All Outputs (625)

Which behaviour change techniques are associated with interventions that increase physical activity in pre-school children? A systematic review (2023)
Journal Article
Al-walah, M. A., Donnelly, M., Cunningham, C., & Heron, N. (in press). Which behaviour change techniques are associated with interventions that increase physical activity in pre-school children? A systematic review. BMC Public Health, 23(1), 2013. https://doi.org/10.1186/s12889-023-16885-0

Background: Insufficient physical activity (PA) is a significant risk factor that contributes to several health problems and there is a need to improve our understanding of how to increase PA, particularly among young children. This review (PROSPERO... Read More about Which behaviour change techniques are associated with interventions that increase physical activity in pre-school children? A systematic review.

Hospital-presenting self-harm among older adults living in Ireland: a 13-year trend analysis from the National Self-Harm Registry Ireland. (2023)
Journal Article
Isabela Troya, M., Griffin, E., Arensman, E., Cassidy, E., Mughal, F., Lonergan, C. N., …Corcoran, P. (2023). Hospital-presenting self-harm among older adults living in Ireland: a 13-year trend analysis from the National Self-Harm Registry Ireland. International Psychogeriatrics, 1-9. https://doi.org/10.1017/S1041610223000856

To examine trends in rates of self-harm among emergency department (ED) presenting older adults in Ireland over a 13-year period. Population-based study using data from the National Self-Harm Registry Ireland. National hospital EDs. Older adults aged... Read More about Hospital-presenting self-harm among older adults living in Ireland: a 13-year trend analysis from the National Self-Harm Registry Ireland..

Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis. (2023)
Journal Article
Najim, M., Reda Mostafa, M., Eid, M. M., Alabdouh, A., Awad, A. K., Elbanna, M., …Mamas, M. A. (in press). Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis. American Journal of Cardiovascular Disease, 13(5), 291-299

The first-generation Watchman 2.5 (W 2.5) presented several limitations, such as challenges in implantation within complex left atrial appendage (LAA) anatomies, higher incidence of peri-device leak, device recapture, and device-related thrombus (DR... Read More about Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis..

Social Vulnerability and Hemopericardial Cardiovascular Death: Insight from the Centers for Disease Control and Prevention Databases (2023)
Journal Article
Sainbayar, E., Ibrahim, R., Pham, H. N., Beauti, W., Shahid, M., Hickerson, N., …Mamas, M. A. (in press). Social Vulnerability and Hemopericardial Cardiovascular Death: Insight from the Centers for Disease Control and Prevention Databases. The American Journal of Cardiology, 210, 143-145. https://doi.org/10.1016/j.amjcard.2023.10.029

Association Between Cardiologist Density and Mortality in Urban and Rural Counties in the United States. (2023)
Journal Article
Minhas, A. M. K., Cullen, M. W., Mamas, M. A., Fudim, M., Virani, S. S., Khan, S. S., …Abramov, D. (in press). Association Between Cardiologist Density and Mortality in Urban and Rural Counties in the United States. The American Journal of Cardiology, S0002-9149(23)01162-1. https://doi.org/10.1016/j.amjcard.2023.10.024

A scoping review of patient self-report measures of flare in knee and hip osteoarthritis (OA): A report from the OMERACT flares in OA working group (2023)
Journal Article
Queiroga, F., Cross, M., Thomas, M. J., March, L., Epstein, J., & Guillemin, F. (2023). A scoping review of patient self-report measures of flare in knee and hip osteoarthritis (OA): A report from the OMERACT flares in OA working group. Seminars in Arthritis and Rheumatism, 63, Article 152281. https://doi.org/10.1016/j.semarthrit.2023.152281

Purpose
We aimed to analyze the content validity/domain match and feasibility of self-report instruments that could measure flare in osteoarthritis (OA), by extending our 2017 literature review on the definition of flare in knee and hip OA.

Metho... Read More about A scoping review of patient self-report measures of flare in knee and hip osteoarthritis (OA): A report from the OMERACT flares in OA working group.

Longer-term quality of care, effectiveness, and cost-effectiveness of implementing a model of care for osteoarthritis: a cluster-randomized controlled trial (2023)
Journal Article
Østerås, N., Aas, E., Moseng, T., van Bodegom-Vos, L., Dziedzic, K., Natvig, B., …Hagen, K. B. (2024). Longer-term quality of care, effectiveness, and cost-effectiveness of implementing a model of care for osteoarthritis: a cluster-randomized controlled trial. Osteoarthritis and Cartilage, 32(1), 108-119. https://doi.org/10.1016/j.joca.2023.10.003

Objective
To assess the quality of care, effectiveness, and cost-effectiveness over 12 months after implementing a structured model of care for hip and knee osteoarthritis in primary healthcare as compared to usual care.

Design
In this pragmatic... Read More about Longer-term quality of care, effectiveness, and cost-effectiveness of implementing a model of care for osteoarthritis: a cluster-randomized controlled trial.

Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink (2023)
Journal Article
Scott, I. C., Jordan, K. P., Twohig, H., Whittle, R., Muller, S., Hider, S. L., …Bailey, J. (2023). Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink. Rheumatology, Article kead463. https://doi.org/10.1093/rheumatology/kead463

Despite little evidence that analgesics are effective in inflammatory arthritis (IA), studies report substantial opioid prescribing. The extent this applies to other analgesics is uncertain. We undertook a comprehensive evaluation of analgesic prescr... Read More about Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink.

Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis (2023)
Journal Article
Papoutsis, D., Underwood, M., Parry-Smith, W., & Tzavara, C. (2024). Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, 309, 939–948. https://doi.org/10.1007/s00404-023-07242-y

Background
There is a growing body of evidence suggesting that endocervical crypt involvement by high-grade cervical intraepithelial neoplasia (CIN) may represent a risk factor for disease recurrence after cervical treatment.

Objectives
To provi... Read More about Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis.

Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial (2023)
Presentation / Conference
Roffe, C., Warusevitane, A., Smith, C., Dixit, A., Sprigg, N., Ogollah, R., …Bath, P. (2023, October). Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial. Poster presented at 15th World Stroke Congress, Toronto, Canada

The research study is designed to assess a treatment which might prevent pneumonia and improve survival in patients that have had a stroke.
Pneumonia is a major cause of death after stroke and delays recovery in survivors. The most important cause o... Read More about Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial.

Diagnostic clinical prediction rules for categorising low back pain: A systematic review (2023)
Journal Article
Hill, C. J., Banerjee, A., Hill, J., & Stapleton, C. (in press). Diagnostic clinical prediction rules for categorising low back pain: A systematic review. Musculoskeletal Care, https://doi.org/10.1002/msc.1816

Background: Low back pain (LBP) is a common complex condition, where specific diagnoses are hard to identify. Diagnostic clinical prediction rules (CPRs) are known to improve clinical decision‐making. A review of LBP diagnostic‐CPRs by Haskins et al.... Read More about Diagnostic clinical prediction rules for categorising low back pain: A systematic review.

Recognising and managing osteoarthritis flares in primary care. (2023)
Journal Article
Parry, E., Walker, C., & Thomas, M. J. (in press). Recognising and managing osteoarthritis flares in primary care. BMJ, 383, Article e076455. https://doi.org/10.1136/bmj-2023-076455

Impact of Body Mass Index on outcomes in hospitalized heart failure patients with reduced versus preserved ejection fraction: a 1,699,494-individual analysis from the United States National Inpatient Sample. (2023)
Journal Article
Ansari, S. A., Suheb, M. Z., Rashid, M., Maqsood, M. H., Rashid, A. M., Javaid, S. S., & Siddiqi, A. K. (in press). Impact of Body Mass Index on outcomes in hospitalized heart failure patients with reduced versus preserved ejection fraction: a 1,699,494-individual analysis from the United States National Inpatient Sample. Minerva Cardiology and Angiology, https://doi.org/10.23736/S2724-5683.23.06367-6

Obesity's effect on outcomes in heart failure (HF) patients with reduced versus maintained ejection fraction (HFrEF and HFpEF) remains debatable. We evaluated hospital outcomes and healthcare expenditures in these patients based on their Body Mass In... Read More about Impact of Body Mass Index on outcomes in hospitalized heart failure patients with reduced versus preserved ejection fraction: a 1,699,494-individual analysis from the United States National Inpatient Sample..

Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery (2023)
Journal Article
Etherington, C., Boet, S., Chen, I., Duffy, M., Mamas, M. A., Eddeen, A. B., …Sun, L. Y. (in press). Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery. Annals of Surgery, 279(4), 563-568. https://doi.org/10.1097/sla.0000000000006111

Objective:
To investigate the association between surgeon-anesthesiologist sex discordance and patient mortality after noncardiac surgery.

Background:
Evidence suggests different practice patterns exist among female and male physicians. Howeve... Read More about Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery.

An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides (2023)
Journal Article
Selvakumaran, J., Ursu, S., Bowerman, M., Lu-Nguyen, N., Wood, M. J., Malerba, A., & Yáñez-Muñoz, R. J. (2023). An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides. Biomedicines, 11(10), Article 2700. https://doi.org/10.3390/xxxxx

The blood-brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts to develop therapeutic agents targeting the CNS have been hindered by the lack of predictiv... Read More about An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides.

An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides (2023)
Journal Article
Selvakumaran, J., Ursu, S., Bowerman, M., Lu-Nguyen, N., Wood, M. J., Malerba, A., & Yáñez-Muñoz, R. J. (2023). An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides. Biomedicines, 11(10), Article 2700. https://doi.org/10.3390/biomedicines11102700

The blood–brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts to develop therapeutic agents targeting the CNS have been hindered by the lack of predictiv... Read More about An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides.

Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies (2023)
Journal Article
Wells, I., Simons, G., Kanacherril, J. P., Mallen, C. D., Raza, K., & Falahee, M. (in press). Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies. BMC Rheumatology, 7(1), Article 35. https://doi.org/10.1186/s41927-023-00361-8

Background: There is increasing research interest in the development of preventive treatment for individuals at risk of rheumatoid arthritis (RA). Previous studies have explored the perceptions of at-risk groups and patients about predictive and prev... Read More about Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies.

Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019 (2023)
Journal Article
Raisi-Estabragh, Z., Kobo, O., López-Fernández, T., Qadir, H. A., Chew, N. W., Wojakowski, W., …Mamas, M. A. (2023). Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200218. https://doi.org/10.1016/j.ijcrp.2023.200218

Background
Temporal trends of the impact of social determinants on cardiovascular outcomes of cancer patients has not been previously studied.

Objectives
This study examined social disparities in cardiovascular mortality of people... Read More about Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019.

Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy? (2023)
Journal Article
Ingleton, A., Raseta, M., Chung, R., Kow, K. J. H., Weddell, J., Nayak, S., …Roffe, C. (2023). Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?. Stroke and Vascular Neurology, https://doi.org/10.1136/svn-2022-002267

Background: Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy (MT). Most patients undergoing MT are also given thrombolysis. Antiplatelet agents are contraindicated within 24 hours of thrombolysis... Read More about Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?.

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors (2023)
Journal Article
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A. A., Peters, J. A., …Ye, R. D. (2023). The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180, S23-S144. https://doi.org/10.1111/bph.16177

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interacti... Read More about The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.