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Adult-onset testosterone deficiency: the usefulness of hormone replacement in reducing mortality in men with this common age-related condition (2024)
Journal Article
Mann, A., Strange, R. C., Hackett, G., König, C., & Ramachandran, S. (2024). Adult-onset testosterone deficiency: the usefulness of hormone replacement in reducing mortality in men with this common age-related condition. Exploration of Endocrine and Metabolic Diseases, 2024(1), 83-100. https://doi.org/10.37349/eemd.2024.00010

Adult-onset testosterone deficiency (TD) in men is diagnosed by the finding of low serum testosterone levels and recognised, associated symptoms. The condition has high prevalence in men over 50 years of age, particularly those with type 2 diabetes (... Read More about Adult-onset testosterone deficiency: the usefulness of hormone replacement in reducing mortality in men with this common age-related condition.

Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency (2024)
Journal Article
Haider, K. S., Zitzmann, M., Ramachandran, P., König, C. S., Hackett, G., Haider, A., …Ramachandran, S. (2024). Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency. The aging male : the official journal of the International Society for the Study of the Aging Male, 27(1), Article 2357548. https://doi.org/10.1080/13685538.2024.2357548

Objective
We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD.

Methods
Analyses were performed using non-parametric stati... Read More about Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency.

Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase (2024)
Journal Article
Tishova, Y., Kalinchenko, S., Mskhalaya, G., Hackett, G., Livingston, M., König, C., …Ramachandran, S. (2024). Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase. Diabetes, Obesity and Metabolism, 26(6), 2147-2157. https://doi.org/10.1111/dom.15520

Aims
To describe changes in homeostasis model assessment of insulin resistance index (HOMA-IR) following testosterone therapy in men with hypogonadism and metabolic syndrome (MetS).

Materials and Methods
A randomized, placebo-controlled, double-... Read More about Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase.

Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men (2024)
Journal Article
Hackett, G., Mann, A., Haider, A., Haider, K. S., Desnerck, P., König, C. S., …Ramachandran, S. (in press). Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men. The World Journal of Men's Health, 42, https://doi.org/10.5534/wjmh.230239

While testosterone therapy can improve the various pathologies associated with adult-onset testosterone deficiency (TD), Summary of Product Characteristics (SPC) of five testosterone preparations caution that treatment may be associated with hyperten... Read More about Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men.

Testosterone replacement therapy: association with mortality in high‐risk patient subgroups (2023)
Journal Article
Mann, A., Strange, R. C., König, C. S., Hackett, G., Haider, A., Haider, K. S., …Ramachandran, S. (in press). Testosterone replacement therapy: association with mortality in high‐risk patient subgroups. Andrology, https://doi.org/10.1111/andr.13582

Objectives
We describe studies determining the association between testosterone therapy (TTh) and mortality.

Materials & methods
We used a registry database of 737 men with adult-onset testosterone deficiency defined as presenting with low serum... Read More about Testosterone replacement therapy: association with mortality in high‐risk patient subgroups.

Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors (2018)
Journal Article
Hackett, G., Cole, N., Mulay, A., Strange, R. C., & Ramachandran, S. (2019). Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors. BJU International, 123(3), 519-529. https://doi.org/10.1111/bju.14536

Objective
To further characterise the beneficial impact of testosterone replacement therapy (TRT) on the association between mortality and hypogonadism (HG) in men with type 2 diabetes (T2DM). We aimed to determine firstly, if changes in cardiovascu... Read More about Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors.

P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound (2017)
Journal Article
Koenig, C., Atherton, M., Cavazzuti, M., Ramachandran, S., Gomm, C., Strange, R., …Schenkel, T. (2017). P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound. Artery Research, 20(C), 76-76. https://doi.org/10.1016/j.artres.2017.10.099

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CF... Read More about P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound.

Metabolic syndrome: a review of the role of vitamin D in mediating susceptibility and outcome (2015)
Journal Article
Strange, R. C., Shipman, K. E., & Ramachandran, S. (2015). Metabolic syndrome: a review of the role of vitamin D in mediating susceptibility and outcome. World Journal of Diabetes, 6(7), 896 - 911. https://doi.org/10.4239/wjd.v6.i7.896

Despite the well-recognised role of vitamin D in a wide range of physiological processes, hypovitaminosis is common worldwide (prevalence 30%-50%) presumably arising from inadequate exposure to ultraviolet radiation and insufficient consumption. Whil... Read More about Metabolic syndrome: a review of the role of vitamin D in mediating susceptibility and outcome.

Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study (2007)
Journal Article
Kapoor, B., Dunlop, C., Wynn-Jones, C., Fryer, A. A., Strange, R. C., & Maffulli, N. (2007). Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study. Journal of Negative Results in BioMedicine, 6, Article 7. https://doi.org/10.1186/1477-5751-6-7

We investigated the association of developmental dysplasia of the hip (DDH) and primary protrusion acetabuli (PPA) with Vitamin D receptor polymorphisms Taq I and Fok I and oestrogen receptor polymorphisms Pvu II and Xba I. 45 patients with DDH and 2... Read More about Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study.

Asthma severity and atopy: how clear is the relationship? (2006)
Journal Article
Carroll, W. D., Lenney, W., Child, F., Strange, R. C., Jones, P. W., Whyte, M. K., …Fryer, A. A. (2006). Asthma severity and atopy: how clear is the relationship?. Archives of Disease in Childhood, 91(5), 405 - 409. https://doi.org/10.1136/adc.2005.088278

BACKGROUND: The relationship between asthma severity and atopy is complex. Many studies have failed to show significant relationships between clinical severity or lung function and markers of atopic sensitisation. AIM: To determine whether increasing... Read More about Asthma severity and atopy: how clear is the relationship?.

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. (2005)
Journal Article
Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., …Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investiga... Read More about Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families..

Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. (2005)
Journal Article
Carroll, W., Lenney, W., Child, F., Strange, R., Jones, P., & Fryer, A. (2005). Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatric Allergy and Immunology, 16(1), 32 - 39. https://doi.org/10.1111/j.1399-3038.2005.00249.x

Maternal factors are known to influence the heritability and expression of asthma and atopy. We report the association of maternal, paternal and proband GSTP1 genotype with lung function in 145 Caucasian children with asthma. GSTP1 Val105/Val105 and... Read More about Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma..

Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes (2001)
Journal Article
Luscombe, C. J., French, M. E., Liu, S., Saxby, M. F., Jones, P. W., Fryer, A. A., & Strange, R. C. (2001). Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. British journal of cancer, 85, 1504 - 1509. https://doi.org/10.1054/bjoc.2001.2097

Exposure to ultraviolet radiation may reduce prostate cancer risk, suggesting that polymorphism in genes that mediate host pigmentation will be associated with susceptibility to this cancer. We studied 210 prostate cancer cases and 155 controls to de... Read More about Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes.

Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma (2001)
Journal Article
Hemmingsen, A., Fryer, A. A., Hepple, M., Strange, R. C., & Spiteri, M. A. (2001). Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma. Respiratory Research, 255 -260. https://doi.org/10.1186/rr64

BACKGROUND
The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105-->Val105 substitution are associated with the asthma phenotypes of atopy and bronc... Read More about Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma.

The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms (1999)
Journal Article
Layton, M. A., Jones, P. W., Alldersea, J. E., Strange, R. C., Fryer, A. A., Dawes, P. T., & Mattey, D. L. (1999). The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Rheumatology, 38(1), 43 - 47. https://doi.org/10.1093/rheumatology/38.1.43

To investigate whether the therapeutic response of rheumatoid arthritis (RA) patients to D-penicillamine is associated with polymorphisms in genes of the glutathione S-transferase (GST) supergene family.

Polymorphism in glutathione S-transferase loci as a risk factor for common cancers. (1998)
Conference Proceeding
Strange, R. C., Lear, J. T., & Fryer, A. A. (1998). Polymorphism in glutathione S-transferase loci as a risk factor for common cancers. In Diversification in Toxicology — Man and Environment (419–428). https://doi.org/10.1007/978-3-642-46856-8_37

Allelism has been found in human glutathione S-transferase (GST) genes of the alpha, mu, theta and pi families with the best characterised examples being those in mu class GSTM1 and theta class GSTT1. Isoenzymes encoded by these genes catalyse the de... Read More about Polymorphism in glutathione S-transferase loci as a risk factor for common cancers..

Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich (1998)
Journal Article
Matthias, C., Bockmühl, U., Jahnke, V., Petersen, I., Dietel, M., Fryer, A., & Strange, R. (1998). Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich. Laryngo-Rhino-Otologie, 77(4), 201-206. https://doi.org/10.1055/s-2007-996961

Background: While cigarette smoking and chronic alcohol consumption are the major risk factors for the development of head and neck cancer, it is assumed that genetic factors contribute to risk. Material and methods: We examined genotype frequencies... Read More about Influence of polymorphisms at glutathione-S-transferase gene loci on allelic losses in head and neck squamous cell carcinomas,Einfluss yon genpolymorphismen in den entgiftenden enzymen der glutathion-S-transferasen auf die chromosomale stabilitat yon plattenepithelkarzinomen im kopf-hals-bereich.

Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. (1997)
Journal Article
Lear, J. T., Tan, B. B., Smith, A. G., Bowers, W., Jones, P. W., Heagerty, A. H., …Fryer, A. A. (1997). Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. Journal of the Royal Society of Medicine, 90(7), https://doi.org/10.1177/014107689709000704

Basal cell carcinoma (BCC) is the commonest malignant neoplasm in white people. We present a large UK case-control study in which conditional logistic regression analysis of age-matched and gender-matched data sets was used to compare, first, cases w... Read More about Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients..