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All Outputs (329)

A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer (2017)
Journal Article
Wang, J., Man, G. C. W., Chan, T. H., Kwong, J., & Wang, C. C. (2018). A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer. Cancer Letters, 412, 10-20. https://doi.org/10.1016/j.canlet.2017.09.054

Anti-angiogenesis effect of a prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) in malignant tumors is not well studied. Here, we investigated how the treatment with Pro-EGCG inhibited tumor angiogenesis in endometrial cancer.... Read More about A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer.

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts. (2017)
Journal Article
(2017). Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts. Twin Research and Human Genetics, 395 -405. https://doi.org/10.1017/thg.2017.49

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual,... Read More about Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts..

External validation, update and development of prediction models for pre-eclampsia using an Individual Participant Data (IPD) meta-analysis: the International Prediction of Pregnancy Complication Network (IPPIC pre-eclampsia) protocol. (2017)
Journal Article
(2017). External validation, update and development of prediction models for pre-eclampsia using an Individual Participant Data (IPD) meta-analysis: the International Prediction of Pregnancy Complication Network (IPPIC pre-eclampsia) protocol. Diagnostic and Prognostic Research, 16 - ?. https://doi.org/10.1186/s41512-017-0016-z

Background: Pre-eclampsia, a condition with raised blood pressure and proteinuria is associated with an increased risk of maternal and offspring mortality and morbidity. Early identification of mothers at risk is needed to target management. Methods/... Read More about External validation, update and development of prediction models for pre-eclampsia using an Individual Participant Data (IPD) meta-analysis: the International Prediction of Pregnancy Complication Network (IPPIC pre-eclampsia) protocol..

The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica (2017)
Journal Article
Mackie, S., Neill, L., Harrison, E., Black, R., Kermani, T., Simon, L., …Twohig, H. (2017). The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica. Journal of Rheumatology, 1515-1521. https://doi.org/10.3899/jrheum.161109

OBJECTIVE
To inform development of a core domain set for outcome measures for clinical trials in polymyalgia rheumatica (PMR), we conducted patient consultations, a systematic review, a Delphi study, and 2 qualitative studies.

METHODS
Domains i... Read More about The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica.

Using realist evaluation to explain preparedness for doctors’ memorable 'firsts' (2017)
Journal Article
Lefroy. (2017). Using realist evaluation to explain preparedness for doctors’ memorable 'firsts'. Medical Education, 1037-1048. https://doi.org/10.1111/medu.13370

CONTEXT: Doctors must be competent from their first day of practice if patients are to be safe. Medical students and new doctors are acutely aware of this, but describe being variably prepared.

OBJECTIVES: This study aimed to identify causal chai... Read More about Using realist evaluation to explain preparedness for doctors’ memorable 'firsts'.

Clinical classification criteria for radicular pain caused by lumbar disc herniation: the RAPIDH criteria (RAdicular PaIn caused by Disc Herniation) (2017)
Journal Article
(2017). Clinical classification criteria for radicular pain caused by lumbar disc herniation: the RAPIDH criteria (RAdicular PaIn caused by Disc Herniation). Spine Journal, 1464-1471. https://doi.org/10.1016/j.spinee.2017.05.005

Background Context
Classification criteria are recommended for diseases that lack specific biomarkers to improve homogeneity in clinical research studies. Because imaging evidence of lumbar disc herniations (LDHs) may not be associated with symptoms... Read More about Clinical classification criteria for radicular pain caused by lumbar disc herniation: the RAPIDH criteria (RAdicular PaIn caused by Disc Herniation).

Measuring Musculoskeletal Pain in Infants, Children, and Adolescents. (2017)
Journal Article
Michaleff, Z., Kamper, S., Stinson, J., Hestbaek, L., Williams, C., Campbell, P., & Dunn, K. (2017). Measuring Musculoskeletal Pain in Infants, Children, and Adolescents. Journal of Orthopaedic & Sports Physical Therapy, 712 - 730. https://doi.org/10.2519/jospt.2017.7469

Synopsis Accurate, reliable, and timely assessment of pain is critical for effective management of musculoskeletal pain conditions. The assessment of pain in infants, children, and adolescents with and without cognitive impairment can be particularly... Read More about Measuring Musculoskeletal Pain in Infants, Children, and Adolescents..

Higher medical training in Rheumatology in the UK: any lessons worth learning? (2017)
Journal Article
Hassell, A. Higher medical training in Rheumatology in the UK: any lessons worth learning?. Mediterranean Journal of Rheumatology, 28(4), 171-173. https://doi.org/10.31138/mjr.28.4.171

Across Europe, provision of high quality care for people with rheumatological conditions is at least partly dependent upon the rheumatologist, who generally plays a key role in making a diagnosis and in co-ordinating a patient’s care. In addition, i... Read More about Higher medical training in Rheumatology in the UK: any lessons worth learning?.

Qualitative research using realist evaluation to explain preparedness for doctors' memorable 'firsts' (2017)
Journal Article
Lefroy, J., Yardley, S., Kinston, R., Gay, S., McBain, S., & McKinley, R. (2017). Qualitative research using realist evaluation to explain preparedness for doctors' memorable 'firsts'. Medical Education, 1037-1048. https://doi.org/10.1111/medu.13370

CONTEXT: Doctors must be competent from their first day of practice if patients are to be safe. Medical students and new doctors are acutely aware of this, but describe being variably prepared.

OBJECTIVES: This study aimed to identify causal chai... Read More about Qualitative research using realist evaluation to explain preparedness for doctors' memorable 'firsts'.

Mediators of Treatment Effect in the Back In Action Trial: Using Latent Growth Modeling to Take Change Over Time into Account. (2017)
Journal Article
Mansell, G., Hill, J., Main, C. J., Von Korff, M., & Van Der Windt, D. (2017). Mediators of Treatment Effect in the Back In Action Trial: Using Latent Growth Modeling to Take Change Over Time into Account. Clinical Journal of Pain, 33(9), 811-819. https://doi.org/10.1097/AJP.0000000000000463

OBJECTIVES: To test whether change in fear-avoidance beliefs was a mediator of the effect of treatment on disability outcome; To test an analytical approach, latent growth modelling, not often applied to mediation analysis.

METHODS: Secondary ana... Read More about Mediators of Treatment Effect in the Back In Action Trial: Using Latent Growth Modeling to Take Change Over Time into Account..

Understanding cultural influences on back pain and back pain research (2017)
Journal Article
(2017). Understanding cultural influences on back pain and back pain research. Best Practice and Research: Clinical Rheumatology, https://doi.org/10.1016/j.berh.2017.08.004

Low back pain is highly prevalent and places a considerable burden on individuals, their families and communities. This back pain burden is unequally distributed around the world and within populations. Clinicians and researchers addressing back pain... Read More about Understanding cultural influences on back pain and back pain research.

Pain and learning in primary school: a population-based study (2017)
Journal Article
Kosola, S., Mundy, L. K., Sawyer, S. M., Canterford, L., van der Windt, D. A., Dunn, K. M., & Patton, G. C. (2017). Pain and learning in primary school: a population-based study. PAIN, 158(9), 1825-1830. https://doi.org/10.1097/j.pain.0000000000000984

Despite the frequency of pain among children, little is known about its effects on learning and school outcomes. The objective of this study was to quantify the association of pain and academic achievement while taking into account the presence of co... Read More about Pain and learning in primary school: a population-based study.

Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study. (2017)
Journal Article
Spiers, J., Buszewicz, M., Chew-Graham, C. A., Gerada, C., Kessler, D., Leggett, N., …Riley, R. (2017). Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study. British Journal of General Practice (BJGP), 700-708. https://doi.org/10.3399/bjgp17X692573

BACKGROUND: GPs are under increasing pressure due to a lack of resources, a diminishing workforce, and rising patient demand. As a result, they may feel stressed, burnt out, anxious, or depressed. AIM: To establish what might help or hinder GPs exper... Read More about Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study..

The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control (2017)
Journal Article
Dunn, K., Campbell, P., & Hope, K. (2017). The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control. Journal of Pain Research, https://doi.org/10.2147/JPR.S139445

Low back pain (LBP) is common, impacts on the individual and society, and is a major health concern. Psychological consequences of LBP, such as depression, are significant barriers to recovery, but mechanisms for the development of depression are les... Read More about The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control.

Chronic pain in families: a cross-sectional study of shared social, behavioural, and environmental influences (2017)
Journal Article
Campbell, P., Jordan, K., Dunn, K., & Smith, B. (2017). Chronic pain in families: a cross-sectional study of shared social, behavioural, and environmental influences. PAIN, 41-47. https://doi.org/10.1097/j.pain.0000000000001062

Chronic pain is common and creates a significant burden to the individual and society. Emerging research has shown the influence of the family environment on pain outcomes. However, it is not clear what shared factors between family members associate... Read More about Chronic pain in families: a cross-sectional study of shared social, behavioural, and environmental influences.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article
Swaithes. (2017). Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-017-1761-4

Background
The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Measuring the statistical validity of summary meta-analysis and meta-regression results for use in clinical practice (2017)
Journal Article
(2017). Measuring the statistical validity of summary meta-analysis and meta-regression results for use in clinical practice. Statistics in Medicine, 3283 -3301. https://doi.org/10.1002/sim.7372

An important question for clinicians appraising a meta-analysis is: are the findings likely to be valid in their own practice-does the reported effect accurately represent the effect that would occur in their own clinical population? To this end we a... Read More about Measuring the statistical validity of summary meta-analysis and meta-regression results for use in clinical practice.