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Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion: A meta-analysis.

Mamas, Mamas



AbstractBackgroundWomen are underrepresented in chronic total occlusion (CTO) trials and little is known about sex differences in the outcomes of CTO percutaneous coronary intervention (PCI). This meta‐analysis aims to compare the outcomes of CTO PCI in males and females.MethodsA comprehensive search of PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar was performed for studies comparing outcomes of CTO PCI in females versus males from inception to January 26, 2021. The current statistical analysis was performed using STATA version 15.1 software (Stata Corporation, TX); P < 0.05 indicated statistical significance.ResultsFourteen observational studies were included in the analysis with 75% males and 25% females. The mean age was 64.47 ± 10.5 years and 68.98 ± 9.5 years for males and females, respectively. The median follow‐up duration was 2.4 years. Males had a higher Japanese‐CTO (J‐CTO) score compared with females (MD = −0.17; 95% CI: −0.25 to −0.10). Females had statistically higher success rates of CTO PCI (RR = 1.03; 95% CI: 1.01 to1.05), required less contrast volume (MD = −18.64: 95% CI: −30.89 to −6.39) and fluoroscopy time (MD = −9.12; 95% CI: −16.90 to −1.34) compared with males. There was no statistical difference in in‐hospital (RR = 1.50; 95% CI: 0.73 to 3.09) or longer term (≥6 months) all‐cause mortality (RR = 1.10; 95% CI: 0.86 to 1.42) between the two groups.ConclusionsCTO PCI is feasible and safe in female patients with comparable outcomes in female versus male patients.

Journal Article Type Article
Acceptance Date Oct 30, 2021
Online Publication Date Nov 12, 2021
Publication Date Feb 1, 2022
Journal Catheterization and Cardiovascular Interventions
Print ISSN 1522-1946
Publisher Wiley
Volume 99
Issue 2
Pages 254-262
Keywords Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, General Medicine
Publisher URL