A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence
(2017)
Journal Article
Skidmore, M., Mohd Fadzli Mustaffa, K., Cooper, L. C., Guimond, S. E., Yates, E. A., & Craig, A. G. (2017). A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence. PloS one, 12(10), Article e0186276. https://doi.org/10.1371/journal.pone.0186276
A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the parasite-derived surface protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).... Read More about A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence.