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The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses.

Bideshki, Mohammad Vesal; Jourabchi‐Ghadim, Neda; Radkhah, Nima; Behzadi, Mehrdad; Asemani, Sanaz; Jamilian, Parmida; Zarezadeh, Meysam; Jourabchi-Ghadim, Neda

Authors

Mohammad Vesal Bideshki

Neda Jourabchi‐Ghadim

Nima Radkhah

Mehrdad Behzadi

Sanaz Asemani

Parmida Jamilian

Meysam Zarezadeh

Neda Jourabchi-Ghadim



Abstract

Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases. Several meta-analyses have shown that curcumin could improve the function of the knee and alleviate pain in OA, while some meta-analyses demonstrate controversial results. Hence, we assessed curcumin's effects on knee OA in an umbrella meta-analysis. PubMed, Scopus, Embase, and Web of Science databases were employed to find English-language meta-analyses of randomized controlled trials investigating the effect of curcumin supplementation on OA outcomes up to September 2023. The visual analog scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain, function, and stiffness scales were analyzed. Effect sizes and 95% confidence intervals were utilized to obtain the overall effect size. A random-effects model was applied to perform the meta-analysis. Heterogeneity was determined by I statistics and the Cochrane Q-test. The pooled effect of the 11 included meta-analyses showed that curcumin could significantly decrease the VAS score (weighted mean difference [WMD] and standardized mean difference [SMD]), WOMAC-total (SMD and WMD), WOMAC-Function (SMD and WMD), WOMAC-Pain (SMD), and WOMAC-Stiffness scores (SMD) (p ≤ 0.001, ≤0.001, ≤0.001, 0.007, ≤0.001, 0.002, ≤0.001, ≤0.001, respectively). The results strongly support curcuminoid supplementation in relieving pain, improving joint mobility and stiffness, and shortening medication usage of OA patients. [Abstract copyright: © 2024 John Wiley & Sons Ltd.]

Citation

Bideshki, M. V., Jourabchi‐Ghadim, N., Radkhah, N., Behzadi, M., Asemani, S., Jamilian, P., …Jourabchi-Ghadim, N. (in press). The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses. Phytotherapy Research, https://doi.org/10.1002/ptr.8153

Journal Article Type Review
Acceptance Date Jan 28, 2024
Online Publication Date Apr 4, 2024
Deposit Date Apr 22, 2024
Journal Phytotherapy research : PTR
Print ISSN 0951-418X
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/ptr.8153
Keywords curcumin, osteoarthritis, WOMAC, umbrella meta‐analysis
Public URL https://keele-repository.worktribe.com/output/796585



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