All Outputs (90)

Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents (2020)
Thesis
Abdulrahman, M. F. A. (2020). Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents. (Thesis). Keele University

The rate-limiting step for oral absorption of hydrophobic drugs and solubility is the drug dissolution rate in the GI fluids. Several novel and traditional methods have been used to improve the solubility rates of poorly water soluble drugs. The prof... Read More about Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents.

Understanding gender and its relation to the philosophy of personal identity (2020)
Thesis
McCarthy, J. (2020). Understanding gender and its relation to the philosophy of personal identity. (Thesis). Keele University

The aim of this thesis is to establish that there is no metaphysical account of personal identity that requires us to regard gender as essential to our identities. I shall begin by examining forms of essentialism as well as rejections of essentialism... Read More about Understanding gender and its relation to the philosophy of personal identity.

The United Kingdom in the European Community: The diplomacy of the UK government towards the Single European Act, 1984-5 (2020)
Thesis
Bienek, C. J. (2020). The United Kingdom in the European Community: The diplomacy of the UK government towards the Single European Act, 1984-5. (Thesis). Keele University

This dissertation examines the policy making of the United Kingdom towards the Single European Act (SEA) from June 1984 to December 1985. The SEA codified the practice of foreign policy coordination and began a process of liberalising the Single Mark... Read More about The United Kingdom in the European Community: The diplomacy of the UK government towards the Single European Act, 1984-5.

Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin (2020)
Thesis
Earps, H. F. (2020). Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin. (Thesis). Keele University

Human immunoglobulin (Ig) G is the most commonly found class of antibody in the human body and is involved in pathogen recognition as a part of the adaptive and innate immune response. Recognition occurs through the fragment antibody binding (FAB) re... Read More about Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin.

Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways (2020)
Thesis
Šoltić, D. (2020). Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways. (Thesis). Keele University

Spinal muscular atrophy (SMA) is a debilitating genetic disorder, characterised by homozygous loss of the survival of motor neuron 1 (SMN1) gene, resulting in insufficient levels of ubiquitously expressed survival of motor neuron (SMN) protein. The t... Read More about Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways.

Self-management support for people with Multiple Sclerosis (2020)
Thesis
Al Abbad, B. K. N. (2020). Self-management support for people with Multiple Sclerosis. (Thesis). Keele University

Background
Self-management programmes help people with long term conditions, such as Multiple Sclerosis (MS), manage symptoms, and contain utilization of health-care resources. However, the optimum level and type of support for people with MS (PwMS... Read More about Self-management support for people with Multiple Sclerosis.

Enabling teachers to promote incremental theories of intelligence in young children: an intervention and an instrument (2020)
Thesis
Garnett, N. J. (2020). Enabling teachers to promote incremental theories of intelligence in young children: an intervention and an instrument. (Thesis). Keele University

The primary focus of this thesis was to translate the rich ‘implicit theories of intelligence’ framework into an accessible intervention to allow teachers to promote growth mindsets in their pupils. A growth mindset is an implicit belief that one can... Read More about Enabling teachers to promote incremental theories of intelligence in young children: an intervention and an instrument.

Mathematical modelling of cartilage and bone defect healing after cell implantation (2020)
Thesis
Campbell, K. (2020). Mathematical modelling of cartilage and bone defect healing after cell implantation. (Thesis). Keele University

This thesis is concerned with mathematically modelling the regeneration of cartilage and cartilage-bone defects. Defects of the bone-cartilage unit, namely chondral and osteochondral defects, are a leading cause of osteoarthritis, the most common typ... Read More about Mathematical modelling of cartilage and bone defect healing after cell implantation.

A critical race theory analysis of the reflections of Black West African adults on their education in English schools (2020)
Thesis
Tambi, T. M. (2020). A critical race theory analysis of the reflections of Black West African adults on their education in English schools. (Thesis). Keele University

Educational research relating to students of black and minority ethnic (BME) backgrounds in England often contains a disproportionately high coverage of issues of underachievement at the expense of the educational experiences of the students. Much of... Read More about A critical race theory analysis of the reflections of Black West African adults on their education in English schools.

Human cell therapies in preclinical and clinical studies of cartilage repair (2020)
Thesis
Perry, J. K. L. (2020). Human cell therapies in preclinical and clinical studies of cartilage repair. (Thesis). Keele University

Cell therapy offers potential to repair and regenerate damaged tissues. An established example of its use in the clinic is for treating cartilage defects. This thesis addresses this topic, both studying the use of imaging in such patients having had... Read More about Human cell therapies in preclinical and clinical studies of cartilage repair.

Bioimpedance as a predictor of survival in renal failure and associated comorbidities. (2020)
Thesis
Dudson, M. L. (2020). Bioimpedance as a predictor of survival in renal failure and associated comorbidities. (Thesis). Keele University

Background: Renal failure requiring dialysis is associated with a high mortality. One of the contributing causes is overhydration. Overhydration can be assessed by bioimpedance analysis (BIA)– the non-invasive electrical measure of small current thro... Read More about Bioimpedance as a predictor of survival in renal failure and associated comorbidities..

The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum (2020)
Thesis
Anagu, L. O. (2020). The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum. (Thesis). Keele University

Plasmodium falciparum encodes a family of key virulence genes called var genes. These encode adhesive proteins that are expressed on infected erythrocytes in a mutually exclusive manner. The parasite’s sirtuins have been implicated in epigenetic sele... Read More about The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum.

An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research (2020)
Thesis
Shenton, J. J. L. (2020). An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417292

Background
Research in the NHS is essential to provide evidence to improve services and patient outcomes. The Government’s continued commitment to research has been made clear through the inclusion of research in key NHS policy documents including t... Read More about An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research.

Hopf-Galois module structure of a class of tame quaternionic fields (2020)
Thesis
Taylor, S. J. (2020). Hopf-Galois module structure of a class of tame quaternionic fields. (Thesis). Keele University

We study the Hopf-Galois module structure of rings of integers in tame Galois extensions L=F of global fields with Galois group isomorphic to the quaternion group of order 8. We determine explicitly the Hopf algebras giving Hopf-Galois structures on... Read More about Hopf-Galois module structure of a class of tame quaternionic fields.

Confirmation of exoplanet candidates in the Wide-Angle Search for Planets survey via Doppler tomography (2020)
Thesis
Temple, L. Y. (2020). Confirmation of exoplanet candidates in the Wide-Angle Search for Planets survey via Doppler tomography. (Thesis). Keele University

This work reports the discovery of four new exoplanets, with host stars in the relatively sparse spectral type range mid-F–A. The planets were discovered using the transit method and confirmed via Doppler tomography. The first is WASP-167b/KELT-13b,... Read More about Confirmation of exoplanet candidates in the Wide-Angle Search for Planets survey via Doppler tomography.

Exploration of the use of decision analytic modelling in low back pain and sciatica (2020)
Thesis
Ashwell Hall, J. (2020). Exploration of the use of decision analytic modelling in low back pain and sciatica. (Thesis). Keele University

Low back pain (LBP) is a global public health problem. Keele University developed the STarT Back tool to stratify LBP patients according to their risk of persistent disability, matching treatments to individual risk. A 12-month trial-based economic e... Read More about Exploration of the use of decision analytic modelling in low back pain and sciatica.

Control and suppression of elastic waves using periodic metasurfaces and bridges (2020)
Thesis
Wootton, P. T. (2020). Control and suppression of elastic waves using periodic metasurfaces and bridges. (Thesis). Keele University

This thesis discusses how wave propagation in continuous linearly elastic media can be controlled or suppressed using periodic structures. This involves controlling 2D waves on a membrane, 3D longitudinal and transverse waves in a linearly elastic bu... Read More about Control and suppression of elastic waves using periodic metasurfaces and bridges.

Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates (2020)
Thesis
Dimitriou, E. (2020). Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates. (Thesis). Keele University

Alginate is an anionic polysaccharide comprised of β˗1,4˗linked D˗mannuronic acid (M) and L˗guluronic acid (G). The polymer is naturally harvested from seaweed and is widely exploited in various biotechnological and biomedical applications, due to th... Read More about Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates.

The effects of increased atmospheric reactive nitrogen deposition upon rates of biological nitrogen fixation in peatlands and temperate forests (2020)
Thesis
Saiz Val, E. (2020). The effects of increased atmospheric reactive nitrogen deposition upon rates of biological nitrogen fixation in peatlands and temperate forests. (Thesis). Keele University

Biological nitrogen fixation (BNF) is a microbial process that fixes atmospheric nitrogen (N2) gas into reactive, bioavailable forms (Nr). Naturally, lightning and BNF accounted for the entire Nr available for plant and microbial metabolic demands. H... Read More about The effects of increased atmospheric reactive nitrogen deposition upon rates of biological nitrogen fixation in peatlands and temperate forests.

Acute flares in knee osteoarthritis (2020)
Thesis
Parry, E. (2020). Acute flares in knee osteoarthritis. (Thesis). Keele University

Osteoarthritis affects 8.75 million people in the United Kingdom. Acute episodes of pain (“acute flares”) may be an important, although poorly understood, part of its natural history. This thesis is a mixed methods study of acute flares in knee osteo... Read More about Acute flares in knee osteoarthritis.