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The ligamentum teres and its role in hip arthroscopy for femoroacetabular impingement: a systematic review (2024)
Journal Article
Migliorini, F., Cocconi, F., Bardazzi, T., Masoni, V., Gardino, V., Pipino, G., & Maffulli, N. (in press). The ligamentum teres and its role in hip arthroscopy for femoroacetabular impingement: a systematic review. Journal of Orthopaedics and Traumatology, 25(1), Article 68. https://doi.org/10.1186/s10195-024-00810-1

Background: The ligamentum teres (LT) has received attention in patients undergoing hip arthroscopy (HA) for femoroacetabular impingement (FAI). Indeed, a better understanding of the function of the LT and its implications for clinical outcomes in th... Read More about The ligamentum teres and its role in hip arthroscopy for femoroacetabular impingement: a systematic review.

Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. (2024)
Journal Article
Migliorini, F., Schäfer, L., Pilone, M., Bell, A., Simeone, F., & Maffulli, N. (in press). Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Archives of Orthopaedic and Trauma Surgery, 145(1), 68. https://doi.org/10.1007/s00402-024-05614-w

The present meta-analysis compared the efficacy of intra-articular hyaluronic acid (HA) injections in patients with early to mild knee osteoarthritis (OA) (Kellgren Lawrence I-II) versus other commonly injected biologically active compounds using pat... Read More about Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis..

Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts (2024)
Journal Article
Muruganandam, A., Migliorini, F., Jeyaraman, N., Vaishya, R., Balaji, S., Ramasubramanian, S., Maffulli, N., & Jeyaraman, M. (in press). Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts. Medical Sciences, 12(4), 1-15. https://doi.org/10.3390/medsci12040072

Rheumatoid arthritis (RA) represents an autoimmune condition impacted by a combination of genetic and environmental factors, with the gut microbiome (GMB) being one of the influential environmental factors. Patients with RA display notable modificati... Read More about Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts.

Arthroscopic lateral ligament reconstruction for isolated chronic lateral ankle instability is associated with longer recovery compared to arthroscopic Broström repair and inferior extensor retinaculum augmentation. (2024)
Journal Article
Feng, S.-M., Sun, Q.-Q., Xue, C., Maffulli, N., Oliva, F., & Luo, X. (2025). Arthroscopic lateral ligament reconstruction for isolated chronic lateral ankle instability is associated with longer recovery compared to arthroscopic Broström repair and inferior extensor retinaculum augmentation. Injury, 56(2), 112082. https://doi.org/10.1016/j.injury.2024.112082

Patients with chronic lateral ankle instability (CLAI) can be managed with arthroscopic Broström repair and inferior extensor retinaculum augmentation or arthroscopic assisted lateral ligament reconstruction using ipsilateral semitendinosus autograft... Read More about Arthroscopic lateral ligament reconstruction for isolated chronic lateral ankle instability is associated with longer recovery compared to arthroscopic Broström repair and inferior extensor retinaculum augmentation..

Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review (2024)
Journal Article
Migliorini, F., Pilone, M., Schäfer, L., Bertini, F. A., Giorgino, R., & Maffulli, N. (in press). Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review. British Medical Bulletin, 1-11. https://doi.org/10.1093/bmb/ldae020

Introduction Anterior cruciate ligament (ACL) injuries in children and adolescents with open physes are common. Areas of agreement Evidence of ACL reconstruction using allografts in children with open physes is limited. Areas of controversy Whether t... Read More about Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review.

Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. (2024)
Journal Article
Maffulli, N., Christidis, G., Gougoulias, N., Christidis, P., Poku, D., Hassan, R., Migliorini, F., & Oliva, F. (in press). Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. British Medical Bulletin, 1-9. https://doi.org/10.1093/bmb/ldae019

The present prospective comparative study included patients with acute Achilles tendon rupture (ATR) who underwent percutaneous repair with one knot compared to percutaneous repair with two knots. All patients underwent the procedure under local anes... Read More about Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study..

No Effect of Cigarette Smoking in the Outcome of Arthroscopic Management for Femoroacetabular Impingement: A Systematic Review (2024)
Journal Article
Lucenti, L., Maffulli, N., Bardazzi, T., Pipino, G., Pappalardo, G., & Migliorini, F. (in press). No Effect of Cigarette Smoking in the Outcome of Arthroscopic Management for Femoroacetabular Impingement: A Systematic Review. Journal of Clinical Medicine, 13(23), https://doi.org/10.3390/jcm13237214

Background: The impact of smoking in arthroscopic surgery for femoroacetabolar impingement (FAI) is controversial. This systematic review updates and discusses current evidence on the influence of cigarette smoking on the outcome of arthroscopic mana... Read More about No Effect of Cigarette Smoking in the Outcome of Arthroscopic Management for Femoroacetabular Impingement: A Systematic Review.

Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis. (2024)
Journal Article
Migliorini, F., Giorgino, R., Mazzoleni, M. G., Schäfer, L., Bertini, F. A., & Maffulli, N. (in press). Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis. European Journal of Orthopaedic Surgery and Traumatology, 35(1), Article 20. https://doi.org/10.1007/s00590-024-04135-x

Intra-articular injections of ozone and hyaluronic acid (HA) are routinely performed for the management of knee osteoarthritis. The present meta-analysis compared intra-articular injections of HA versus ozone in patients with knee osteoarthritis (OA)... Read More about Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis..

Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2024)
Journal Article
Migliorini, F., Maffulli, N., Schäfer, L., Kubach, J., Betsch, M., & Pasurka, M. (in press). Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Pharmaceuticals, 17(11), Article 1557. https://doi.org/10.3390/ph17111557

The present meta-analysis investigated the efficacy of intra-articular hyaluronic acid (HA) injections for knee osteoarthritis. The outcomes of interest were the visual analogue scale (VAS) and Western Ontario McMaster Osteo-Arthritis Index (WOMAC) s... Read More about Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Autologous Peripheral Blood-Derived Orthobiologics for the Management of Shoulder Disorders: A Review of Current Clinical Evidence. (2024)
Journal Article
Gupta, A., & Maffulli, N. (2024). Autologous Peripheral Blood-Derived Orthobiologics for the Management of Shoulder Disorders: A Review of Current Clinical Evidence. Pain and Therapy, 1-13. https://doi.org/10.1007/s40122-024-00684-5

A multidisciplinary approach is recommended to manage shoulder pain, the third most common musculoskeletal disorder, but traditional modalities have limitations, providing only temporary symptomatic pain relief instead of targeting the underlying pat... Read More about Autologous Peripheral Blood-Derived Orthobiologics for the Management of Shoulder Disorders: A Review of Current Clinical Evidence..

Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review (2024)
Journal Article
Baroncini, A., Maffulli, N., Pilone, M., Pipino, G., Memminger, M. K., Pappalardo, G., & Migliorini, F. (2024). Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review. Journal of Clinical Medicine, 13(22), 1-27. https://doi.org/10.3390/jcm13226864

Background: Low back pain is common. For patients with mechanic or non-specific chronic LBP (cLBP), the current guidelines suggest conservative, nonpharmacologic treatment as a first-line treatment. Among the available strategies, physiotherapy repre... Read More about Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review.

Subsidence of the Corail stem in total hip arthroplasty: no influence of bony contact (2024)
Journal Article
Migliorini, F., Maffulli, N., Pilone, M., Kämmer, D., Hofmann, U. K., Nobili, A., Velaj, E., & Bell, A. (2024). Subsidence of the Corail stem in total hip arthroplasty: no influence of bony contact. Journal of Orthopaedics and Traumatology, 25(1), 1-9. https://doi.org/10.1186/s10195-024-00794-y

Introduction: This study investigated stem subsidence following primary total hip arthroplasty (THA) with a Corail stem in patients who underwent two-staged bilateral THA. The second outcome of interest was to investigate whether a specific single co... Read More about Subsidence of the Corail stem in total hip arthroplasty: no influence of bony contact.

Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review (2024)
Journal Article
Migliorini, F., Pilone, M., Ascani, J., Schäfer, L., Jeyaraman, M., & Maffulli, N. (2024). Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review. British Medical Bulletin, 1-13. https://doi.org/10.1093/bmb/ldae016

Introduction Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability in the general population. Source of data Recent published literature identified from PubMed, EMBASE, Google Scholar, and Scopus. Areas of... Read More about Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review.

High-volume injections in Achilles tendinopathy: a systematic review (2024)
Journal Article
Hassan, R., Poku, D., Miah, N., & Maffulli, N. (2024). High-volume injections in Achilles tendinopathy: a systematic review. British Medical Bulletin, 1-13. https://doi.org/10.1093/bmb/ldae015

Introduction Achilles tendinopathy (AT) is common, particularly in runners. High-volume injections (HVIs) may be beneficial in the management of AT compared to other conservative management options, including exercise regimens, platelet-rich plasma (... Read More about High-volume injections in Achilles tendinopathy: a systematic review.

ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells (2024)
Journal Article
Cortella, G., Lamparelli, E. P., Ciardulli, M. C., Lovecchio, J., Giordano, E., Maffulli, N., & Della Porta, G. (in press). ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells. Bioengineering and Translational Medicine, 1-15. https://doi.org/10.1002/btm2.10723

The advent of bioprinting has enabled the creation of precise three‐dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) comb... Read More about ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.

Manipulation of signaling pathways in bone tissue engineering and regenerative medicine: Current knowledge, novel strategies, and future directions. (2024)
Journal Article
Oryan, A., Afzali, S. A., & Maffulli, N. (in press). Manipulation of signaling pathways in bone tissue engineering and regenerative medicine: Current knowledge, novel strategies, and future directions. Injury, 55(12), Article 111976. https://doi.org/10.1016/j.injury.2024.111976

During osteogenesis, a large number of bioactive molecules, macromolecules, cells, and cellular signals are activated to induce bone growth and development. The activation of molecular pathways leads to the occurrence of cellular events, ultimately r... Read More about Manipulation of signaling pathways in bone tissue engineering and regenerative medicine: Current knowledge, novel strategies, and future directions..

Loss of Consciousness in Judo: Not Always a Concussion (2024)
Journal Article
Singh, K., Malliaropoulos, N., Callan, M., Ikumi, A., & Maffulli, N. (in press). Loss of Consciousness in Judo: Not Always a Concussion. Clinical Journal of Sport Medicine, 1-2. https://doi.org/10.1097/jsm.0000000000001281

INTRODUCTION
All sports carry injury risks. In the event of loss of consciousness (LOC) in judo, and with an appropriate mechanism of injury, concussion is likely to be high on a list of potential causes. The diagnosis and management of concussion h... Read More about Loss of Consciousness in Judo: Not Always a Concussion.

Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports (2024)
Journal Article
Lorenzo-Capellá, I., Ramos-Álvarez, J. J., Jiménez-Herranz, M. E., Maffulli, N., de Borba, E. F., Iuliano, E., Calderón-Montero, F. J., Ardigò, L. P., Russo, L., & Padulo, J. (in press). Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports. European Journal of Applied Physiology, https://doi.org/10.1007/s00421-024-05625-w

Purpose
The use of a fixed theoretical-proportional-factor (TPF15) is one of the indirect highest-oxygen-consumptions (HOC) assessment methods, but it may not accurately reflect the physiological differences across various sports (cycling-triathlon-... Read More about Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports.

Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence (2024)
Journal Article
Labianca, L., Calderaro, C., & Maffulli, N. (2024). Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence. British Medical Bulletin, 152(1), 28-34. https://doi.org/10.1093/bmb/ldae014

Introduction Fractures of the distal radius are common in pediatric population, with considerable variation in the management of pediatric wrist fractures across different countries. It is crucial to consider the different approaches to conservative... Read More about Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence.