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GNB2L1 (guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1)

Mourtada-Maarabouni, M

Authors



Abstract

GNB2L1 encodes a cytosolic protein with a molecular mass of approximatively 35 kDa (317 amino acids). The protein has seven internal Trp-Asp 40 (WD40 domain) repeats. The WD40 repeats of RACK1/GNB2L1 are predicted to form a seven-bladed propeller structure, where each blade is composed of a four-stranded anti-parallel beta-sheet. The highly conserved WD repeat sequence of RACK1/GNB2L1 is found in a number of eukaryotic proteins and is implicated in a wide variety of functions including adaptor/regulatory modules in signal transduction, premRNA processing and cytoskeleton assembly.

Journal Article Type Article
Deposit Date May 15, 2024
Journal Atlas of Genetics and Cytogenetics in Oncology and Haematology
Peer Reviewed Peer Reviewed
Issue 2
DOI https://doi.org/10.4267/2042/38501
Public URL https://keele-repository.worktribe.com/output/828244
Additional Information https://www.researchgate.net/publication/48272222_GNB2L1_guanine_nucleotide_binding_protein_G_protein_beta_polypeptide_2-like_1