All Outputs (20)

Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer (2019)
Thesis
Foulkes, R. L. (2019). Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is well known for its extremely high death rate, with the current treatments purely used to extend and better the quality of the patient's life instead of providing a “cure”. Because of this, novel drug delivery methods are being lo... Read More about Antimicrobial nano-ninjas as chaperones of gemcitabine for pancreatic cancer.

Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia (2019)
Thesis
Bratt, J. A. (2019). Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415216

Bronchopulmonary dysplasia (BPD) is a neonatal disease affecting the lungs of premature infants. Prematurely born infants have under-developed lungs and require invasive ventilation technologies to provide sufficient oxygen for survival. Artificial v... Read More about Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia.

Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers (2019)
Thesis
Sutton, E. R. (2019). Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417795

Cancer is a worldwide disease characterised by uncontrollable cell division and tumour growth making it a leading cause of death worldwide. The use of dietary products such a poly-unsaturated fatty acids (PUFAs) to reduce cancer growth is a current a... Read More about Investigating the possible mechanisms and gender effects of Omega-3 fatty acids on neuroblastoma, breast and prostate cancers.

Assessment of fracture risk tools in care home residents (2019)
Thesis
Ihama, F. E. (2019). Assessment of fracture risk tools in care home residents. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415215

Introduction
Fragility fractures are common in care home residents. National guidelines recommend risk assessment to allow initiation of prophylactic measures. Currently available risk assessment tools have been tested in community dwelling adults b... Read More about Assessment of fracture risk tools in care home residents.

Development of conjunctival and retinal models for improved eye disease treatments (2019)
Thesis
Gater, R. V. A. (2019). Development of conjunctival and retinal models for improved eye disease treatments. (Thesis). Keele University

Eye diseases such as glaucoma, macular degeneration and retinitis pigmentosa can lead to significant sight problems and blindness if left untreated. Current treatments are invasive, have a low success rate and lack the ability to regenerate damaged o... Read More about Development of conjunctival and retinal models for improved eye disease treatments.

A urinary proteomics investigation of pregnancy-related complications (2019)
Thesis
Al-Jasim, W. F. (2019). A urinary proteomics investigation of pregnancy-related complications. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414917

Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are common disorders associated with placental implantation abnormalities in early pregnancy. Both conditions are heterogeneous, having complex and multiple aetiologies. PE complicates 5-8... Read More about A urinary proteomics investigation of pregnancy-related complications.

The use of virtual patients for developing the evidence informed, shared decision making of clinicians (2019)
Thesis
Jacklin, S. (2019). The use of virtual patients for developing the evidence informed, shared decision making of clinicians. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414956

Background
Shared decision-making (SDM) involves a patient and a health professional sharing information to arrive at a decision that aligns with both the best available evidence and the patient’s preferences. Research shows that SDM is not occurrin... Read More about The use of virtual patients for developing the evidence informed, shared decision making of clinicians.

Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum (2019)
Thesis
Hmoud, M. K. (2019). Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414945

Despite the efforts in malaria eradication and elimination, malaria still poses a global challenge to health that, through the spread of antimalarial resistance, highlights an urgent need for new approaches for malaria treatment. Heparin and sulphate... Read More about Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum.

Applied statistical methods for prediction modelling of upper limb functional recovery after stroke (2019)
Thesis
Al-Shallawi, A. N. S. (2019). Applied statistical methods for prediction modelling of upper limb functional recovery after stroke. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414444

Stroke is the third largest cause of death in the world, with a significant contribution to disability. Motor function impairment, encompassing upper limb impairment, is the most significant post-stroke impairment. Such an impairment contributes to r... Read More about Applied statistical methods for prediction modelling of upper limb functional recovery after stroke.

Exploring the effects of gestational diabetes on placental membrane derived stem cells (2019)
Thesis
Chen, L. (2019). Exploring the effects of gestational diabetes on placental membrane derived stem cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414443

The progression of regenerative medicine and advanced cell banking technology provide the hope of using perinatal tissue-derived autologous MSCs for personalised medicine. Mesenchymal stem cells (MSCs) derived from placenta, with the advantages of be... Read More about Exploring the effects of gestational diabetes on placental membrane derived stem cells.

Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs) (2019)
Thesis
Sykes, J. G. (2019). Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs). (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414327

Autologous chondrocyte implantation (ACI) is the only UK approved cell therapy or knee cartilage defects which might otherwise progress to osteoarthritis. For ACI, chondrocytes isolated from a healthy cartilage biopsy are expanded in number prior to... Read More about Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs).

Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration (2019)
Thesis
Younus, Z. M. (2019). Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413770

Osteochondral defects are serious clinical problems relating to damaged articular cartilage within joints, usually resulting from acute traumatic injury or an underlying bone disorder. A variety of therapeutic options have been investigated, with sev... Read More about Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration.

Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders (2019)
Thesis
Hmeidi, H. (2019). Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413771

Current Lung function assessments in children can be clinically challenging and even inapplicable in preschool children, this is due to the test requirements of cooperation and understanding. Hence, there is a need for new techniques that can overcom... Read More about Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders.

Teaching decision-making and professional ethics for pharmacy practice: a mixed methods study (2019)
Thesis
Allinson, M. D. (2019). Teaching decision-making and professional ethics for pharmacy practice: a mixed methods study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413777

Little has been published on whether or not ethics teaching during undergraduate study effectively prepares pharmacy students for dealing with dilemmas in future practice. The aim of this study was to explore the user’s perspectives on the effectiven... Read More about Teaching decision-making and professional ethics for pharmacy practice: a mixed methods study.

Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells (2019)
Thesis
Ibrahim, . S. L. (2019). Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413776

Breast cancer is considered the most frequently diagnosed cancer in women and the second most common type of cancer causing deaths among women. It is accounts 25% of all female cancers. It is expected about 1 in 8 women will develop this disease duri... Read More about Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells.

Characterising microglial activation: refinement and validation of primary in vitro models (2019)
Thesis
Al-Shaheeb, S. (2019). Characterising microglial activation: refinement and validation of primary in vitro models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413772

Background: Neuroinflammation is common to many neurodegenerative conditions and is principally mediated by microglia. Microglia maintain homeostasis, respond to trauma/infection and can promote repair. This is achieved by switching between surveilla... Read More about Characterising microglial activation: refinement and validation of primary in vitro models.

Engineering and optimising a functional in vitro model of basal ganglia circuitry (2019)
Thesis
Kӧse-Dunn, M. J. (2019). Engineering and optimising a functional in vitro model of basal ganglia circuitry. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413812

The majority of neurological diseases (such as Parkinson’s and Huntington’s diseases) are progressive, debilitating and currently incurable. In an ageing population, the prevalence of such diseases will only increase over time, creating a need for be... Read More about Engineering and optimising a functional in vitro model of basal ganglia circuitry.

Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study (2019)
Thesis
Cork, T. A. (2019). Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414218

Background – Research has consistently shown that approximately 50% of patients do not take their prescribed medication correctly. A commonly overlooked factor in patient’s lack of understanding of health information and medicine instructions is limi... Read More about Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study.

Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis (2019)
Thesis
Moran, J. A. (2019). Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413132

The research described here considers molecular variations of the acute phase response protein, C reactive protein (CRP), and the presence of CRP and anti CRP autoantibodies in rheumatoid arthritis (RA) patient serum.
Monomeric CRP (mCRP) was genera... Read More about Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis.

Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models (2019)
Thesis
Muhammad Hassan, E. (2019). Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413084

Articular cartilage is a specialised tissue which covers the articulating surfaces at the end of the mammalian bone. This thin layer performs essential functions such as load bearing and shock absorption in joints. However, it lacks the ability to sa... Read More about Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models.