Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender.

Heagerty, A; Smith, A; English, J; Lear, J; Perkins, W; Bowers, B; Jones, P; Gilford, J; Alldersea, J; Fryer, A; Strange, RC

doi:10.1038/bjc.1996.8

Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. (1996)
Journal Article
Jahnke, V., Matthias, C., Fryer, A., & Strange, R. (1996). Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. American Journal of Surgery, 172(6), 671-673. https://doi.org/10.1016/s0002-9610%2896%2900298-x

Purpose
While cigarette smoking and alcohol consumption are recognized covariates for laryngeal carcinoma, the role of genetic factors in determining individual susceptibility is unknown. We describe the influence of polymorphism in carcinogen-metab... Read More about Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx..

Non-Hodgkin's lymphoma and solar ultraviolet radiation (1996)
Journal Article
Newton, R., Roman, E., Fear, N., Carpenter, L., Lear, J., Tan, B., …Jones, P. (1996). Non-Hodgkin's lymphoma and solar ultraviolet radiation. British medical journal, 313(7052), 298-299. https://doi.org/10.1136/bmj.313.7052.298

Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression (1996)
Journal Article
Sarhanis, P., Redman, C., Perrett, C., Brannigan, K., Clayton, R., Hand, P., …Strange, R. (1996). Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression. British journal of cancer, 1757 - 1761. https://doi.org/10.1038/bjc.1996.626

The importance of polymorphism in the glutathione S-transferase GSTM1, GSTT1 and, cytochrome P450, CYP2D6 loci in the pathogenesis of epithelial ovarian cancer has been assessed in two studies; firstly, a case-control study designed to determine the... Read More about Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression.

Association of homozygosity for glutathione-S-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. (1996)
Journal Article
Ollier, W., Davies, E., Snowden, N., Alldersea, J., Fryer, A., Jones, P., & Strange, R. (1996). Association of homozygosity for glutathione-S-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. Arthritis and Rheumatology, 39(10), 1763-1764. https://doi.org/10.1002/art.1780391023

Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. (1996)
Journal Article
Hand, P. A., Inskip, A., Gilford, J., Alldersea, J., Elexpuru-Camiruaga, J., Hayes, J. D., …Fryer, A. A. (1996). Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. Carcinogenesis, 17(9), 1919–1922. https://doi.org/10.1093/carcin/17.9.1919

We describe studies to assess the influence of polymorphism in the human glutathione S-transferase GSTM3 gene on susceptibility to high grade astrocytoma. Immunohisto-chemical studies using a GSTM3-specific antiserum identified expression of the GSTM... Read More about Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma..

Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. (1996)
Journal Article
Lear, J. T., Heagerty, A. H., Smith, A., Bowers, B., Rowland Payne, C., Dale Smith, C., …Strange, R. C. (1996). Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis, 17(9), 1891–1896. https://doi.org/10.1093/carcin/17.9.1891

The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number of tumours/year from first presentation) of furthe... Read More about Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual..

Non-Hodgkins lymphoma and solar ultraviolet radiation. Basal cell carcinoma may be linked to haematological malignancy. (1996)
Journal Article
Lear, J. T., Tan, B. B., Smith, A. G., Fryer, A. A., Strange, R. C., & Jones, P. W. (1996). Non-Hodgkins lymphoma and solar ultraviolet radiation. Basal cell carcinoma may be linked to haematological malignancy. BMJ, https://doi.org/10.1136/bmj.313.7052.298a

Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. (1996)
Journal Article
Yengi, L., Inskip, A., Gilford, J., Alldersea, J., Bailey, L., Smith, A., …Fryer, A. A. (1996). Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. Cancer Research, 56, 1974-1977

The influence of polymorphism in the glutathione S-transferase, GSTM3 gene on susceptibility to cutaneous basal cell carcinoma (BCC) has been investigated. We have reported previously two GSTM3 alleles, GSTM3*A and GSTM3*B, distinguished by a recogni... Read More about Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma..

Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. (1996)
Journal Article
Deakin, M., Elder, J., Hendrickkse, C., Peckham, D., Leopard, D., Bell, D. A., …Strange, R. C. (1996). Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, 17(4), 881–884. https://doi.org/10.1093/carcin/17.4.881

Allelism in glutathione S-transferase GSTM1 and GSTT1 has been suggested as a risk factor in various cancers. Accordingly, we describe a group of case-control studies carried out to identify associations between GSTT1 genotypes and susceptibility to... Read More about Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers..

Polymorphism in detoxifying enzymes and susceptibility to skin cancer. (1996)
Journal Article
Lear, J., Heagerty, A., Smith, A., Bowers, B., Jones, P., Gilford, J., …Strange, R. (1996). Polymorphism in detoxifying enzymes and susceptibility to skin cancer. Photochemistry and Photobiology, 63(4), 424-428. https://doi.org/10.1111/j.1751-1097.1996.tb03062.x

Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. (1996)
Journal Article
Heagerty, A., Smith, A., English, J., Lear, J., Perkins, W., Bowers, B., …Strange, R. (1996). Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. British journal of cancer, 73, 44 - 48. https://doi.org/10.1038/bjc.1996.8

The factors that determine development of single and multiple primary cutaneous basal cell carcinomas (BCCs) are unclear. We describe a case-control study firstly, to examine the influence of allelism at the glutathione S-transferase GSTM1 and GSTT1... Read More about Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender..

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