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A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation (2019)
Journal Article
Naire, & Kuiper. (2019). A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation. Journal of Tissue Engineering, 1-14. https://doi.org/10.1177/2041731419827792

We present a mathematical model of cartilage regeneration after cell therapy, to show how co-implantation of stem cells (mesenchymal stem cells) and chondrocytes into a cartilage defect can impact chondral healing. The key mechanisms involved in the... Read More about A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation.

A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors (2019)
Journal Article
Campbell, K., Kuiper, J., & Naire, S. (2019). A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors. Journal of Tissue Engineering, 1-16. https://doi.org/10.1177/2041731419827791

Autologous Chondrocyte Implantation is a cell-based therapy for treating chondral defects. The procedure begins by inserting chondrocytes into the defect region. The chondrocytes initiate healing by proliferating and depositing extracellular matrix,... Read More about A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors.

Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements (2019)
Journal Article
Kuiper. (2019). Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements. Journal of Clinical Orthopaedics and Trauma, 350-357. https://doi.org/10.1016/j.jcot.2017.12.008

Introduction
40?mm large diameter heads offer the advantages of lesser dislocation rates and better stability while highly cross linked polyethylene have lower wear rates than ultra high molecular weight polyethylene. Studies of the survivorship of... Read More about Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements.

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. (2018)
Journal Article
Kuiper, J., & Wright, K. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. European cells & materials, 255 - 267. https://doi.org/10.22203/eCM.v035a18

High hopes have been pinned on regenerative medicine strategies in order to prevent the progression of cartilage damage to osteoarthritis, particularly by autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro mo... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy..

External rotation bracing for first-time anterior dislocation of the shoulder: A discontinued randomised controlled trial comparing external rotation bracing with conventional sling (2018)
Journal Article
Chan, S. K., Bentick, K. R., Kuiper, J. H., & Kelly, C. P. (2019). External rotation bracing for first-time anterior dislocation of the shoulder: A discontinued randomised controlled trial comparing external rotation bracing with conventional sling. Shoulder and Elbow, 11(4), 256-264. https://doi.org/10.1177/1758573218768521

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy (2018)
Journal Article
Sykes, J., Kuiper, J., Richardson, J., Wright, K., & Kuiper, N. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Osteoarthritis and Cartilage, 26(S1), https://doi.org/10.1016/j.joca.2018.02.221

Purpose
High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing the progression to osteoarthritis, in particular autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy.

The twin peg Oxford knee — Medium term survivorship and surgical principles (2018)
Journal Article
Kuiper. (2018). The twin peg Oxford knee — Medium term survivorship and surgical principles. https://doi.org/10.1016/j.knee.2018.01.001

A multicentre study of single peg Oxford knees reported failure associated with osteoarthritis progression, femoral component loosening, unexplained pain and meniscal bearing dislocation. Suboptimally positioned femoral components and intraoperative... Read More about The twin peg Oxford knee — Medium term survivorship and surgical principles.

Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures (2017)
Journal Article
Kuiper. (2017). Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures. Journal of Experimental Orthopaedics, https://doi.org/10.1186/s40634-017-0101-9

Background: Rupture of the Achilles tendon often leads to long-term morbidity, particularly calf weakness associated with tendon elongation. Operative repair of Achilles tendon ruptures leads to reduced tendon elongation. Tendon lengthening is a key... Read More about Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures.

Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation (2017)
Journal Article
Garcia, J., Hulme, C., Roberts, S., Richardson, J., Kuiper, J., & Wright, K. (2017). Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation. International Journal of Experimental Pathology, 98(3), A23

Introduction

Autologous chondrocyte implantation (ACI) and microfracture are both used in the treatment of cartilage injuries. Previous findings suggest that the efficacy of these two therapies is similar in terms of short-term clinical outcome, h... Read More about Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation.

Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. (2017)
Journal Article
Richardson, J. B., Wright, K. T., Wales, J., Herman Kuiper, J., McCarthy, H. S., Gallacher, P., …Roberts, S. (2017). Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regenerative Medicine, 12(5), 493-501. https://doi.org/10.2217/rme-2017-0032

AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral def... Read More about Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design..

Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint (2017)
Journal Article
Wright, K. T., Wilson, E., Hulme, C., Kuiper, J. H., Gallacher, P., Richardson, J. B., & Roberts, S. (2017). Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint. International Journal of Experimental Pathology, 97(6), A24

Introduction This study aims to examine the impact of the cartilage harvest procedure on synovial fluid biomarkers at the time of autologous chondrocyte implantation (ACI).

Materials and Methods Hyaluronic acid (HA), cartilage oligomeric matrix pr... Read More about Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint.

The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success (2017)
Journal Article
Kuiper, J., Roberts, S., & Wright, K. (2017). The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success. American Journal of Sports Medicine, 1806-1814

Background:
Autologous chondrocyte implantation (ACI) is used worldwide in the treatment of cartilage defects in the knee. Several demographic and injury-specific risk factors have been identified that can affect the success of ACI treatment. Howeve... Read More about The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success.

Surgical treatment for developmental dysplasia of the hip- a single surgeon series of 47 hips with a 7 year mean follow up). (2016)
Journal Article
Kuiper. (2016). Surgical treatment for developmental dysplasia of the hip- a single surgeon series of 47 hips with a 7 year mean follow up)

The treatment of developmental dysplasia of the hip (DDH) in children remains controversial. We describe the clinical and radiological outcomes of  47 hips in 43 children treated with open surgery by one surgeon between 2004 and 2008 for DDH. The mea... Read More about Surgical treatment for developmental dysplasia of the hip- a single surgeon series of 47 hips with a 7 year mean follow up)..

Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology. (2016)
Journal Article
Adams, C., Dickson, A., Kuiper, J., & Chari, D. (2016). Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology. Nanoscale, 8, 17869-17880. https://doi.org/10.1039/c6nr05244d

Tissue engineering studies are witnessing a major paradigm shift to cell culture on biomimetic materials that replicate native tissue features from which the cells are derived. Few studies have been performed in this regard for neural cells, particul... Read More about Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology..

Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella (2016)
Journal Article
Kuiper. (2016). Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella. Chinese Journal of Traumatology (English Edition), 255-258. https://doi.org/10.1016/j.cjtee.2016.06.009

Abstract
Purpose
Tension band wiring is commonly used for fixation of simple transverse fractures. The popular configuration is parallel Kirschner wires (K-wires) and a stainless steel wire loop placed in a vertically oriented figure-of-8.

Metho... Read More about Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella.

A systematic review – ovarian suppression with GnRH analogues for management of PMS (2016)
Journal Article
Naheed, B., Kuiper, J., & O'Brien, S. (2016). A systematic review – ovarian suppression with GnRH analogues for management of PMS. BJOG: An International Journal of Obstetrics and Gynaecology, 123, 186. https://doi.org/10.1111/1471-0528.14109

Introduction Premenstrual syndrome (PMS) is a psychological and somatic disorder.It occurs in about 5–8% of women .PMS symptoms recur during the luteal phase of the menstrual cycle and remit by the end of menstruation. Premenstrual Disorders have a d... Read More about A systematic review – ovarian suppression with GnRH analogues for management of PMS.

Development of a tool to predict outcome of Autologous Chondrocyte Implantation (2016)
Journal Article
Kuiper. (2016). Development of a tool to predict outcome of Autologous Chondrocyte Implantation. Cartilage, 119-130. https://doi.org/10.1177/1947603516650002

Objective. The study had 2 objectives: first, to evaluate the success of autologous chondrocyte implantation (ACI) in
terms of incidence of surgical re-intervention, including arthroplasty, and investigate predictors of successful treatment
outcome... Read More about Development of a tool to predict outcome of Autologous Chondrocyte Implantation.

Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. (2016)
Journal Article
Garcia, J., Wright, K., Roberts, S., Herman Kuiper, J., Mangham, C., Richardson, J., & Mennan, C. (2016). Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Scientific reports, 6, 24295 -?. https://doi.org/10.1038/srep24295

The infrapatellar fat pad (FP) and synovial fluid (SF) in the knee serve as reservoirs of mesenchymal stromal cells (MSCs) with potential therapeutic benefit. We determined the influence of the donor on the phenotype of donor matched FP and SF derive... Read More about Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus..