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All Outputs (467)

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., …Muller, S. (in press). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Everyday Living with Osteoarthritis in the Global South: A qualitative focus group inquiry in Nigeria. (2024)
Journal Article
Owoyemi, T., Alonge, I., Adetunji, O., Ogbu, E., Ogunbanjo, A., White, S., …Dziedzic, K. (2024). Everyday Living with Osteoarthritis in the Global South: A qualitative focus group inquiry in Nigeria. Osteoarthritis and Cartilage Open, Article 100555. https://doi.org/10.1016/j.ocarto.2024.100555

Objective
Africa contributes significantly to the increasing global prevalence (>37%), unmet need and treatment burden for people with osteoarthritis. Despite this, little research has examined the expressed needs of patients with osteoarthritis (OA... Read More about Everyday Living with Osteoarthritis in the Global South: A qualitative focus group inquiry in Nigeria..

Incidence of side effects associated with acetaminophen in people aged 65 years or more: a prospective cohort study using data from the Clinical Practice Research Datalink (2024)
Journal Article
Kaur, J., Nakafero, G., Abhishek, A., Mallen, C., Doherty, M., & Zhang, W. (in press). Incidence of side effects associated with acetaminophen in people aged 65 years or more: a prospective cohort study using data from the Clinical Practice Research Datalink. Arthritis Care & Research, https://doi.org/10.1002/acr.25471

Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged 65 years or more. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Part... Read More about Incidence of side effects associated with acetaminophen in people aged 65 years or more: a prospective cohort study using data from the Clinical Practice Research Datalink.

Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope (2024)
Journal Article
Scott, I. C., Babatunde, O., Barker, C., Beesley, R., Beesley, R., Birkinshaw, H., …Shenker, N. G. (in press). Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(4), Article rkae128. https://doi.org/10.1093/rap/rkae128

Lay Summary: What does this mean for patients? Inflammatory arthritis includes conditions causing swollen and painful joints. The main types are rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis and juvenile idiopathic arthritis. It... Read More about Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope.

Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis? (2024)
Journal Article
Roddy, E., Prior, J. A., & Mallen, C. D. (2024). Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?. Exploration of Musculoskeletal Diseases, 2, 521-528. https://doi.org/10.37349/emd.2024.00076

Co-prescription of anti-inflammatory prophylaxis with colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), or corticosteroids when initiating urate-lowering therapy (ULT) for gout is recommended in clinical guidelines to prevent ULT-induced fl... Read More about Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?.

Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study (2024)
Journal Article
Bullock, L., Cherrington, A., Clark, E. M., Fleming, J., Bentley, I., Nicholls, E., …Paskins, Z. (in press). Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study. NIHR Open Research, 4, 70. https://doi.org/10.3310/nihropenres.13751.1

Background
High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and v... Read More about Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study.

Measles and Pertussis outbreaks in England and Wales: a time-series analysis (2024)
Journal Article
Shepherd, T., & Mallen, C. (2024). Measles and Pertussis outbreaks in England and Wales: a time-series analysis. NIHR Open Research, 4, 56. https://doi.org/10.3310/nihropenres.13607.1

Background
Vaccine coverage for common infectious diseases such as Measles and Pertussis (also known as whooping cough) have been declining in England and Wales since 2014. Consequently, significant increases in Measles and Pertussis cases are obser... Read More about Measles and Pertussis outbreaks in England and Wales: a time-series analysis.

Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Singh Sokhal, B., Prasanna Kumar Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, https://doi.org/10.3310/nihropenres.13623.1

Introduction
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence is rising, and studies have reported potential sex and race disparities in patient outcomes. D... Read More about Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review].

Interventions to promote colorectal cancer screening among people with a family history of colorectal cancer: A scoping review. (2024)
Journal Article
Firzara, A. M. T., Beh, H. C., Selvaraj, C. S., Mallen, C., Ng, C. J., & Lee, Y. K. (in press). Interventions to promote colorectal cancer screening among people with a family history of colorectal cancer: A scoping review. Preventive Medicine, 189(December 2024), 1-18. https://doi.org/10.1016/j.ypmed.2024.108137

The global incidence of colorectal cancer (CRC) is rising, with people having a family history of CRC (PFH-CRC) facing double the risk compared to the average-risk population. Despite this, CRC screening uptake among PFH-CRC remains low. There is a l... Read More about Interventions to promote colorectal cancer screening among people with a family history of colorectal cancer: A scoping review..

