All Outputs (3)

Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery (2018)
Journal Article
Foley, D. W., Pathak, R. B., Phillips, T. R., Wilson, G. L., Bailey, P. D., Pieri, M., …Meredith, D. (2018). Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery. European Journal of Medicinal Chemistry, 156, 180-189. https://doi.org/10.1016/j.ejmech.2018.06.064

The broad substrate capacity of the intestinal oligopeptide transporter, PepT1, has made it a key target of research into drug delivery. Whilst the substrate capacity of this transporter is broad, studies have largely been limited to small peptides a... Read More about Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery.

Active Learning Techniques to Build Problem Solving Skills in Chemistry Students (2018)
Journal Article
Brown, N., Howe, C., Jones, G., & Phillips, T. (2018). Active Learning Techniques to Build Problem Solving Skills in Chemistry Students. The Journal of Academic Development and Education, https://doi.org/10.21252/KEELE-0000025

Through the introduction of Team-Based Learning problem classes and a ‘Purple Pens’ feedback intervention in which students write their own feedback on a mixed formative and summative class test we have been able to observe a significant increase in... Read More about Active Learning Techniques to Build Problem Solving Skills in Chemistry Students.

Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids (2013)
Journal Article
Bailey, P. D., Beard, M. A., Cresswell, M., Dang, H. P., Pathak, R. B., Phillips, T. R., & Price, R. A. (2013). Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids. Tetrahedron Letters, 54(13), 1726-1729. https://doi.org/10.1016/j.tetlet.2013.01.074

Careful choice of the N-protecting group provides crucial conformational control, allowing ring-closure to the indole 3-position in the late stages of the synthesis of ajmaline alkaloids; the choice of protecting group and reducing agent can also pro... Read More about Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids.