Skip to main content

Research Repository

Advanced Search

All Outputs (81)

Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma (2022)
Journal Article
Napolitano, V., Mróz, P., Marciniak, M., Kalel, V. C., Softley, C. A., Janna Olmos, J. D., …Dubin, G. (2022). Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma. European Journal of Medicinal Chemistry, 243, Article 114778. https://doi.org/10.1016/j.ejmech.2022.114778

Trypanosomiases are neglected tropical diseases caused by Trypanosoma (sub)species. Available treatments are limited and have considerable adverse effects and questionable efficacy in the chronic stage of the disease, urgently calling for the identif... Read More about Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.

Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds (2022)
Journal Article
Mogas Barcons, A., Chowdhury, F., Chari, D. M., & Adams, C. (2022). Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials, 16(1), Article 124. https://doi.org/10.3390/ma16010124

Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered constructs,... Read More about Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds.

Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific (2022)
Journal Article
Bojarinova, J., Kavokin, K., Cherbunin, R., Sannikov, D., Fedorishcheva, A., Pakhomov, A., & Chernetsov, N. (2023). Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific. Behavioral Ecology and Sociobiology, 77(1), https://doi.org/10.1007/s00265-022-03282-7

One of the most unusual features of the avian magnetic compass is its sensitivity to weak oscillating magnetic fields (OMF) in the radiofrequency range. This effect, observed earlier in numerous experiments in European robins Erithacus rubecula and g... Read More about Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific.

Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis (2022)
Journal Article
Ratto, F., Bruce, T., Chipabika, G., Mwamakamba, S., Mkandawire, R., Khan, Z., …Sait, S. (2022). Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis. Proceedings of the Royal Society B: Biological Sciences, https://doi.org/10.1098/rspb.2022.1695

Insect pests are a major challenge to smallholder crop production in sub-Saharan Africa (SSA), where access to synthetic pesticides, which are linked to environmental and health risks, is often limited. Biological control interventions could offer a... Read More about Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis.

Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes (2022)
Journal Article
Coon, K., Hegde, S., & Hughes, G. (2022). Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes. Microbiome, 10, Article 58. https://doi.org/10.1186/s40168-022-01256-5

Background Mosquitoes harbor microbial communities that play important roles in their growth, survival, reproduction, and ability to transmit human pathogens. Microbiome transplantation approaches are often used to study host-microbe interactions and... Read More about Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes.

Quantifying inherent predictability and spatial synchrony in the aphid vector Myzus persicae - field-scale patterns of abundance and regional forecasting error in the UK (2022)
Journal Article
Bell, J., Clark, S. J., Stevens, M., & Mead, A. (2023). Quantifying inherent predictability and spatial synchrony in the aphid vector Myzus persicae - field-scale patterns of abundance and regional forecasting error in the UK. Pest Management Science, 79(4), https://doi.org/10.1002/ps.7292

Background
Sugar beet is threatened by virus yellows, a disease complex vectored by aphids that reduces sugar content. We present an analysis of Myzus persicae population dynamics with and without neonicotinoid seed treatment. We use 6 years' yellow... Read More about Quantifying inherent predictability and spatial synchrony in the aphid vector Myzus persicae - field-scale patterns of abundance and regional forecasting error in the UK.

Biological Flora of Britain and Ireland: Viscum album (2022)
Journal Article
Thomas, P. A., Dering, M., Giertych, M. J., Iszkuło, G., Tomaszewski, D., & Briggs, J. (2022). Biological Flora of Britain and Ireland: Viscum album. Journal of Ecology, 111(3), 701-739. https://doi.org/10.1111/1365-2745.14036

This account presents information on all aspects of the biology of Viscum album L. (Mistletoe) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of the Biologi... Read More about Biological Flora of Britain and Ireland: Viscum album.

Silencing RNAs expressed from W-linked PxyMasc “retrocopies” target that gene during female sex determination in Plutella xylostella (2022)
Journal Article
Harvey-Samuel, T., Xu, X., Anderson, M. A. E., Carabajal Paladino, L. Z., Purusothaman, D., Norman, V. C., …Alphey, L. (2022). Silencing RNAs expressed from W-linked PxyMasc “retrocopies” target that gene during female sex determination in Plutella xylostella. Proceedings of the National Academy of Sciences of the United States of America, 119(46), https://doi.org/10.1073/pnas.2206025119

The Lepidoptera are an insect order of cultural, economic, and environmental importance, representing ∼10% of all described living species. Yet, for all but one of these species (silkmoth, Bombyx mori), the molecular genetics of how sexual fate is de... Read More about Silencing RNAs expressed from W-linked PxyMasc “retrocopies” target that gene during female sex determination in Plutella xylostella.

Demography of Common Swifts (Apus apus) breeding in the UK associated with local weather but not aphid biomass (2022)
Journal Article
Finch, T., Bell, J. R., Robinson, R. A., & Peach, W. J. (2023). Demography of Common Swifts (Apus apus) breeding in the UK associated with local weather but not aphid biomass. Ibis, 165(2), 420-435. https://doi.org/10.1111/ibi.13156

In common with many other insectivorous birds, the Common Swift Apus apus is undergoing population declines, with an estimated 57% reduction in abundance between 1995 and 2017 in the UK. The ultimate drivers of this decline are poorly understood but... Read More about Demography of Common Swifts (Apus apus) breeding in the UK associated with local weather but not aphid biomass.

Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review (2022)
Journal Article
Polidano, K., Wenning, B., Ruiz-Cadavid, A., Dawaishan, B., Panchal, J., Gunasekara, S., …Dikomitis, L. (2022). Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review. Social Sciences, 11(10), Article 490. https://doi.org/10.3390/socsci11100490

<jats:p>We reviewed the evidence on community-based interventions for the prevention and control of cutaneous leishmaniasis (CL). Community initiatives tailored towards awareness and mobilisation are regarded as a priority area in the Neglected Tropi... Read More about Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review.

Building a brighter future for Africa with the African Light Source. (2022)
Journal Article
(2022). Building a brighter future for Africa with the African Light Source. Nature Reviews Physics, 1 - 2. https://doi.org/10.1038/s42254-022-00534-3

Africa is the only habitable continent that is not yet host to a light source - an important tool across disciplines. Scientists from the Executive Committee of the African Light Source Foundation discuss work towards building an advanced light sourc... Read More about Building a brighter future for Africa with the African Light Source..

High resolution species assignment of Anopheles mosquitoes using k-mer distances on targeted sequences. (2022)
Journal Article
Boddé, M., Makunin, A., Ayala, D., Bouafou, L., Diabaté, A., Ekpo, U. F., …Lawniczak, M. K. (2022). High resolution species assignment of Anopheles mosquitoes using k-mer distances on targeted sequences. eLife, 11, Article e78775. https://doi.org/10.7554/elife.78775

The ANOSPP amplicon panel is a genus-wide targeted sequencing panel to facilitate large-scale monitoring of Anopheles species diversity. Combining information from the 62 nuclear amplicons present in the ANOSPP panel allows for a more senstive and sp... Read More about High resolution species assignment of Anopheles mosquitoes using k-mer distances on targeted sequences..

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence (2022)
Journal Article
Mallikarjun, V., Dobre, O., Jackson, M., Kidd, M., Llewellyn, J., Gilbert, H., …Swift, J. (2022). Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence. arXiv,

ABSTRACT Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche exp... Read More about Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence.

Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects (2022)
Journal Article
AlAbdi, L., Desbois, M., Rusnac, D., Sulaiman, R. A., Rosenfeld, J. A., Lalani, S., …Alkuraya, F. S. (2023). Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects. Brain, 146(4), https://doi.org/10.1093/brain/awac364

The corpus callosum is a bundle of axon fibres that connects the two hemispheres of the brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a core phenotype offer a valuable window into pathology derived from abnorma... Read More about Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects.

The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. (2022)
Journal Article
Fettiplace, R., Furness, D. N., & Beurg, M. (2022). The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. Proceedings of the National Academy of Sciences of the United States of America, 119(41), Article e2210849119. https://doi.org/10.1073/pnas.2210849119

Transmembrane channel-like protein 1 (TMC1) is thought to form the ion-conducting pore of the mechanoelectrical transducer (MET) channel in auditory hair cells. Using single-channel analysis and ionic permeability measurements, we characterized six m... Read More about The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells..

Increased outbreaks of monkeypox highlight gaps in actual disease burden in Sub-Saharan Africa and in animal reservoirs (2022)
Journal Article
Haider, N., Guitian, J., Simons, D., Asogun, D., Ansumana, R., Honeyborne, I., …Zumla, A. (2022). Increased outbreaks of monkeypox highlight gaps in actual disease burden in Sub-Saharan Africa and in animal reservoirs. International Journal of Infectious Diseases, 107 - 111. https://doi.org/10.1016/j.ijid.2022.05.058

We explain research gaps on Monkeypox (MPX) virus epidemiology in endemic countries and present hypotheses for the recent increase of MPX cases in West Africa as a possible explanation for the current epidemic in Europe, America, and Australia. The d... Read More about Increased outbreaks of monkeypox highlight gaps in actual disease burden in Sub-Saharan Africa and in animal reservoirs.

The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022 (2022)
Journal Article
Beard, P. (2022). The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022. Eurosurveillance, https://doi.org/10.2807/1560-7917.es.2022.27.39.2200758

<jats:p>We report results of surveillance between June and mid-September 2022 of pet animals living in households of confirmed human monkeypox (MPX) cases. Since surveillance commenced, 154 animals from 40 households with a confirmed human MPX case w... Read More about The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022.