Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion

Vasques, ER; Cunha, JEM; Coelho, AMM; Sampietre, SN; Patzina, RA; Abdo, EE; Nader, HB; Tersariol, ILS; Andrade De Lima, M; Godoy, CMG; Rodrigues, Tiago; Chaib, Eleazar; D’Albuquerque, Luiz A.C.

doi:10.1371/journal.pone.0149630

All Outputs (5)

A Brazilian perspective for the use of bovine heparin in open heart surgery (2016)
Journal Article
Gomes, W. J., Leal, J. C., Braile, D. M., Guimaraes, J. A., Lopes, R. D., Lima, M. A., & Nader, H. B. (2016). A Brazilian perspective for the use of bovine heparin in open heart surgery. International Journal of Cardiology, 223, 611-612. https://doi.org/10.1016/j.ijcard.2016.08.033

19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy (2016)
Journal Article
Lima, M. A., Cavalheiro, R. P., Viana, G. M., Meneghetti, M. C., Rudd, T. R., Skidmore, M., …Yates, E. A. (2016). 19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconjugate Journal, 34, 405-410. https://doi.org/10.1007/s10719-016-9723-x

Studying polysaccharide-protein interactions under physiological conditions by conventional techniques is challenging. Ideally, macromolecules could be followed by both in vitro spectroscopy experiments as well as in tissues using microscopy, to enab... Read More about 19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy.

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils (2016)
Journal Article
Stewart, K. L., Hughes, E., Yates, E. A., Akien, G. R., Huang, T., Andrade De Lima, M., …Middleton, D. A. (2016). Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils. Journal of the American Chemical Society, 138(27), 8328-8331. https://doi.org/10.1021/jacs.6b02816

The amyloid plaques associated with Alzheimer’s disease (AD) comprise fibrillar amyloid-ß (Aß) peptides as well as non-protein factors including glycosaminoglycan (GAG) polysaccharides. GAGs affect the kinetics and pathway of Aß self-assembly and can... Read More about Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils.

Active site mapping of Loxosceles phospholipases D: Biochemical and biological features (2016)
Journal Article
Vuitika, L., Chaves-Moreira, D., Caruso, I., Lima, M. A., Matsubara, F. H., Murakami, M. T., …Veiga, S. S. (2016). Active site mapping of Loxosceles phospholipases D: Biochemical and biological features. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1861(9), 970-979. https://doi.org/10.1016/j.bbalip.2016.05.009

Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion (2016)
Journal Article
Vasques, E., Cunha, J., Coelho, A., Sampietre, S., Patzina, R., Abdo, E., …D’Albuquerque, L. A. (2016). Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion. PloS one, 11, e0149630--e0149630. https://doi.org/10.1371/journal.pone.0149630

Background
Ischemia and reperfusion (I/R) causes tissue damage and intracellular calcium levels are a factor of cell death. Sodium calcium exchanger (NCX) regulates calcium extrusion and Trisulfated Disaccharide (TD) acts on NCX decreasing intracell... Read More about Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion.