All Outputs (156)

Arthroscopic Management of Femoroacetabular Impingement: Current Concepts (2025)
Journal Article
Migliorini, F., Pilone, M., Lucenti, L., Bardazzi, T., Pipino, G., Vaishya, R., & Maffulli, N. (in press). Arthroscopic Management of Femoroacetabular Impingement: Current Concepts. Journal of Clinical Medicine, 14(5), 1-35. https://doi.org/10.3390/jcm14051455

Background: Femoroacetabular impingement (FAI) is a common cause of hip pain and dysfunction, especially in young and active individuals, and it may require surgical management for associated labral tears and cartilage damage. The management of FAI h... Read More about Arthroscopic Management of Femoroacetabular Impingement: Current Concepts.

Arthroscopy for Femoroacetabular Impingement in Athletes Versus Non-Athletes: Systematic Review and Meta-Analysis (2025)
Journal Article
Migliorini, F., Maffulli, N., Bardazzi, T., Ramasubramanian, S., Jeyaraman, N., & Jeyaraman, M. (in press). Arthroscopy for Femoroacetabular Impingement in Athletes Versus Non-Athletes: Systematic Review and Meta-Analysis. Healthcare, 13(5), 1-13. https://doi.org/10.3390/healthcare13050470

Background: Femoroacetabular impingement (FAI) is a frequently observed hip condition among young, active individuals—especially athletes—that can result in pain, restricted mobility, and a heightened risk of osteoarthritis. Hip arthroscopy has incre... Read More about Arthroscopy for Femoroacetabular Impingement in Athletes Versus Non-Athletes: Systematic Review and Meta-Analysis.

Impact of education in patients undergoing physiotherapy for lower back pain: a level I systematic review and meta-analysis (2025)
Journal Article
Migliorini, F., Maffulli, N., Schäfer, L., Manocchio, N., Bossa, M., Foti, C., …Kubach, J. (in press). Impact of education in patients undergoing physiotherapy for lower back pain: a level I systematic review and meta-analysis. European Journal of Trauma and Emergency Surgery, 51(1), 1-19. https://doi.org/10.1007/s00068-025-02788-9

Introduction: Lower back pain (LBP) is one of the most common musculoskeletal disorders in modern society, with a lifetime incidence of up to 90%. According to most national and international guidelines, educational interventions play a central role... Read More about Impact of education in patients undergoing physiotherapy for lower back pain: a level I systematic review and meta-analysis.

Anterior Cruciate Ligament Reconstruction Using Lateral Extra-Articular Procedures: A Systematic Review (2025)
Journal Article
Migliorini, F., Lucenti, L., Mok, Y. R., Bardazzi, T., D’Ambrosi, R., De Carli, A., …Maffulli, N. (in press). Anterior Cruciate Ligament Reconstruction Using Lateral Extra-Articular Procedures: A Systematic Review. Medicina, 61(2), 1-18. https://doi.org/10.3390/medicina61020294

Background and Objectives: The present systematic review investigated the efficacy of lateral extra-articular tenodesis (LET) and anterolateral ligament (ALL) as lateral extra-articular procedures (LEAPs) for anterior cruciate ligament (ACL) reconstr... Read More about Anterior Cruciate Ligament Reconstruction Using Lateral Extra-Articular Procedures: A Systematic Review.

Plastic deformation of anterior cruciate ligament: listen to the patient, do not just rely on imaging (2025)
Journal Article
Piedade, S. R., Ferreira, D. M., Górios, C., & Maffulli, N. (in press). Plastic deformation of anterior cruciate ligament: listen to the patient, do not just rely on imaging. Journal of Orthopaedic Surgery and Research, 20(1), Article 144. https://doi.org/10.1186/s13018-025-05527-3

Purpose: Diagnosing plastic deformation of the anterior cruciate ligament (ACL) is challenging: patients may not report knee instability, and MRI may not confirm the lesion, delaying adequate treatment. This study analyzed clinical findings and compl... Read More about Plastic deformation of anterior cruciate ligament: listen to the patient, do not just rely on imaging.

Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence. (2025)
Journal Article
Gupta, A., Migliorini, F., Bardazzi, T., & Maffulli, N. (2025). Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence. Pain and Therapy, https://doi.org/10.1007/s40122-025-00707-9

Elbow ailments are common, but conventional treatment modalities have shortcomings, offering only interim pain relief rather than targeting the underlying pathophysiology. The last two decades have seen a marked increase in the use of autologous peri... Read More about Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence..

Minimal clinically important difference (MCID), patient-acceptable symptom state (PASS), and substantial clinical benefit (SCB) following surgical knee ligament reconstruction: a systematic review. (2025)
Journal Article
Migliorini, F., Maffulli, N., Jeyaraman, M., Schäfer, L., Rath, B., & Huber, T. (in press). Minimal clinically important difference (MCID), patient-acceptable symptom state (PASS), and substantial clinical benefit (SCB) following surgical knee ligament reconstruction: a systematic review. European Journal of Trauma and Emergency Surgery, 51(1), Article 32. https://doi.org/10.1007/s00068-024-02708-3

The minimal clinically important difference (MCID), patient-acceptable symptom state (PASS), and substantial clinical benefit (SCB) are designed to prioritise clinically significant outcomes that demonstrate true clinical benefit rather than relying... Read More about Minimal clinically important difference (MCID), patient-acceptable symptom state (PASS), and substantial clinical benefit (SCB) following surgical knee ligament reconstruction: a systematic review..

Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis (2025)
Journal Article
Migliorini, F., Maffulli, N., Nijboer, C. H., Pappalardo, G., Pasurka, M., Betsch, M., & Kubach, J. (in press). Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis. Biomedicines, 13(1), 1-21. https://doi.org/10.3390/biomedicines13010175

Background: The present Bayesian network meta-analysis compared the efficacy of intra-articular injections of different molecular weights of hyaluronic acid (HA) in patients with knee osteoarthritis. Methods: In November 2024, the following databases... Read More about Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis.

Augmentation with the inferior extensor retinaculum may facilitate earlier recovery in all-inside arthroscopic management of chronic lateral ankle instability (2025)
Journal Article
Luo, X., Xue, C., Xue, Y., Fehske, K., Zhang, Z.-H., Maffulli, N., …Feng, S.-M. (in press). Augmentation with the inferior extensor retinaculum may facilitate earlier recovery in all-inside arthroscopic management of chronic lateral ankle instability. Journal of Orthopaedic Surgery and Research, 20(1), 1-11. https://doi.org/10.1186/s13018-024-05437-w

Background: To compare the clinical outcomes of inferior extensor retinaculum (IER) augmentation following repair of the anterior talofibular ligament (ATFL) with isolated ATFL repair in patients with an arthroscopically confirmed grade 3 lesion of t... Read More about Augmentation with the inferior extensor retinaculum may facilitate earlier recovery in all-inside arthroscopic management of chronic lateral ankle instability.

Lewinnek zone not “the be-all and end-all” functional planning for acetabular component positioning in total hip arthroplasty (2025)
Journal Article
Iorio, R., Viglietta, E., Corsetti, F., Gugliotta, Y., Massafra, C., Polverari, D., …Maffulli, N. (in press). Lewinnek zone not “the be-all and end-all” functional planning for acetabular component positioning in total hip arthroplasty. Arthroplasty, 7(1), Article 2. https://doi.org/10.1186/s42836-024-00284-w

Background: Proper positioning of a total hip arthroplasty (THA) plays a crucial role in the success and long-term survivorship of the implant. Cup positioning within the Lewinnek Safe Zone (LSZ) does not, however, avoid implant dislocation. Thus, th... Read More about Lewinnek zone not “the be-all and end-all” functional planning for acetabular component positioning in total hip arthroplasty.

Management of coccygodynia: talking points from a systematic review of recent clinical trials. (2025)
Journal Article
Mazzoleni, M. G., Maffulli, N., Bardazzi, T., Memminger, M., Bertini, F. A., Migliorini, F., …Bertini, F. A. (2025). Management of coccygodynia: talking points from a systematic review of recent clinical trials. Annals of Joint, 10, 9. https://doi.org/10.21037/aoj-24-40

Coccygodynia, characterised by localised pain in the coccyx and surrounding tissues, presents challenges in diagnosis and management given its low prevalence and varied aetiology. Traumatic injury, particularly backward falls, is commonly implicated,... Read More about Management of coccygodynia: talking points from a systematic review of recent clinical trials..

The ligamentum teres and its role in hip arthroscopy for femoroacetabular impingement: a systematic review (2024)
Journal Article
Migliorini, F., Cocconi, F., Bardazzi, T., Masoni, V., Gardino, V., Pipino, G., & Maffulli, N. (in press). The ligamentum teres and its role in hip arthroscopy for femoroacetabular impingement: a systematic review. Journal of Orthopaedics and Traumatology, 25(1), Article 68. https://doi.org/10.1186/s10195-024-00810-1

Background: The ligamentum teres (LT) has received attention in patients undergoing hip arthroscopy (HA) for femoroacetabular impingement (FAI). Indeed, a better understanding of the function of the LT and its implications for clinical outcomes in th... Read More about The ligamentum teres and its role in hip arthroscopy for femoroacetabular impingement: a systematic review.

Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. (2024)
Journal Article
Migliorini, F., Schäfer, L., Pilone, M., Bell, A., Simeone, F., & Maffulli, N. (in press). Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Archives of Orthopaedic and Trauma Surgery, 145(1), 68. https://doi.org/10.1007/s00402-024-05614-w

The present meta-analysis compared the efficacy of intra-articular hyaluronic acid (HA) injections in patients with early to mild knee osteoarthritis (OA) (Kellgren Lawrence I-II) versus other commonly injected biologically active compounds using pat... Read More about Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis..

Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts (2024)
Journal Article
Muruganandam, A., Migliorini, F., Jeyaraman, N., Vaishya, R., Balaji, S., Ramasubramanian, S., …Jeyaraman, M. (in press). Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts. Medical Sciences, 12(4), 1-15. https://doi.org/10.3390/medsci12040072

Rheumatoid arthritis (RA) represents an autoimmune condition impacted by a combination of genetic and environmental factors, with the gut microbiome (GMB) being one of the influential environmental factors. Patients with RA display notable modificati... Read More about Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts.

Arthroscopic lateral ligament reconstruction for isolated chronic lateral ankle instability is associated with longer recovery compared to arthroscopic Broström repair and inferior extensor retinaculum augmentation. (2024)
Journal Article
Feng, S.-M., Sun, Q.-Q., Xue, C., Maffulli, N., Oliva, F., & Luo, X. (2025). Arthroscopic lateral ligament reconstruction for isolated chronic lateral ankle instability is associated with longer recovery compared to arthroscopic Broström repair and inferior extensor retinaculum augmentation. Injury, 56(2), 112082. https://doi.org/10.1016/j.injury.2024.112082

Patients with chronic lateral ankle instability (CLAI) can be managed with arthroscopic Broström repair and inferior extensor retinaculum augmentation or arthroscopic assisted lateral ligament reconstruction using ipsilateral semitendinosus autograft... Read More about Arthroscopic lateral ligament reconstruction for isolated chronic lateral ankle instability is associated with longer recovery compared to arthroscopic Broström repair and inferior extensor retinaculum augmentation..

Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review (2024)
Journal Article
Migliorini, F., Pilone, M., Schäfer, L., Bertini, F. A., Giorgino, R., & Maffulli, N. (in press). Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review. British Medical Bulletin, 1-11. https://doi.org/10.1093/bmb/ldae020

Introduction Anterior cruciate ligament (ACL) injuries in children and adolescents with open physes are common. Areas of agreement Evidence of ACL reconstruction using allografts in children with open physes is limited. Areas of controversy Whether t... Read More about Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review.

Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. (2024)
Journal Article
Maffulli, N., Christidis, G., Gougoulias, N., Christidis, P., Poku, D., Hassan, R., …Oliva, F. (in press). Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. British Medical Bulletin, 1-9. https://doi.org/10.1093/bmb/ldae019

The present prospective comparative study included patients with acute Achilles tendon rupture (ATR) who underwent percutaneous repair with one knot compared to percutaneous repair with two knots. All patients underwent the procedure under local anes... Read More about Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study..

No Effect of Cigarette Smoking in the Outcome of Arthroscopic Management for Femoroacetabular Impingement: A Systematic Review (2024)
Journal Article
Lucenti, L., Maffulli, N., Bardazzi, T., Pipino, G., Pappalardo, G., & Migliorini, F. (in press). No Effect of Cigarette Smoking in the Outcome of Arthroscopic Management for Femoroacetabular Impingement: A Systematic Review. Journal of Clinical Medicine, 13(23), https://doi.org/10.3390/jcm13237214

Background: The impact of smoking in arthroscopic surgery for femoroacetabolar impingement (FAI) is controversial. This systematic review updates and discusses current evidence on the influence of cigarette smoking on the outcome of arthroscopic mana... Read More about No Effect of Cigarette Smoking in the Outcome of Arthroscopic Management for Femoroacetabular Impingement: A Systematic Review.

Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis. (2024)
Journal Article
Migliorini, F., Giorgino, R., Mazzoleni, M. G., Schäfer, L., Bertini, F. A., & Maffulli, N. (in press). Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis. European Journal of Orthopaedic Surgery and Traumatology, 35(1), Article 20. https://doi.org/10.1007/s00590-024-04135-x

Intra-articular injections of ozone and hyaluronic acid (HA) are routinely performed for the management of knee osteoarthritis. The present meta-analysis compared intra-articular injections of HA versus ozone in patients with knee osteoarthritis (OA)... Read More about Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis..

Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2024)
Journal Article
Migliorini, F., Maffulli, N., Schäfer, L., Kubach, J., Betsch, M., & Pasurka, M. (in press). Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Pharmaceuticals, 17(11), Article 1557. https://doi.org/10.3390/ph17111557

The present meta-analysis investigated the efficacy of intra-articular hyaluronic acid (HA) injections for knee osteoarthritis. The outcomes of interest were the visual analogue scale (VAS) and Western Ontario McMaster Osteo-Arthritis Index (WOMAC) s... Read More about Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.