'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics

Jenkins, S; Weinberg, D; Al-Shakli, A; Fernandes, A; Yiu, HHP; Telling, N; Roach, P; Chari, D

doi:10.1016/j.jconrel.2016.01.013

All Outputs (3)

Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake (2016)
Journal Article
Weightman, A. P., Jenkins, S. I., & Chari, D. M. (2016). Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake. Nano Research, 9(8), 2384-2397. https://doi.org/10.1007/s12274-016-1125-7

Development of nanoparticle (NP) based therapies to promote regeneration in sites of central nervous system (CNS; i.e. brain and spinal cord) pathology relies critically on the availability of experimental models that offer biologically valid predict... Read More about Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake.

Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance. (2016)
Journal Article
Tickle, J., Jenkins, S., Polyak, B., Pickard, M., & Chari, D. (2016). Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance. Nanomedicine, 345 - 358. https://doi.org/10.2217/nnm.15.202

AIM: To achieve high and sustained magnetic particle loading in a proliferative and endocytotically active neural transplant population (astrocytes) through tailored magnetite content in polymeric iron oxide particles. MATERIALS & METHODS: MPs of var... Read More about Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance..

'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics (2016)
Journal Article
Jenkins, S., Weinberg, D., Al-Shakli, A., Fernandes, A., Yiu, H., Telling, N., …Chari, D. (2016). 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics. Journal of Controlled Release, 224, 136-145. https://doi.org/10.1016/j.jconrel.2016.01.013

Surface engineering to control cell behavior is of high interest across the chemical engineering, drug delivery and biomaterial communities. Defined chemical strategies are necessary to tailor nanoscale protein interactions/adsorption, enabling contr... Read More about 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics.