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Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning. (2020)
Journal Article
Riedel, G., Wulff, P., Marshall-Phelps, K., & Woloszynowska-Fraser, M. (2020). Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning. Scientific reports, 20000 - ?. https://doi.org/10.1038/s41598-020-76729-4

Purkinje cells are the only output cell of the cerebellar cortex. Their spatiotemporal activity is controlled by molecular layer interneurons (MLIs) through GABAA receptor-mediated inhibition. Recently, it has been reported that the cerebellar cortex... Read More about Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning..

Distribution of contemporary sensitivity troponin in the emergency department and relationship to 30-day mortality: The CHARIOT-ED substudy. (2020)
Journal Article
Mamas. (2020). Distribution of contemporary sensitivity troponin in the emergency department and relationship to 30-day mortality: The CHARIOT-ED substudy. Clinical Medicine, 528 - 534. https://doi.org/10.7861/clinmed.2020-0267

BACKGROUND: Contemporary sensitivity troponin (cs-cTn) concentrations above the upper limit of normal (ULN) are seen in a wide range of clinical conditions and evidence is growing that suggests cs-cTn may be a biomarker of future morbidity and mortal... Read More about Distribution of contemporary sensitivity troponin in the emergency department and relationship to 30-day mortality: The CHARIOT-ED substudy..

Exercise/physical activity and health outcomes: an overview of Cochrane systematic reviews (2020)
Journal Article
Pieper, D., Bajpai, R., Posadzki, P., Makaruk, H., Könsgen, N., Neuhaus, A. L., & Semwal, M. (2020). Exercise/physical activity and health outcomes: an overview of Cochrane systematic reviews. BMC Public Health, 20(1), Article ARTN 1724. https://doi.org/10.1186/s12889-020-09855-3

BACKGROUND: Sedentary lifestyle is a major risk factor for noncommunicable diseases such as cardiovascular diseases, cancer and diabetes. It has been estimated that approximately 3.2 million deaths each year are attributable to insufficient levels of... Read More about Exercise/physical activity and health outcomes: an overview of Cochrane systematic reviews.

Exploring classroom willingness to communicate: the role of motivating future L2 selves (2020)
Journal Article
Shen, S., Mazgutova, D., & McCray, G. (2020). Exploring classroom willingness to communicate: the role of motivating future L2 selves. International Journal of Educational Methodology, 6(4), 729-743

This study investigated the link between future L2 selves and Willingness to Communicate (WTC) in the classroom in the UK university context. We applied a mixed methods approach to collect data from 121 Chinese overseas students where a questionnaire... Read More about Exploring classroom willingness to communicate: the role of motivating future L2 selves.

What Proportion of Patients with Bone and Soft Tissue Tumors Contracted Coronavirus-19 and Died From Surgical Procedures During the Initial Period of the COVID-19 Pandemic? Results From the Multicenter British Orthopaedic Oncology Society Observational Study (2020)
Journal Article
Rajasekaran, R. B., Ashford, R. U., Cosker, T. D. A., Stevenson, J. D., Jeys, L., Pollock, R., …Cool, W. (2021). What Proportion of Patients with Bone and Soft Tissue Tumors Contracted Coronavirus-19 and Died From Surgical Procedures During the Initial Period of the COVID-19 Pandemic? Results From the Multicenter British Orthopaedic Oncology Society Observational Study. Clinical Orthopaedics and Related Research, 479(5), 1158-1166. https://doi.org/10.1097/corr.0000000000001568

Delivering uninterrupted cancer treatment to patients with musculoskeletal tumors has been essential during the rapidly evolving coronavirus 2019 (COVID-19) pandemic, as delays in management can be detrimental. Currently, the risk of contracting COVI... Read More about What Proportion of Patients with Bone and Soft Tissue Tumors Contracted Coronavirus-19 and Died From Surgical Procedures During the Initial Period of the COVID-19 Pandemic? Results From the Multicenter British Orthopaedic Oncology Society Observational Study.

Barriers to access and ways to improve dementia services for a minority ethnic group in England (2020)
Journal Article
(2020). Barriers to access and ways to improve dementia services for a minority ethnic group in England. Journal of Evaluation in Clinical Practice, 1629-1637. https://doi.org/10.1111/jep.13361

Rationale, aims and objectives: Much emphasis has been placed on the lack of awareness and understanding of dementia that exist within the ethnic minority groups in the UK. There has been a continual dearth of research, however, among the ethnic mino... Read More about Barriers to access and ways to improve dementia services for a minority ethnic group in England.

Abstract 15368: Index Admission and Thirty-day Readmission Outcomes of Cancer Patients Presenting With Stemi (2020)
Journal Article
Osman, M., Benjamin, M. M., Balla, S., Kheiri, B., Bianco, C., sengupta, P., …Patel, B. (2020). Abstract 15368: Index Admission and Thirty-day Readmission Outcomes of Cancer Patients Presenting With Stemi. Circulation, 142(Suppl_3), https://doi.org/10.1161/circ.142.suppl_3.15368

Introduction: National-level data of cancer patients’ readmissions after a ST-segment elevation myocardial infarction (STEMI) are lacking.

Objectives: The primary aim of this study was to describe rates and causes of 30-day readmissions in this po... Read More about Abstract 15368: Index Admission and Thirty-day Readmission Outcomes of Cancer Patients Presenting With Stemi.

Protocol for a systematic review on the methodological and reporting quality of prediction model studies using machine learning techniques (2020)
Journal Article
Andaur Navarro, C. L., Damen, J. A. A. G., Takada, T., Nijman, S. W. J., Dhiman, P., Ma, J., …Hooft, L. (2020). Protocol for a systematic review on the methodological and reporting quality of prediction model studies using machine learning techniques. BMJ Open, 10(11), Article e038832. https://doi.org/10.1136/bmjopen-2020-038832

INTRODUCTION: Studies addressing the development and/or validation of diagnostic and prognostic prediction models are abundant in most clinical domains. Systematic reviews have shown that the methodological and reporting quality of prediction model s... Read More about Protocol for a systematic review on the methodological and reporting quality of prediction model studies using machine learning techniques.

Co-prescription of gabapentinoids and opioids among adults with and without osteoarthritis in the United Kingdom between 1995 and 2017 (2020)
Journal Article
Yu, Appleyard, T., Cottrell, E., & Peat, G. (2021). Co-prescription of gabapentinoids and opioids among adults with and without osteoarthritis in the United Kingdom between 1995 and 2017. Rheumatology, 60(4), 1942-1950. https://doi.org/10.1093/rheumatology/keaa586

Objectives
To produce national and regional estimates and trends of gabapentinoid-opioid co-prescribing rates in patients with osteoarthritis, both in absolute terms and relative to matched controls without osteoarthritis.

Methods
Using the UK C... Read More about Co-prescription of gabapentinoids and opioids among adults with and without osteoarthritis in the United Kingdom between 1995 and 2017.

Characteristics and outcomes of COVID-19 associated stroke: a UK multicentre case-control study (2020)
Journal Article
Perry, R. J., Smith, C. J., Roffe, C., Simister, R., Narayanamoorthi, S., Marigold, R., …Werring, D. J. (2021). Characteristics and outcomes of COVID-19 associated stroke: a UK multicentre case-control study. Journal of Neurology, Neurosurgery and Psychiatry, 92(3), 242-248. https://doi.org/10.1136/jnnp-2020-324927

Objective We set out to determine which characteristics and outcomes of stroke are associated with COVID-19.

Methods This case-control study included patients admitted with stroke to 13 hospitals in England and Scotland between 9 March and 5 July... Read More about Characteristics and outcomes of COVID-19 associated stroke: a UK multicentre case-control study.

Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials (2020)
Journal Article
Quicke, J., Runhaar, J., Van Der Windt, D., Healey, E., Foster, N., & Holden, M. (2020). Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials. Osteoarthritis and Cartilage Open, 2(4), Article 100113. https://doi.org/10.1016/j.ocarto.2020.100113

Objective
1) To identify potential moderators of the effect of therapeutic exercise explored in randomised controlled trials (RCTs) of knee and hip osteoarthritis (OA); 2) summarise the extent, strength and quality of evidence reported for moderator... Read More about Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials.

Minimum sample size for external validation of a clinical prediction model with a continuous outcome. (2020)
Journal Article
(2020). Minimum sample size for external validation of a clinical prediction model with a continuous outcome. Statistics in Medicine, https://doi.org/10.1002/sim.8766

Clinical prediction models provide individualized outcome predictions to inform patient counseling and clinical decision making. External validation is the process of examining a prediction model's performance in data independent to that used for mod... Read More about Minimum sample size for external validation of a clinical prediction model with a continuous outcome..

Acceptability of bisphosphonates among patients, clinicians and managers: a systematic review and framework synthesis (2020)
Journal Article
Paskins, Z., Crawford-Manning, F., Cottrell, E., Corp, N., Wright, J., Jinks, C., …Sahota, O. (2020). Acceptability of bisphosphonates among patients, clinicians and managers: a systematic review and framework synthesis. BMJ Open, 10(11), https://doi.org/10.1136/bmjopen-2020-040634

OBJECTIVE: To explore the acceptability of different bisphosphonate regimens for the treatment of osteoporosis among patients, clinicians and managers, payers and academics. DESIGN: A systematic review of primary qualitative studies. Seven databases... Read More about Acceptability of bisphosphonates among patients, clinicians and managers: a systematic review and framework synthesis.

Islam and Mental Disorders of the Older Adults: Religious Text, Belief System and Caregiving Practices (2020)
Journal Article
Daher-Nashif, S., Hammad, S. H., Kane, T., & Al-Wattary, N. (2021). Islam and Mental Disorders of the Older Adults: Religious Text, Belief System and Caregiving Practices. Journal of Religion and Health, 60(3), 2051-2065. https://doi.org/10.1007/s10943-020-01094-5

This paper illustrates the impact of Islamic religious texts on dementia care in the Middle East. It examines how old age and older adults mental disorders are framed in the Quran and Hadith, and how these texts are transformed to belief ideologies a... Read More about Islam and Mental Disorders of the Older Adults: Religious Text, Belief System and Caregiving Practices.

Demographic, Regional, and State-Level Trends of Mortality in Patients With Aortic Stenosis in United States, 2008 to 2018. (2020)
Journal Article
Mamas. (2020). Demographic, Regional, and State-Level Trends of Mortality in Patients With Aortic Stenosis in United States, 2008 to 2018. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e017433 - ?. https://doi.org/10.1161/JAHA.120.017433

Background Aortic stenosis-related mortality might vary across demographic subsets, regions, and states in the United States. Methods and Results We reviewed the death certificate data from the Centers for Disease Control and Prevention Wide-Ranging... Read More about Demographic, Regional, and State-Level Trends of Mortality in Patients With Aortic Stenosis in United States, 2008 to 2018..

External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis (2020)
Journal Article
(2020). External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis. BMC Medicine, https://doi.org/10.1186/s12916-020-01766-9

BACKGROUND: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk during pregnancy is required to plan management. Although there are many published prediction models for pre-eclamps... Read More about External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis.

Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes (2020)
Journal Article
Mohamed, M., Rashid, M., Farooq, S., Siddiqui, N., Parwani, P., Shiers, D., …Mamas, M. (2020). Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes. European Heart Journal, 41(Supplement_2), https://doi.org/10.1093/ehjci/ehaa946.3146

Background
Severe mental illness (SMI) is associated with an increased risk of cardiovascular disease and mortality. However, it is unclear whether SMI patients are just as likely to receive guideline-recommended therapy for AMI as those without men... Read More about Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes.