All Outputs (90)

The development of normative values of LCI in healthy school-children using the SF6 (Innocor) Multiple Breath Washout technique (2020)
Thesis
Alrumuh, A. K. (2020). The development of normative values of LCI in healthy school-children using the SF6 (Innocor) Multiple Breath Washout technique. (Thesis). Keele University

Background
Some respiratory diseases are believed to start early in life, yet manifest later as lung damage progresses. Early pathological changes are usually missed on traditional methods of lung function assessment. Therefore, multiple breath was... Read More about The development of normative values of LCI in healthy school-children using the SF6 (Innocor) Multiple Breath Washout technique.

Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model (2020)
Thesis
Whittle, E. L. (2020). Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model. (Thesis). Keele University

Asthma is one of the most common chronic diseases of the 21st century, affecting over 300 million people worldwide 1. It is an inflammatory disorder of the airways that is a major public concern globally due to increasing prevalence and rates of mort... Read More about Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model.

Exploring student victimisation and wellbeing in the UK higher education context (2020)
Thesis
Harrison, E. D. (2020). Exploring student victimisation and wellbeing in the UK higher education context. (Thesis). Keele University

Research into student bullying in Higher Education (HE) has been limited and most is based on childhood bullying research. Bullying in HE could disrupt student mental health and wellbeing at university - a topic that has recently gained traction. Add... Read More about Exploring student victimisation and wellbeing in the UK higher education context.

An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering (2020)
Thesis
Foster, N. C. (2020). An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering. (Thesis). Keele University

Articular cartilage is prone to degradation as a result of aging, disease and injury, which can lead to the onset of osteoarthritis (OA). The avascular nature of the tissue renders its endogenous repair capacity notoriously poor and its aneural natur... Read More about An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering.

From research to primary care: a knowledge mobilisation study in osteoarthritis (2020)
Thesis
Swaithes, L. R. (2020). From research to primary care: a knowledge mobilisation study in osteoarthritis. (Thesis). Keele University

Background
Osteoarthritis (OA) is the most common long-term condition in primary care and is one of the most frequent causes of pain, loss of function and disability. Research evidence alone does not always lead to changes in practice that benefit p... Read More about From research to primary care: a knowledge mobilisation study in osteoarthritis.

Agrippa's trilemma: scepticism and contemporary epistemology (2020)
Thesis
Burns, A. S. (2020). Agrippa's trilemma: scepticism and contemporary epistemology. (Thesis). Keele University

Take any belief of yours – even one about which you feel supremely confident. The Sceptic will ask: why do you think it is true? You might take yourself to have a very good reason to believe what you do. But the sceptic will also want to know why you... Read More about Agrippa's trilemma: scepticism and contemporary epistemology.

Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study (2020)
Thesis
Ismail, N. (2020). Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study. (Thesis). Keele University

The management of acute coronary syndrome (ACS) with antithrombotic medication achieves the desired goal of reducing the risk of future ischaemic events. However, these reductions are accompanied by increased risk of bleeding complications. A systema... Read More about Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study.

An investigation into the intricacies of the instructional model for early childhood education in rural Thai Child Development Centres (2020)
Thesis
Chongcharoen, D. (2020). An investigation into the intricacies of the instructional model for early childhood education in rural Thai Child Development Centres. (Thesis). Keele University

Thailand’s education system faces a problem with distinct disparities between levels of regional education management. Consequently, urban areas seem to have obvious perceivable advantages over rural area settings. In response to this problem, the ce... Read More about An investigation into the intricacies of the instructional model for early childhood education in rural Thai Child Development Centres.

Dynamic chirality and failure in structured materials with applications (2020)
Thesis
Garau, M. (2020). Dynamic chirality and failure in structured materials with applications. (Thesis). Keele University

We consider the vibration of two classes of discrete periodic systems and the resulting dynamic effects. We analyse elastic lattices connected to arrays of gyroscopic spinners, that confer chirality to the elastic system. It is shown in the time-harm... Read More about Dynamic chirality and failure in structured materials with applications.

Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells (2020)
Thesis
Grimes, D. (2020). Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells. (Thesis). Keele University

Pro-inflammatory cytokines and glucolipotoxicity are known mediators of beta cell death and dysfunction in the pathogenesis of type 1 and type 2 diabetes mellitus (DM). In contrast to the pro-apoptotic effects of long-chain saturated fatty acids in b... Read More about Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells.