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All Outputs (329)

Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial (2017)
Journal Article
Hill, J. (2017). Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial. Trials, https://doi.org/10.1186/s13063-017-2279-7

Background
Back pain is a leading contributor to disability, healthcare costs, and lost work. Family physicians are the most common first point of contact in the healthcare system for people with back pain, but physiotherapists (PTs) may be able to... Read More about Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial.

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (2017)
Journal Article
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., …Wilkinson, C. Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica. Health Technology Assessment, 21(60), 1-180. https://doi.org/10.3310/hta21600

Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register (2017)
Journal Article
(2017). Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register. Arthritis and Rheumatology, 2144 - 2150. https://doi.org/10.1002/art.40185

Objective. To estimate the proportion of patients with axial spondyloarthritis (SpA) in a UK national biologics registry who met criteria for fibromyalgia (FM), and to delineate the characteristics of these patients. Methods. Two cohorts of patients... Read More about Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register.

Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U (2017)
Journal Article
Yang, X., Wang, C. C., Lee, W. Y. W., Trovik, J., Chung, T. K. H., & Kwong, J. (2018). Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. Cancer Letters, 413, 23-34. https://doi.org/10.1016/j.canlet.2017.10.028

Endometrioid endometrial carcinoma (EEC) is one of the common causes of cancer-related mortality in women. Mounting evidences suggest that long noncoding RNAs (lncRNAs) function in multiple cancers. In this study, we discovered that HAND2-AS1, a lncR... Read More about Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U.

Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). (2017)
Journal Article
Iskandar, I. Y., Warren, R. B., Lunt, M., Mason, K. J., Evans, I., McElhone, K., …Griffiths, C. E. (2018). Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). Journal of Investigative Dermatology, 138(4), 775 - 784. https://doi.org/10.1016/j.jid.2017.09.044

Little is known about the drug survival of second-line biologic therapies for psoriasis in routine clinical practice. We assessed drug survival of second-line biologic therapies and estimated the risk of recurrent discontinuation due to adverse event... Read More about Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR)..

A randomised trial of the influence of racial stereotype bias on examiners’ scores, feedback and recollections in undergraduate clinical exams (2017)
Journal Article
Yeates. (2017). A randomised trial of the influence of racial stereotype bias on examiners’ scores, feedback and recollections in undergraduate clinical exams. BMC Medicine, 179 -?. https://doi.org/10.1186/s12916-017-0943-0

Asian medical students and doctors receive lower scores on average than their white counterparts in examinations in the UK and internationally (a phenomenon known as “differential attainment”). This could be due to examiner bias or to social, psychol... Read More about A randomised trial of the influence of racial stereotype bias on examiners’ scores, feedback and recollections in undergraduate clinical exams.

Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders. (2017)
Journal Article
Farooq, S., Johal, R. K., Ziff, C., & Naeem, F. (2017). Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD011707.pub2

BACKGROUND: Delivering the diagnosis of a serious illness is an important skill in most fields of medicine, including mental health. Research has found that communication skills can impact on a person's recall and understanding of the diagnosis, trea... Read More about Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders..

Incidence, clinical management, and mortality risk following self harm among children and adolescents: cohort study in primary care (2017)
Journal Article
Chew-Graham, C. (2017). Incidence, clinical management, and mortality risk following self harm among children and adolescents: cohort study in primary care. BMJ, j4351 - ?. https://doi.org/10.1136/bmj.j4351

Objectives To examine temporal trends in sex and age specific incidence of self harm in children and adolescents, clinical management patterns, and risk of cause specific mortality following an index self harm episode at a young age.Design Population... Read More about Incidence, clinical management, and mortality risk following self harm among children and adolescents: cohort study in primary care.

Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial (2017)
Journal Article
Dziedzic, K., Hay, E., Porcheret, M., Afolabi, E., Lewis, A., Morden, A., …Healey, E. (2018). Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial. Osteoarthritis and Cartilage, 26(1), 43-53. https://doi.org/10.1016/j.joca.2017.09.010

Objective
To determine the effectiveness of a model osteoarthritis consultation, compared with usual care, on physical function and uptake of National Institute for Health and Care Excellence (NICE) osteoarthritis recommendations, in adults =45 year... Read More about Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial.

Meditation for asthma: Systematic review and meta-analysis (2017)
Journal Article
Paudyal, P., Jones, C., Grindey, C., Dawood, R., & Smith, H. (2018). Meditation for asthma: Systematic review and meta-analysis. Journal of Asthma, 55(7), 771-778. https://doi.org/10.1080/02770903.2017.1365887

Objective: To conduct a comprehensive review and meta-analysis of the effectiveness of meditation on a variety of asthma outcomes. Methods: We searched MEDLINE, EMBASE, CINAHL, PsycINFO and AMED in June 2016 to identify randomized controlled trials (... Read More about Meditation for asthma: Systematic review and meta-analysis.

Clinical classification criteria for neurogenic claudication caused by lumbar spinal stenosis. The N-CLASS criteria (2017)
Journal Article
(2017). Clinical classification criteria for neurogenic claudication caused by lumbar spinal stenosis. The N-CLASS criteria. Spine Journal, 941-947. https://doi.org/10.1016/j.spinee.2017.10.003

Background Context Since imaging findings of lumbar spinal stenosis (LSS) may not be associated with symptoms, clinical classification criteria based on patient symptoms and physical examination findings are needed. Purpose To develop clinical classi... Read More about Clinical classification criteria for neurogenic claudication caused by lumbar spinal stenosis. The N-CLASS criteria.

Using de-escalation strategies to prevent aggressive behaviour (2017)
Journal Article
(2017). Using de-escalation strategies to prevent aggressive behaviour. Mental Health Practice, 22-28. https://doi.org/10.7748/mhp.2017.e1221

Reducing the use of physical restraint in clinical practice, including face-down restraint, is a challenge for professionals. The aim of this literature review was to assess the use of de-escalation techniques to prevent aggressive behaviour or decre... Read More about Using de-escalation strategies to prevent aggressive behaviour.

Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population (2017)
Journal Article
Lawson, C. A., Jones, P. W., Teece, L., Dunbar, S. B., Seferovic, P. M., Khunti, K., …Kadam, U. T. (2018). Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population. JACC: Heart Failure, 6(1), 18-26. https://doi.org/10.1016/j.jchf.2017.08.020

Objectives
This study sought to investigate in the general heart failure (HF) population, whether the associations between type 2 diabetes (T2D) and risk of hospitalization and death, are modified by changing glycemic or drug treatment intensity.... Read More about Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population.

A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer (2017)
Journal Article
Wang, J., Man, G. C. W., Chan, T. H., Kwong, J., & Wang, C. C. (2018). A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer. Cancer Letters, 412, 10-20. https://doi.org/10.1016/j.canlet.2017.09.054

Anti-angiogenesis effect of a prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) in malignant tumors is not well studied. Here, we investigated how the treatment with Pro-EGCG inhibited tumor angiogenesis in endometrial cancer.... Read More about A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer.