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All Outputs (151)

Addressing the inequity of access to home Dialysis in Europe: recommendations for action informed by an international consensus exercise (2025)
Journal Article
Davies, S. J., Bammens, B., de Barbieri, I., Brown, E. A., van Cruchten, J., Gallego, D., Goffin, E., Gallieni, M., Gliki, S., Kooman, J. P., Meeus, G., Moeslund-Hansen, M.-B., Rutherford, P., Vanholder, R., Wilkie, M., & Van Biesen, W. (2025). Addressing the inequity of access to home Dialysis in Europe: recommendations for action informed by an international consensus exercise. BMC Nephrology, 26(1), 1-10. https://doi.org/10.1186/s12882-025-04188-y

Background: Use of Home Dialysis (referring to both peritoneal and home haemodialysis throughout this study), is under-exploited and highly variable across Europe, and this is the case both within as well as between countries. Several, predominantly... Read More about Addressing the inequity of access to home Dialysis in Europe: recommendations for action informed by an international consensus exercise.

The Cost-Effectiveness of Initiating Patients on Home Dialysis Compared with In-Centre Haemodialysis (2025)
Journal Article
Hill, H., Fotheringham, J., Potts, J., Solis-Trapala, I., Lambie, M., Damery, S., Allen, K., Wailoo, A., Williams, I., & Davies, S. (2025). The Cost-Effectiveness of Initiating Patients on Home Dialysis Compared with In-Centre Haemodialysis. Applied Health Economics and Health Policy, https://doi.org/10.1007/s40258-025-00976-7

Objectives
Kidney failure can be treated at home with peritoneal dialysis or home haemodialysis. The combination of reduced staffing, transport and overhead costs and improved quality of life through treatment at home could make initiating dialysis... Read More about The Cost-Effectiveness of Initiating Patients on Home Dialysis Compared with In-Centre Haemodialysis.

Volume Assessment in Patients Undergoing Long-Term Dialysis (2025)
Journal Article
Lazarus, B., Davies, S. J., & Polkinghorne, K. R. (2025). Volume Assessment in Patients Undergoing Long-Term Dialysis. Journal of the American Society of Nephrology, 36(6), 1184-1196. https://doi.org/10.1681/asn.0000000724

Accurate assessment of fluid status is a priority for patients with kidney failure undergoing long-term dialysis. There is wide variation in current volume-related practices between dialysis units and an urgent need to develop better evidence to guid... Read More about Volume Assessment in Patients Undergoing Long-Term Dialysis.

International Home Dialysis Consortium: Declaration Advocating for the Promotion of Home Dialysis Globally (2025)
Journal Article
Brown, E. A., Jha, V., Bavanandan, S., Chan, C. T., Davies, S., Figueirido, A., Liew, A., Madero, M., Niang, A., Mehrotra, R., Mitra, S., Rutherford, P., Saxena, A., Schiller, B., Schmitt, C. P., Tang, S. C., & Tchokhonelidze, I. (2025). International Home Dialysis Consortium: Declaration Advocating for the Promotion of Home Dialysis Globally. Kidney International Reports, https://doi.org/10.1016/j.ekir.2025.03.012

The clinical implications and cost-effectiveness of the provision of medical in addition to surgical catheter insertion for peritoneal dialysis in people with kidney failure (2025)
Journal Article
Hill, H., Rawdin, A., Wailoo, A., Briggs, V., Lambie, M., McCullough, K., Dunn, L., Davies, S., Wilkie, M., & Fotheringham, J. (in press). The clinical implications and cost-effectiveness of the provision of medical in addition to surgical catheter insertion for peritoneal dialysis in people with kidney failure. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608251314976

Background High-quality and timely peritoneal access is essential for effective peritoneal dialysis (PD). Existing comparisons of medical compared to surgical catheter insertion have focused on the incidence of catheter events, but the cost-effective... Read More about The clinical implications and cost-effectiveness of the provision of medical in addition to surgical catheter insertion for peritoneal dialysis in people with kidney failure.

Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial (2025)
Journal Article
Coyle, D., Ormandy, P., Fernandes da Silva, N., & Davies, S. J. (in press). Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial. Health Technology Assessment, 1-18. https://doi.org/10.3310/DOTR5903

For people receiving haemodialysis, a balance has to be struck between removing sufficient but not too much fluid during a treatment session and maintaining any remaining kidney function they might have. In the BISTRO trial, this study sought to esta... Read More about Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial.

How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England (2024)
Journal Article
Allen, K., Shaw, K. L., Spry, J. L., Dikomitis, L., Coyle, D., Damery, S., Fotheringham, J., Lambie, M., Williams, I. P., & Davies, S. (2024). How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England. BMJ Open, 14(12), https://doi.org/10.1136/bmjopen-2024-085754

Objective: The proportion of people having home dialysis for kidney disease varies considerably by treating centre, socioeconomic deprivation levels in the area and to some extent ethnicity. This study aimed to gain in-depth insights into cultural an... Read More about How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England.

The International Society of Nephrology Collaborative Quality Framework to Support Safe and Effective Dialysis Provision in Resource-Challenged Settings. (2024)
Journal Article
Davies, S., Naicker, S., Liew, A., Vachharajani, T., Pecoits-Filho, R., Jha, V., Finkelstein, F., & Harris, D. C. (2024). The International Society of Nephrology Collaborative Quality Framework to Support Safe and Effective Dialysis Provision in Resource-Challenged Settings. Kidney International Reports, 10(3), 663-672. https://doi.org/10.1016/j.ekir.2024.11.1366

Global underprovision of affordable dialysis results in inequitable access to safe and effective treatment. The need for a dialysis quality framework that would set minimum standards for safe and effective treatment, was identified as a key priority... Read More about The International Society of Nephrology Collaborative Quality Framework to Support Safe and Effective Dialysis Provision in Resource-Challenged Settings..

The future of peritoneal dialysis (2024)
Presentation / Conference Contribution
Davies, S. The future of peritoneal dialysis. Presented at European Renal Association Congress, Stockholm

Peritoneal dialysis (PD), long established as the leading form of home dialysis, has comparatively good 5-year outcomes and cost-utility analyses have consistently demonstrated benefits to both patients and payers. Future improvements should still be... Read More about The future of peritoneal dialysis.

Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report (2024)
Journal Article
Elphick, E. H., Manera, K. E., Viecelli, A. K., Craig, J. C., Cho, Y., Ju, A., Shen, J. I., Wilkie, M., Anumudu, S., Boudville, N., Chow, J. S., Davies, S. J., Gooden, P., Harris, T., Jain, A. K., Liew, A., Matus-Gonzalez, A., Amir, N., Nadeau-Fredette, A.-C., Nguyen, T., …Lambie, M. (in press). Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241287684

Background Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically important outcome... Read More about Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report.

Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients (2024)
Journal Article
Johal, N., Sharma, R., Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients. BMC Nephrology, 25(1), Article 398. https://doi.org/10.1186/s12882-024-03837-y

Introduction: Fluid assessment and management is a key aspect of good dialysis care and is affected by patient-level characteristics and potentially centre-level practices. In this secondary analysis of the BISTRO trial we wished to establish whether... Read More about Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients.

Dynamic Prediction of Cardiovascular Events in Incident Patients on Peritoneal Dialysis with Multivariate Joint Models Adjusting for Phosphate, Albumin, and Calcium Trajectories and Competing Risks (2024)
Presentation / Conference
Damgov, I., Kieser, M., Davies, S. J., Wong, M. G., Pollock, C. A., Johnson, D. W., & Schmitt, C. P. (2024, October). Dynamic Prediction of Cardiovascular Events in Incident Patients on Peritoneal Dialysis with Multivariate Joint Models Adjusting for Phosphate, Albumin, and Calcium Trajectories and Competing Risks. Poster presented at Kidney Week, San Diego, CA

Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial. (2024)
Journal Article
Worthington, J., Soundy, A., Frost, J., Rooshenas, L., MacNeill, S. J., Realpe Rojas, A., Garfield, K., Liu, Y., Alloway, K., Ben-Shlomo, Y., Burns, A., Chilcot, J., Darling, J., Davies, S., Farrington, K., Gibson, A., Husbands, S., Huxtable, R., McNally, H., Murphy, E., …Caskey, F. J. (2024). Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial. Trials, 25(1), 1-19. https://doi.org/10.1186/s13063-024-08509-8

Background: Chronic kidney disease (CKD) prevalence is steadily increasing, in part due to increased multimorbidity in our aging global population. When progression to kidney failure cannot be avoided, people need unbiased information to inform decis... Read More about Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial..

Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial (2024)
Journal Article
Belcher, J., Coyle, D., Lindley, E. J., Keane, D., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J., Hugo Macdonald, J., Solis-Trapala, I., Sim, J., & Davies, S. J. (2024). Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial. Kidney360, https://doi.org/10.34067/kid.0000000596

Preservation of residual kidney function (RKF) in dialysis patients has been associated with improved survival. RKF in the BISTRO trial was relatively well preserved and here we describe its association with survival during the trial and extended fol... Read More about Impact of the Preservation of Residual Kidney Function on Hemodialysis Survival: Results from the BISTRO Trial.

Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT (2024)
Journal Article
Zanganeh, M., Belcher, J., Fotheringham, J., Coyle, D., Lindley, E. J., Keane, D. F., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., Macdonald, J. H., Solis-Trapala, I., Sim, J., Davies, S. J., & Andronis, L. (2024). Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT. Health Technology Assessment, 1-45. https://doi.org/10.3310/jypr4287

Background
The BioImpedance Spectroscopy to maintain Renal Output randomised controlled trial investigated the effect of bioimpedance spectroscopy added to a standardised fluid management protocol on the risk of anuria and preservation of residual k... Read More about Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT.

Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis. (2024)
Journal Article
Bonomini, M., Davies, S., Kleophas, W., Lambie, M., Reboldi, G., Liberato, L. D., Divino-Filho, J. C., Heimburger, O., Ortiz, A., Povlsen, J., Iacobelli, M., Prosdocimi, T., & Arduini, A. (2024). Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241274106

Peritoneal dialysis adoption and technique survival is affected by limitations related to peritoneal membrane longevity and metabolic alterations. Indeed, almost all peritoneal dialysis fluids exploit glucose as an osmotic agent that rapidly diffuses... Read More about Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis..

Impact of Chronic Kidney Disease on the Processes of Care and Long-Term Mortality of Non-ST-Segment-Elevation Myocardial Infarction: A Nationwide Cohort Study and Long-Term Follow-Up. (2024)
Journal Article
Weight, N., Moledina, S., Ullah, M., Wijeysundera, H. C., Davies, S., Chew, N. W. S., Lawson, C., Khan, S. U., Gale, C. P., Rashid, M., & Mamas, M. A. (in press). Impact of Chronic Kidney Disease on the Processes of Care and Long-Term Mortality of Non-ST-Segment-Elevation Myocardial Infarction: A Nationwide Cohort Study and Long-Term Follow-Up. Journal of the American Heart Association, 13(16), Article e032671. https://doi.org/10.1161/JAHA.123.032671

A growing population of patients with chronic kidney disease (CKD) presents with non-ST-segment-elevation myocardial infarction, although little is known about their longer-term mortality. Using the MINAP (Myocardial Ischaemia National Audit Project)... Read More about Impact of Chronic Kidney Disease on the Processes of Care and Long-Term Mortality of Non-ST-Segment-Elevation Myocardial Infarction: A Nationwide Cohort Study and Long-Term Follow-Up..

#2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank (2024)
Presentation / Conference
Tabinor, M., Potts, J., Ferro, C. J., Davies, S., & Solis-Trapala, I. (2024, May). #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank. Presented at 61st ERA Congress, Stockholm, Sweden

Background and Aims There is data suggesting estimated glomerular filtration rate using Cystatin-C (eGFRCystatin-C) is superior to the creatinine-based (eGFRCreat) method when assessing associations between renal function and mortality (Lees et al. 2... Read More about #2796 Divergent associations between mortality and different measures of renal function after adjustment for body composition: results from the UK Biobank.