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Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. (1994)
Journal Article
Warwick, A., Redman, C., Jones, P., Fryer, A., Gilford, J., Alldersea, J., & Strange, R. (1994). Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. British journal of cancer, 70, 704 -708. https://doi.org/10.1038/bjc.1994.378

The factors that determine progression of cervical intraepithelial neoplasia (CIN) to squamous cell carcinoma (SCC) are unknown. Cigarette smoking is an independent risk factor for cervical neoplasia, suggesting that polymorphism at detoxicating enzy... Read More about Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking..

Alpha, Mu and Pi Class Glutathione S-Transferases in Human Synovium and Cultured Synovial Fibroblasts: Effects of Interleukin-1α, Hydrogen Peroxide and Inhibition of Eicosanoid Synthesis (1993)
Journal Article
Mattey, D. L., Nixon, N., Alldersea, J. E., Cotton, W., Fryer, A. A., Zhao, L., …Strange, R. C. (1993). Alpha, Mu and Pi Class Glutathione S-Transferases in Human Synovium and Cultured Synovial Fibroblasts: Effects of Interleukin-1α, Hydrogen Peroxide and Inhibition of Eicosanoid Synthesis. Free Radical Research, 19(3), https://doi.org/10.3109/10715769309111599

We describe expression of alpha, mu and pi class glutathione S-transferases (GST) and, CuZn- and Mn superoxide dismutase (SOD) in human synovium and cultured synovial fibroblasts. Immunohistochemical and immunoblotting studies showed synovium and cul... Read More about Alpha, Mu and Pi Class Glutathione S-Transferases in Human Synovium and Cultured Synovial Fibroblasts: Effects of Interleukin-1α, Hydrogen Peroxide and Inhibition of Eicosanoid Synthesis.

Alpha, mu and pi class glutathione s-transferases in human synovium and cultured synovial fibroblasts: Effects of interleukin-1α hydrogen peroxide and inhibition of eicosanoid synthesis (1993)
Journal Article
Mattey, D. L., Nixon, N., Alldersea, J. E., Cotton, W., Fryer, A. A., Zhao, L., …Strange, R. C. (1993). Alpha, mu and pi class glutathione s-transferases in human synovium and cultured synovial fibroblasts: Effects of interleukin-1α hydrogen peroxide and inhibition of eicosanoid synthesis. Free Radical Research, 19(3), https://doi.org/10.3109/10715769309111599

Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus (1993)
Journal Article
Fryer, A. A., Zhao, L., Alldersea, J., Pearson, W. R., & Strange, R. C. (1993). Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus. Biochemical Journal, 295(1), 313–315

We describe the identification of the GSTM1 null, GSTM1 A, GSTM1 B and GSTM1 A,B polymorphisms at the glutathione S-transferase GSTM1 locus using a single-step PCR method. Target DNA was amplified using primers to intron 6 and exon 7 with site-direct... Read More about Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus.

Plasma protein levels in normal human fetuses: 13 to 41 weeks' gestation. (1993)
Journal Article
Fryer, A., Jones, P., Strange, R., Hume, R., & Bell, J. (1993). Plasma protein levels in normal human fetuses: 13 to 41 weeks' gestation. BJOG: An International Journal of Obstetrics and Gynaecology, 100(9), 850-855. https://doi.org/10.1111/j.1471-0528.1993.tb14313.x

Objective To establish reference ranges for the levels of alpha-fetoprotein, albumin, prealbumin (transthyretin) alpha-1-antitrypsin, transferrin, ceruloplasmin and total protein in the plasma of normal human fetuses and newborn babies.

Design Pro... Read More about Plasma protein levels in normal human fetuses: 13 to 41 weeks' gestation..

The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas. (1993)
Journal Article
Fryer, A. A., Zhao, L., Alldersea, J., Boggild, M. D., Perrett, C. W., Clayton, R. N., …Strange, R. C. (1993). The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas. Carcinogenesis, https://doi.org/10.1093/carcin/14.4.563

The frequency of the GSTM1 0 polymorphism at the glutathione S-transferase M1 locus has been determined in controls and patients with pituitary adenomas by using the polymerase chain reaction to amplify genomic DNA in the exon 4–5 region of the gene.... Read More about The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas..

GSTM1 null polymorphism at the glutathione S-transferase M1 locus: phenotype and genotype studies in patients with primary biliary cirrhosis. (1993)
Journal Article
Davies, M. H., Elias, E., Acharya, S., Cotton, W., Faulder, G. C., Fryer, A. A., & Strange, R. C. (1993). GSTM1 null polymorphism at the glutathione S-transferase M1 locus: phenotype and genotype studies in patients with primary biliary cirrhosis. Gut, 34(4), https://doi.org/10.1136/gut.34.4.549

Studies were carried out to test the hypothesis that the GSTM1 null phenotype at the mu (mu) class glutathione S-transferase 1 locus is associated with an increased predisposition to primary biliary cirrhosis. Starch gel electrophoresis was used to c... Read More about GSTM1 null polymorphism at the glutathione S-transferase M1 locus: phenotype and genotype studies in patients with primary biliary cirrhosis..

Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. (1990)
Journal Article
Strange, R. C., Cotton, W., Fryer, A. A., Jones, P., Bell, J., & Hume, R. (1990). Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. Journal of Laboratory and Clinical Medicine, 116(5), 666-673

The putative involvement of reactive oxygen species in the etiology of lung damage in infants receiving mechanical ventilation has been examined by comparing the levels of peroxidation and expression of the antioxidant enzymes, CuZn and Mn superoxide... Read More about Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia..

The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. (1988)
Journal Article
Hiley, C., Fryer, A., Bell, J., Hume, R., & Strange, R. C. (1988). The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. Biochemical Journal, 254(1), 255–259. https://doi.org/10.1042/bj2540255

Immunohistochemical studies of the developmental expression of the Alpha- and Pi-class glutathione S-transferases in human liver have shown that the Pi enzyme is expressed in bile-duct epithelium and some hepatocytes but not in haematopoietic cells.... Read More about The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver..

Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development. (1988)
Journal Article
Strange, R. C., Cotton, W., Fryer, A. A., Drew, R., Bradwell, A. R., Marshall, T., …Hume, R. (1988). Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development. BBA - Biochimica et Biophysica Acta, https://doi.org/10.1016/0304-4165%2888%2990174-2

The developmental expression of Cu,Zn superoxide dismutase in human lung and erythrocytes has been studied using activity measurements, immunoblotting and immunohistochemistry. Enzyme activity in erythrocytes increased significantly during gestation... Read More about Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development..

Studies on the developmental expression of glutathione S-transferase isoenzymes in human heart and diaphragm. (1987)
Journal Article
Hirrell, P. A., Hume, R., Fryer, A. A., Collins, M. F., Drew, R., Bradwell, A., & Strange, R. C. (1987). Studies on the developmental expression of glutathione S-transferase isoenzymes in human heart and diaphragm. BBA - Biochimica et Biophysica Acta, 915(3), https://doi.org/10.1016/0167-4838%2887%2990022-7

The developmental expression of the basic near-neutral and acidic isoenzymes of glutathione S-transferase (RX:glutathione R-transferase, EC 2.5.1.18) has been studied in heart and diaphragm. Neither these enzymes nor the putative muscle-specific GST4... Read More about Studies on the developmental expression of glutathione S-transferase isoenzymes in human heart and diaphragm..

The development of glutathione S-transferase and glutathione peroxidase activities in human lung. (1986)
Journal Article
Fryer, A. A., Hume, R., & Strange, R. C. (1986). The development of glutathione S-transferase and glutathione peroxidase activities in human lung. BBA - Biochimica et Biophysica Acta, 883(3), 448-453. https://doi.org/10.1016/0304-4165%2886%2990283-7

The development of glutathione S-transferase and glutathione peroxidase activities has been studied in human lung cytosols. Whilst no clear change in glutathione peroxidase activity was identified, expression of the acidic glutathione S-transferase i... Read More about The development of glutathione S-transferase and glutathione peroxidase activities in human lung..