heart disease were top causes of HF in males and females, respectively. There were 5.1 million (95% UI 3.3–7.3 million) years lived with disability, distributed equally between sexes. Between 1990 and 2019, there was an increase in HF cases, but a decrease in age-standardized rates per 100 000 in males (9.1%, from 864.2 to 785.7) and females (5.8%, from 686.0 to 646.1). High-income regions experienced a 16.0% decrease in age-standardized rates (from 877.5 to 736.8), while low-income regions experienced a 3.9% increase (from 612.1 to 636.0), largely consistent across sexes. There was a temporal increase in age-standardized HF from hypertensive, rheumatic, and calcific aortic valvular heart disease, and a decrease from ischaemic heart disease, with regional and sex differences. Conclusion Age-standardized HF rates have decreased over time, with larger decreases in males than females; and with large decreases in high-income and small increases in low-income regions. Sex and regional differences offer targets for intervention.

Citation

Wei, S., Miranda, J. J., Mamas, M. A., Zühlke, L. J., Kontopantelis, E., Thabane, L., & Van Spall, H. G. C. (2023). Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019. European Heart Journal - Quality of Care and Clinical Outcomes, 9(7), 662-672. https://doi.org/10.1093/ehjqcco/qcac088

Journal Article Type Article
Acceptance Date Dec 26, 2022
Online Publication Date Dec 28, 2022
Publication Date Nov 2, 2023
Journal European Heart Journal - Quality of Care and Clinical Outcomes
Print ISSN 2058-5225
Publisher Oxford University Press
Volume 9
Issue 7
Pages 662-672
DOI https://doi.org/10.1093/ehjqcco/qcac088
Keywords Epidemiology, Male, Female, Global Burden of Disease, Morbidity
Publisher URL https://academic.oup.com/ehjqcco/advance-article/doi/10.1093/ehjqcco/qcac088/6964647