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All Outputs (328)

Defining acute flares in knee osteoarthritis: A systematic review (2018)
Journal Article
Thomas, M., Peat, G., & Parry, E. (2018). Defining acute flares in knee osteoarthritis: A systematic review. BMJ Open, 8(7), Article e019804. https://doi.org/10.1136/bmjopen-2017-019804

OBJECTIVE: To identify and critically synthesise definitions of acute flares in knee osteoarthritis (OA) reported in the medical literature. DESIGN: Systematic review and narrative synthesis. We searched Medline, EMBASE, Web of science and six other... Read More about Defining acute flares in knee osteoarthritis: A systematic review.

Expressed information needs of patients with osteoporosis and/or fragility fractures: a systematic review (2018)
Journal Article
Jordan, Babatunde, & Paskins. (2018). Expressed information needs of patients with osteoporosis and/or fragility fractures: a systematic review. Archives of Osteoporosis, 13(55), https://doi.org/10.1007/s11657-018-0470-4

This systematic review identified patients have unmet information needs about the nature of osteoporosis, medication, self-management and follow-up. Clinician knowledge and attitudes appear to be of key importance in determining whether these needs a... Read More about Expressed information needs of patients with osteoporosis and/or fragility fractures: a systematic review.

Erratum to pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis (2018)
Journal Article
Solo, K., Lavi, S., Choudhury, T., Martin, J., Nevis, I. F., Kwok, C. S., …Bagur, R. (2018). Erratum to pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis. Journal of thoracic disease, 10(12), E860-E860. https://doi.org/10.21037/jtd.2018.10.120

Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis

In the article that appeared on Page 3444-3459, Vol 10, No 6 (June 2018) Issue of the Journal of Thoracic Disease (J... Read More about Erratum to pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis.

Prevalence of foot pain across an international consortium of population based cohorts. (2018)
Journal Article
Gates, L. S., Arden, N. K., Hannan, M. T., Roddy, E., Gill, T. K., Hill, C. L., …Golightly, Y. M. (2019). Prevalence of foot pain across an international consortium of population based cohorts. Arthritis Care and Research, 71(5), 661-670. https://doi.org/10.1002/acr.23829

OBJECTIVE:
Despite the potential burden of foot pain, some of the most fundamental epidemiological questions surrounding the foot remain poorly explored. The prevalence of foot pain has proved difficult to compare across existing studies due to var... Read More about Prevalence of foot pain across an international consortium of population based cohorts..

Can the STarT Back Tool predict health-related quality of life and work ability after an acute/subacute episode with back or neck pain? A psychometric validation study in primary care. (2018)
Journal Article
Hill, J. (2018). Can the STarT Back Tool predict health-related quality of life and work ability after an acute/subacute episode with back or neck pain? A psychometric validation study in primary care. BMJ Open, https://doi.org/10.1136/bmjopen-2018-021748

OBJECTIVES: The predictive ability of the STarT Back Tool (SBT) has not yet been examined among acute/subacute back and/or neck pain in a primary care setting in respect to health-related quality of life (HRQoL) and work ability outcomes. The aim of... Read More about Can the STarT Back Tool predict health-related quality of life and work ability after an acute/subacute episode with back or neck pain? A psychometric validation study in primary care..

Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs (2018)
Journal Article
Yeates, P., Cope, N., Hawarden, A., Bradshaw, H., McCray, G., & Homer, M. (2019). Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs. Medical Education, 53(3), 250-263. https://doi.org/10.1111/medu.13783

Background:
Whilst averaging across multiple examiners judgements reduces unwanted overall score variability in Objective Structured Clinical Examinations (OSCE), designs involving several parallel circuits of the OSCE require that different examin... Read More about Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs.

Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial (2018)
Journal Article
Sim, J., Grocott, N., Majeed, H., & McClelland, D. (2019). Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial. Journal of Foot and Ankle Surgery, 58(1), 114-118. https://doi.org/10.1053/j.jfas.2018.08.023

Approximately 50% of ankle fractures require internal fixation. A tourniquet is often employed to create a bloodless operative field, but its effect on hospital length of stay (LOS) is unclear. This paper reports a parallel-group observer-blinded ran... Read More about Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial.

HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis (2018)
Journal Article
Dand, N., Duckworth, M., Baudry, D., Russell, A., Curtis, C. J., Hyuck Lee, S., …Study Group, B. (2019). HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. Journal of Allergy and Clinical Immunology, 143(6), 2120-2130. https://doi.org/10.1016/j.jaci.2018.11.038

BACKGROUND: Biologic therapies can be highly effective for the treatment of severe psoriasis, but response for individual patients can vary according to drug. Predictive biomarkers to guide treatment selection could improve patient outcomes and treat... Read More about HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis.

Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease (2018)
Journal Article
Mamas. (2018). Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease. Journal of the American Medical Association, https://doi.org/10.1001/jamanetworkopen.2018.5489

IMPORTANCE
In heart failure (HF), chronic obstructive pulmonary disease (COPD) increases the risk of poor outcomes, but the effect of COPD severity is unknown. This information is important for early intervention tailored to the highest-risk groups.... Read More about Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease.

The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners (2018)
Journal Article
Chew-Graham, C., Shepherd, T., Burroughs, H., Dixon, K., & Kessler, D. (2018). The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners. BMC Family Practice, https://doi.org/10.1186/s12875-018-0877-4

BACKGROUND: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. The number of prescriptions for antidepressants has risen dramatically in recent years yet up to 50% of patients... Read More about The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners.

Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. (2018)
Journal Article
(2018). Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology, 825 - 836. https://doi.org/10.1016/S2468-1253%2818%2930301-7

BACKGROUND: In patients with rectal cancer who achieve clinical complete response after neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with potential to avoid major surgery. Study-level meta-analyses have reported wide v... Read More about Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis..

Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA) (2018)
Journal Article
Šoltić, D., Bowerman, M., Stock, J., Shorrock, H. K., Gillingwater, T. H., & Fuller, H. R. (2018). Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA). Brain Sciences, https://doi.org/10.3390/brainsci8120212

Unravelling the complex molecular pathways responsible for motor neuron degeneration in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) remains a persistent challenge. Interest is growing in the potential molecular similarities... Read More about Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA).

Development and validation of a clinical rule for recognition of early inflammatory arthritis (2018)
Journal Article
Mallen, C., & Hider, S. (2018). Development and validation of a clinical rule for recognition of early inflammatory arthritis. BMJ Open, https://doi.org/10.1136/bmjopen-2018-023552

Objectives
National and international guidelines recommend prompt referral of patients presenting with inflammatory arthritis (IA), but general practitioners (GPs) feel uncertain in their proficiency to detect synovitis through joint examination, th... Read More about Development and validation of a clinical rule for recognition of early inflammatory arthritis.

Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017 (2018)
Journal Article
Muller, S., O'Brien, A., Helliwell, T., Hay, C. A., Gilbert, K., Mallen, C. D., & Busby, K. (2018). Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017. Clinical Rheumatology, 3411-3418. https://doi.org/10.1007/s10067-018-4220-1

Polymyalgia rheumatica and giant cell arteritis are relatively common, but under research inflammatory rheumatological conditions. This survey aimed to ascertain the matters in which patients feel they need support with these conditions and appraise... Read More about Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017.

Prognostic indicators of outcome for patients with skeletal metastases from carcinoma of the prostate (2018)
Journal Article
Shepherd, K. L., Cool, P., & Cribb, G. (2018). Prognostic indicators of outcome for patients with skeletal metastases from carcinoma of the prostate. The Bone & Joint Journal, 100B(12), 1647-1654. https://doi.org/10.1302/0301-620X.100B12.BJJ-2018-0697.R1

Aims
The purpose of this study was to identify prognostic indicators of outcome at presentation to the orthopaedic surgeon, in patients with metastatic prostate cancer. Our aim was to use this information in a pragmatic, clinic-based approach so tha... Read More about Prognostic indicators of outcome for patients with skeletal metastases from carcinoma of the prostate.

Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care (2018)
Journal Article
Mallen, Roddy, & Muller. (2018). Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care. Arthritis Care and Research, 1822-1828. https://doi.org/10.1002/acr.23562

Objective
To examine the association between gout severity and socioeconomic status (SES) and gout severity and work absence.

Methods
Postal questionnaires were sent to adult patients who were registered with 20 general practices and who had co... Read More about Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care.

Comparatively salient: examining the influence of preceding performances on assessors' focus and interpretations in written assessment comments. (2018)
Journal Article
Yeates. (2018). Comparatively salient: examining the influence of preceding performances on assessors' focus and interpretations in written assessment comments. Advances in Health Sciences Education, 937-959. https://doi.org/10.1007/s10459-018-9841-2

Recent literature places more emphasis on assessment comments rather than relying solely on scores. Both are variable, however, emanating from assessment judgements. One established source of variability is "contrast effects": scores are shifted away... Read More about Comparatively salient: examining the influence of preceding performances on assessors' focus and interpretations in written assessment comments..

Agreement between subjective and objective measures of sleep duration in a low-middle income country setting. (2018)
Journal Article
(2018). Agreement between subjective and objective measures of sleep duration in a low-middle income country setting. Sleep Health, 543 - 550. https://doi.org/10.1016/j.sleh.2018.08.008

OBJECTIVES: Describe sleep duration in adult Sri Lankans and determine the bias and agreement of self-report and actigraphic assessments. DESIGN: Validation sub-study nested within the Colombo Twin and Singleton Study (2012-2015). SETTING: Colombo, S... Read More about Agreement between subjective and objective measures of sleep duration in a low-middle income country setting..