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All Outputs (209)

Hydroxypropylmethacrylamide based thermoresponsive magnetomicelles for controllable drug delivery in pancreatic cancer (2018)
Thesis
Alsuraifi, A. T. Y. (2018). Hydroxypropylmethacrylamide based thermoresponsive magnetomicelles for controllable drug delivery in pancreatic cancer. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412030

Thermo-responsive polymers are a class of smart polymers that respond to change in temperature. This property makes this type of polymers useful materials in a wide range of applications especially, in the field of drug delivery system. Polymers, whi... Read More about Hydroxypropylmethacrylamide based thermoresponsive magnetomicelles for controllable drug delivery in pancreatic cancer.

Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis (2018)
Thesis
Ditchfield, N. (2018). Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417942

Kidney damage in cystic fibrosis (CF) patients is most commonly caused by antibiotics, such as aminoglycosides, which are used to treat Pseudomonas aeruginosa (PA). I conducted a survey of UK CF centres which showed a high rate of use of aminoglycosi... Read More about Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis.

Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. (2018). Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.

A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials (2018)
Thesis
Potts, J. E. (2018). A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412318

Most analyses in stroke clinical trials assess the primary outcome at a single time point and do not consider conducting a longitudinal analysis, even when the outcome has been recorded at several time points. Efforts to improve the quality of statis... Read More about A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials.

Biosimilars: market analysis and survey of factors influencing prescribing (2018)
Thesis
Aladul, M. (2018). Biosimilars: market analysis and survey of factors influencing prescribing. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412316

Background: Biological medicines are effective but expensive options for treating patients with chronic and life-threatening diseases unresponsive to conventional small molecule medicines. The importance of biosimilars as an alternative to expensive... Read More about Biosimilars: market analysis and survey of factors influencing prescribing.

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article
Holmes, A. M., Heylings, J. R., Wan, K., & Moss, G. P. (2019). Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. International Journal of Antimicrobial Agents, 53(4), 500-507. https://doi.org/10.1016/j.ijantimicag.2018.12.012

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. (2018)
Journal Article
Slater, N., Rowley, C., Venables, R., White, S., & Frisher, M. (2018). Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. BMJ Open, 8(12), https://doi.org/10.1136/bmjopen-2018-025394

OBJECTIVES: Conflicting results have been reported when the associations between metabolic health, obesity and depression were examined previously. The primary aim of this study was to determine whether metabolic health or obesity are independently a... Read More about Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up..

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life (2018)
Journal Article
(2019). The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life. Seminars in Arthritis and Rheumatism, 49(1), 20-26. https://doi.org/10.1016/j.semarthrit.2018.12.006

Objective
Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them... Read More about The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life.

Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database (2018)
Journal Article
Mamas. (2018). Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 2480-2491. https://doi.org/10.1016/j.jcin.2018.09.035

Objectives
Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected left main stem percutaneou... Read More about Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database.

A virtual patient educational programme to teach counselling to clinical pharmacists-development and proof of concept (2018)
Presentation / Conference
Richardson, C., White, S., & Chapman, S. (2018, December). A virtual patient educational programme to teach counselling to clinical pharmacists-development and proof of concept. Poster presented at Prescribing and Research in Medicines Management (UK & Ireland) Annual Conference 2018, NCVO, Society Building, London, UK

Conference abstract, presented at Prescribing and Research in Medicines Management (UK & Ireland) Annual Conference 2018, NCVO, Society Building, London, UK, 14th December 2018: ‘Person-centred Care in the Digital Age: Nudge, Nudge, Tweet, Tweet’

ERa PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. (2018)
Journal Article
(2018). ERa PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. Journal of Orthopaedic Surgery and Research, 316 - ?. https://doi.org/10.1186/s13018-018-1020-x

BACKGROUND: Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons... Read More about ERa PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study..

Dose escalated simultaneous integrated boost radiotherapy for women treated by breast conservation surgery for early breast cancer: 3-year adverse effects in the IMPORT HIGH trial (CRUK/06/003) (2018)
Presentation / Conference
Coles, C., Griffin, C., Kirby, A., Haviland, J., Titley, J., Benstead, K., …Yarnold, J. (2018, December). Dose escalated simultaneous integrated boost radiotherapy for women treated by breast conservation surgery for early breast cancer: 3-year adverse effects in the IMPORT HIGH trial (CRUK/06/003). Presented at 2018 San Antonio Breast Cancer Symposium, San Antonio, Texas, USA

Meeting abstract (Abstract GS4-05 from 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas).

Disparities in mortality among 25–44-year-olds in England: a longitudinal, population-based study (2018)
Journal Article
(2018). Disparities in mortality among 25–44-year-olds in England: a longitudinal, population-based study. The Lancet Public Health, 567 -575. https://doi.org/10.1016/S2468-2667%2818%2930177-4

Summary Background Since the mid-1990s, excess mortality has increased markedly for adults aged 25–44 years in the north compared with the south of England. We examined the underlying causes of this excess mortality and the contribution of socioecono... Read More about Disparities in mortality among 25–44-year-olds in England: a longitudinal, population-based study.

Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis (2018)
Journal Article
Wong, C., Kwok, C., Narain, A., Gulati, M., Mihalidou, A., Wu, P., …Mamas, M. (2018). Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis. Heart, 1937-1948. https://doi.org/10.1136/heartjnl-2018-313005

Background The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD.... Read More about Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis.

Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility? (2018)
Journal Article
Davies. (2018). Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?. Kidney International, 1050 -1052. https://doi.org/10.1016/j.kint.2018.09.012

Peritoneal dialysis technique survival remains challenging due to peritonitis and long-term alterations to peritoneal membrane function and integrity. Up to now, the development of less bio-incompatible dialysis solutions have not had a major impact... Read More about Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?.

Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation (2018)
Journal Article
Mamas. (2018). Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation. Heart, 2058-2066. https://doi.org/10.1136/heartjnl-2018-313356

OBJECTIVES
To investigate the association of the CharlsonComorbidity Index (CCI) with clinical outcomes after transcatheter aortic valve implantation (TAVI).

BACKGROUND: Patients undergoing TAVI have high comorbid burden; however, there is limite... Read More about Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation.

Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types. (2018)
Journal Article
Dale, T. P., & Forsyth, N. R. (in press). Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types. BioResearch Open Access, 7(1), 10 - 24. https://doi.org/10.1089/biores.2018.0008

The poor healing capacity of cartilage and lack of effective treatment for associated disease and trauma makes it a strong candidate for a regenerative medicine approach. Potential therapies tested to date, although effective, have met with a number... Read More about Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types..

The potential of magnetic hyperthermia for triggering the differentiation of cancer cells (2018)
Journal Article
Moise, S., Byrne, J. M., El Haj, A. J., & Telling, N. D. (2018). The potential of magnetic hyperthermia for triggering the differentiation of cancer cells. Nanoscale, 10(44), 20519-20525. https://doi.org/10.1039/c8nr05946b

Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro an... Read More about The potential of magnetic hyperthermia for triggering the differentiation of cancer cells.