All Outputs (19)

Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex (2020)
Thesis
Harvey, L. A. (2020). Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex. (Thesis). Keele University

Projection neurons located in the superficial layers of the entorhinal cortex provide the hippocampus with nearly all its sensory input. This innervation occurs via multiple discrete pathways to different targets within the hippocampus, including the... Read More about Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex.

The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation (2020)
Thesis
Richardson, C. L. (2020). The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation. (Thesis). Keele University

Introduction
Patients commencing new medications, particularly those that are high risk such as non-vitamin K oral anticoagulants (NOACs), require counselling to ensure safe, effective and empowering use of the medicine. Pharmacists are well placed... Read More about The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation.

Translational studies to support the use of pitavastatin as a cancer therapeutic (2020)
Thesis
Jawad, M. J. (2020). Translational studies to support the use of pitavastatin as a cancer therapeutic. (Thesis). Keele University

Ovarian cancer is the fifth leading cause of death associated with cancer. Initially, the disease responds to surgical cytoreduction, followed by chemotherapy. The primary response rate for chemotherapy is about 80%. Unfortunately, most patients rela... Read More about Translational studies to support the use of pitavastatin as a cancer therapeutic.

Developing neural transplant cell sprays for neurological injuries (2020)
Thesis
Woods, W. A. (2020). Developing neural transplant cell sprays for neurological injuries. (Thesis). Keele University

Regeneration of the central nervous system following penetrating traumatic brain injury (pTBI) represents a significant clinical challenge. Neural cell therapies have the potential to promote regeneration in central neural injury. However, such thera... Read More about Developing neural transplant cell sprays for neurological injuries.

New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies (2020)
Thesis
Basit, R. H. (2020). New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418094

Penetrating traumatic brain injury (pTBI) causes significant neural damage and debilitation. The management of pTBI is largely supportive currently, with no clinically established regenerative therapies. Researchers have previously evaluated the rege... Read More about New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies.

Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways (2020)
Thesis
Šoltić, D. (2020). Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways. (Thesis). Keele University

Spinal muscular atrophy (SMA) is a debilitating genetic disorder, characterised by homozygous loss of the survival of motor neuron 1 (SMN1) gene, resulting in insufficient levels of ubiquitously expressed survival of motor neuron (SMN) protein. The t... Read More about Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways.

Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents (2020)
Thesis
Abdulrahman, M. F. A. (2020). Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents. (Thesis). Keele University

The rate-limiting step for oral absorption of hydrophobic drugs and solubility is the drug dissolution rate in the GI fluids. Several novel and traditional methods have been used to improve the solubility rates of poorly water soluble drugs. The prof... Read More about Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents.

An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research (2020)
Thesis
Shenton, J. J. L. (2020). An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417292

Background
Research in the NHS is essential to provide evidence to improve services and patient outcomes. The Government’s continued commitment to research has been made clear through the inclusion of research in key NHS policy documents including t... Read More about An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research.

Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum (2020)
Thesis
Famodimu, M. T. (2020). Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University

The emergence of P. falciparum resistant to current front-line artemisinin combination therapies underscores the urgent demand for new candidate molecules for a single exposure radical cure and prophylaxis drug. Developing a suitable candidate compon... Read More about Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum.

Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo (2020)
Thesis
Turner, D. C. (2020). Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo. (Thesis). Keele University

Skeletal muscle (SkM) is an extremely abundant and mechano-sensitive tissue, demonstrating increases in mass and function following mechanical loading/resistance exercise (RE). Over the past 3 decades, there has been considerable progress in the deve... Read More about Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo.

Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies (2020)
Thesis
Morgan, R. L. (2020). Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies. (Thesis). Keele University

Cells secrete small membrane-bound extracellular vesicles (sEVs) called exosomes. These vesicles contain a mixture of protein, lipids, nucleic acids and saccharides (known collectively as cargo) that mediate therapeutic effects similar to their produ... Read More about Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies.

Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis (2020)
Thesis
Kirkby, M. (2020). Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis. (Thesis). Keele University

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide that has been used extensively for the past half century as a topical antiseptic, due to its ability to effectively kill surface bacteria with minimal reports of resistance. However, bacteria... Read More about Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis.

Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer (2020)
Thesis
Ali Asgari, M. (2020). Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is the 4th most aggressive cancer in the Western world. There are very little drugs available as chemotherapies for the treatment of pancreatic cancer. Of the ones used, most of them become eliminated by first pass metabolism before... Read More about Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer.

Human cell therapies in preclinical and clinical studies of cartilage repair (2020)
Thesis
Perry, J. K. L. (2020). Human cell therapies in preclinical and clinical studies of cartilage repair. (Thesis). Keele University

Cell therapy offers potential to repair and regenerate damaged tissues. An established example of its use in the clinic is for treating cartilage defects. This thesis addresses this topic, both studying the use of imaging in such patients having had... Read More about Human cell therapies in preclinical and clinical studies of cartilage repair.

An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering (2020)
Thesis
Foster, N. C. (2020). An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering. (Thesis). Keele University

Articular cartilage is prone to degradation as a result of aging, disease and injury, which can lead to the onset of osteoarthritis (OA). The avascular nature of the tissue renders its endogenous repair capacity notoriously poor and its aneural natur... Read More about An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering.

Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core (2020)
Thesis
Jihad, T. W. J. (2020). Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core. (Thesis). Keele University

Calix[4]resorcinarenes functionalised with glycosidic ligands on their lower rim have received little interest compared to analogues bearing carbohydrates on the upper rim. In this study, series of novel macrocyclic glycoclusters bearing mono- or dis... Read More about Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core.

Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease (2020)
Thesis
Gómez Gálvez, Y. (2020). Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease. (Thesis). Keele University

The degeneration of dopaminergic neurons (DAn) in the midbrain substantia nigra pars compacta (SNpc) is a definitive feature of Parkinson's disease (PD). Although age has been established as one of the main risk factors, the role that ageing has in t... Read More about Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease.

Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation (2020)
Thesis
Berry, J. D. (2020). Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation. (Thesis). Keele University

Interprofessional education (IPE) has been proposed as a method of creating a collaborative practice ready workforce in healthcare. Postulated benefits of the technique include improving communication between professional groups, which in turn should... Read More about Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation.

Development of a novel doxorubicin delivery system for pancreatic cancer (2020)
Thesis
Al-Ameri, J. J. M. (2020). Development of a novel doxorubicin delivery system for pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is considered as the 4th most aggressive cancer in the Western world. There is a direct link between
pancreatic cancer diagnosis and patient age with high occurrence of the disease happening in the 65-75-year age group. The majori... Read More about Development of a novel doxorubicin delivery system for pancreatic cancer.