2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study (2024)
Journal Article
Sokhal, B., Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study. Age and ageing, 53(Supplement_3), iii19. https://doi.org/10.1093/ageing/afae139.073

Introduction Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence of PD is increasing and the literature demonstrates potential sex and race disparities in patie... Read More about 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study.

2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients (2024)
Journal Article
Sokhal, B., Matetić, A., Protheroe, J., Helliwell, T., Myint, P., Paul, T., …Mamas, M. (2024). 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.051

Introduction Data are limited on whether the causes of Emergency Department (ED) attendance and clinical outcomes vary by frailty status. Methods Using data from the Nationwide Emergency Department Sample, all ED attendances from 2016 to 2018 were st... Read More about 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients.

2235 National Trends in motor neurone disease-associated mortality from 1999–2020 (2024)
Journal Article
Imantalab, D., Sokhal, B., Menon, S., Kara, S., Muller, S., & Mallen, C. (2024). 2235 National Trends in motor neurone disease-associated mortality from 1999–2020. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.074

Introduction Motor Neurone Disease (MND) is a neurodegenerative condition affecting the spinal cord and brainstem, commonly associated with a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United S... Read More about 2235 National Trends in motor neurone disease-associated mortality from 1999–2020.

Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study. (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study. The Lancet Rheumatology, 6(9), e615-e624. https://doi.org/10.1016/S2665-9913%2824%2900128-0

People with immune-mediated inflammatory disease are at increased risk of pneumococcal pneumonia. The effectiveness of pneumococcal vaccination in people with immune-mediated inflammatory diseases has not been evaluated. We investigated the effective... Read More about Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study..

Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection (2024)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S. A., Jinks, C., Buttery, A., Ashworth, J., …Dikomitis, L. (2024). Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection. British Journal of Pain, 18(6), 461-471. https://doi.org/10.1177/20494637241254098

Introduction
Understanding patients’ experiences is important when developing interventions for people living with persistent pain. Interviews and focus groups are frequently used to capture beliefs, views, and perspectives. These methods often requ... Read More about Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection.

Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection (2024)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S., Jinks, C., Buttery, A., Ashworth, J., …Dikomitis, L. (2024). Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection. British Journal of Pain, https://doi.org/10.1177/204946372412540

Introduction Understanding patients’ experiences is important when developing interventions for people living with persistent pain. Interviews and focus groups are frequently used to capture beliefs, views, and perspectives. These methods often requi... Read More about Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection.

The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica (2024)
Journal Article
Scott, I. C., Bajpai, R., Hider, S. L., Helliwell, T., Mallen, C. D., & Muller, S. (in press). The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica. Rheumatology Advances in Practice, 8(3), Article rkae081. https://doi.org/10.1093/rap/rkae081

Objective
To examine the association between obesity and patient-reported outcomes measures (PROMs) in a primary care-based cohort of people with polymyalgia rheumatica (PMR).

Methods
The PMR Cohort Study recruited people with incident PMR from... Read More about The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica.

Relationship between research activity and the performance of English general practices: cross-sectional and longitudinal analyses (2024)
Journal Article
Gibson, J., Kontopantelis, E., Sutton, M., Boaz, A., Little, P., Mallen, C. D., …Bower, P. (in press). Relationship between research activity and the performance of English general practices: cross-sectional and longitudinal analyses. British Journal of General Practice (BJGP), BJGP.2024.0111. https://doi.org/10.3399/BJGP.2024.0111

Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that these relation... Read More about Relationship between research activity and the performance of English general practices: cross-sectional and longitudinal analyses.

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary
Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM (2024)
Journal Article
Scott, I., Daud, N., Bailey, J., Twohig, H., Hider, S., Mallen, C., …Muller, S. (2024). AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM. Annals of the Rheumatic Diseases, 83(Issue Suppl 1), https://doi.org/10.1136/annrheumdis-2024-eular.4000

associate with an increased risk of fractures. The potential for confounding inherent to non-randomised studies of interventions, however, alongside the conflicting findings of these studies (with some reporting an increased risk [1] and others no re... Read More about AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM.